2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. ATP disodium trihydrate

ATP disodium trihydrate  (Synonyms: Adenosine-5'-triphosphate disodium trihydrate)

Cat. No.: HY-B2176A Purity: 99.91%
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ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation.

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ATP disodium trihydrate Chemical Structure

ATP disodium trihydrate Chemical Structure

CAS No. : 51963-61-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 In-stock
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500 mg USD 96 In-stock
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Based on 73 publication(s) in Google Scholar

Other Forms of ATP disodium trihydrate:

ATP disodium trihydrate Related Antibodies

Top Publications Citing Use of Products

72 Publications Citing Use of MCE ATP disodium trihydrate

WB

    ATP disodium trihydrate purchased from MedChemExpress. Usage Cited in: Transl Res. 2022.

    LPS/ATP treatment significantly promotes expression of NLRP3 and production of N-GSDMD in HAEC. HAEC are pretreated with LPS (500ng/ml) for 5 h and then stimulated with ATP (5 mM) for 1 h.

    • Biological Activity

    • Purity & Documentation

    • References

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    Description

    ATP disodium trihydrate (Adenosine 5'-triphosphate disodium trihydrate) is a central component of energy storage and metabolism in vivo. ATP disodium trihydrate provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium trihydrate is an important endogenous signaling molecule in immunity and inflammation[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 EC50
    2 nM
    Compound: 13a
    Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)
    Agonists activity was evaluated by release of [Ca2+] release of HEK 293 cells stably transfected with rat-brain P2Y purinoceptor 1 (P2Y1-R)
    		[PMID: 12431066]
    In Vitro

    ATP disodium trihydrate (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
    ATP disodium trihydrate (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
    ATP disodium trihydrate promotes neutrophil chemotaxis in vitro[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ATP disodium trihydrate Related Antibodies
    In Vivo

    ATP disodium trihydrate (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
    ATP disodium trihydrate induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Four-week-old Kunming mice (18-22 g)[4]
    Dosage: 50 mg/kg
    Administration: Intraperitoneal injection, before bacterial (E. coli) challenge
    Result: Protected mice from bacterial infection.
    Molecular Weight

    605.19

    Formula

    C10H20N5Na2O16P3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=P(O[Na])(O[Na])OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1O)(O)=O)(O)=O.O.O.O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 175 mg/mL (289.17 mM; Need ultrasonic)

    DMSO : 1 mg/mL (1.65 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6524 mL 8.2619 mL 16.5237 mL
    5 mM 0.3305 mL 1.6524 mL 3.3047 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (82.62 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 1.6524 mL 8.2619 mL 16.5237 mL 41.3093 mL
    H2O 5 mM 0.3305 mL 1.6524 mL 3.3047 mL 8.2619 mL
    10 mM 0.1652 mL 0.8262 mL 1.6524 mL 4.1309 mL
    15 mM 0.1102 mL 0.5508 mL 1.1016 mL 2.7540 mL
    20 mM 0.0826 mL 0.4131 mL 0.8262 mL 2.0655 mL
    25 mM 0.0661 mL 0.3305 mL 0.6609 mL 1.6524 mL
    30 mM 0.0551 mL 0.2754 mL 0.5508 mL 1.3770 mL
    40 mM 0.0413 mL 0.2065 mL 0.4131 mL 1.0327 mL
    50 mM 0.0330 mL 0.1652 mL 0.3305 mL 0.8262 mL
    60 mM 0.0275 mL 0.1377 mL 0.2754 mL 0.6885 mL
    80 mM 0.0207 mL 0.1033 mL 0.2065 mL 0.5164 mL
    100 mM 0.0165 mL 0.0826 mL 0.1652 mL 0.4131 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    ATP disodium trihydrate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    ATP disodium51963-61-2Adenosine-5'-triphosphate disodiumEndogenous MetaboliteenergystoragemetabolismimmunityinflammationNLRP3inflammasomecytokineInhibitorinhibitorinhibit

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