2. Anti-infection Apoptosis PI3K/Akt/mTOR Immunology/Inflammation
  3. Bacterial Apoptosis Fungal PI3K Akt TNF Receptor Interleukin Related
  4. Beauvericin

Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages.

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Beauvericin Chemical Structure

Beauvericin Chemical Structure

CAS No. : 26048-05-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Beauvericin:

Beauvericin Related Antibodies

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Description

Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages[1][2][3][4][5][6][7][8][9].

IC50 & Target

ACAT

 

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
1 μM
Compound: 12
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
[PMID: 36288556]
Huh-7 IC50
4.3 μM
Compound: 12
Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
Antiproliferative activity against human Huh-7 cells assessed as reduction in cell viability after 48 hr by CCK-8 assay
[PMID: 36288556]
In Vitro

Beauvericin (0-20 μM; 12, 24 and 36 h) has a strong antiproliferative activity against H22 hepatoma cells and promotes apoptosis of H22 hepatoma cells[5].
Beauvericin (50 μM; 72 h) induces apoptosis in turkey peripheral mononuclear cells[6].
Beauvericin (0.3-100 µM) reversibly inhibits L-type voltage-dependent Ca2+ current (ICa,L) in NG108-15 neuronal cells in a concentration-dependent manner with an IC50 value of 4 µM[7].
Beauvericin has IC50 values ​​of 1.0 µM, 2.9 µM, and 2.5 µM for immature dendritic cells, mature dendritic cells, and macrophages, respectively[8].
Beauvericin (1.6 and 2.4 µM; 2 d) reduces CCR7 expression and increases IL-10 secretion in maturing dendritic cells[8].
Beauvericin is a potent inhibitor of CYP3A1/2 in rat liver microsomes (IC50=1.3 mM)[9].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Beauvericin Related Antibodies

Cell Viability Assay[5]

Cell Line: H22 liver cancer cells
Concentration: 0, 1, 3, 5,10,15 and 20 µM
Incubation Time: 12、24 and 36 h
Result: Inhibited the growth of H22 cells in a dose-dependent manner.

Western Blot Analysis[5]

Cell Line: H22 liver cancer cells
Concentration: 0, 1, 3, 5,10,15 and 20 µM
Incubation Time: 12、24 and 36 h
Result: Upregulated the Bax/Bcl-2 ratio and the levels of cleaved caspase-9 and cleaved caspase-3, and downregulated the p-PI3K/PI3K ratio and p-AKT/AKT ratio.
In Vivo

Beauvericin (5 mg/kg; i.p.; after the first dosing cycle, observe for two days and continue the second dosing cycle) reduces tumor volume and increases necrosis in allogeneic transplant model mice[3].
Beauvericin (3, 5, 7 mg/kg; i.p.; once a week for three weeks) can significantly inhibit the growth of H22 allogeneic transplant model mice and increase the levels of TNF-α and IL-2 in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice injected subcutaneously with mouse CT-26 colon cancer cells on the right side[3]
Dosage: 5 mg/kg
Administration: ntraperitoneal injection (i.p.)；The drug was administered on the third day after the injection of colon cancer cells and continued once a day for five days, then stopped for two days of observation, and continued on the tenth day after the injection of colon cancer cells, and continued once a day for four days.
Result: Reduced the average tumor volume by 52.8 % and the average tumor weight by 60 %.
Animal Model: Human cervical cancer KB-3-1 xenograft mouse model[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.)； The drug was administered once a day starting on the fifth day after cervical cancer injection for five days, followed by two days of observation. The drug was administered once a day starting on the twelfth day after cervical cancer cell injection for four days.
Result: Reduced the average tumor volume by 31.3 % and the average tumor weight by 31.2 %.
Molecular Weight

783.95

Formula

C45H57N3O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN([C@H](C(O[C@](C(N([C@H](C(O[C@@H]1C(C)C)=O)CC2=CC=CC=C2)C)=O)([H])C(C)C)=O)CC3=CC=CC=C3)C([C@H](OC([C@@H](N(C1=O)C)CC4=CC=CC=C4)=O)C(C)C)=O
Structure Classification
Initial Source

Fusarium proliferatum,F. semitectum, and F. subglutinans
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (127.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2756 mL 6.3780 mL 12.7559 mL
5 mM 0.2551 mL 1.2756 mL 2.5512 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.95%

SDS (393 KB)

COA (261 KB) HNMR (299 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2756 mL 6.3780 mL 12.7559 mL 31.8898 mL
5 mM 0.2551 mL 1.2756 mL 2.5512 mL 6.3780 mL
10 mM 0.1276 mL 0.6378 mL 1.2756 mL 3.1890 mL
15 mM 0.0850 mL 0.4252 mL 0.8504 mL 2.1260 mL
20 mM 0.0638 mL 0.3189 mL 0.6378 mL 1.5945 mL
25 mM 0.0510 mL 0.2551 mL 0.5102 mL 1.2756 mL
30 mM 0.0425 mL 0.2126 mL 0.4252 mL 1.0630 mL
40 mM 0.0319 mL 0.1594 mL 0.3189 mL 0.7972 mL
50 mM 0.0255 mL 0.1276 mL 0.2551 mL 0.6378 mL
60 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.5315 mL
80 mM 0.0159 mL 0.0797 mL 0.1594 mL 0.3986 mL
100 mM 0.0128 mL 0.0638 mL 0.1276 mL 0.3189 mL
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Beauvericin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Beauvericin26048-05-5BacterialApoptosisFungalPI3KAktTNF ReceptorInterleukin RelatedPhosphoinositide 3-kinasePKBProtein kinase BTumor Necrosis Factor ReceptorTNFRILInhibitorinhibitorinhibit

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