Chlorthalidone-d₄

Name: Chlorthalidone-d 4
Brand: MedChemExpress
SKU: HY-15833S
Rating: 4.5 (1 reviews)

Cat. No.: HY-15833S Purity: 97.50%: FAQs
Data Sheet SDS COA Handling Instructions

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Chlorthalidone-d₄ is the deuterium labeled Chlorthalidone. Chlorthalidone is a thiazide-like diuretic used to treat hypertension.

For research use only. We do not sell to patients.

Chlorthalidone-d<sub>4</sub> Chemical Structure

Chlorthalidone-d₄ Chemical Structure

CAS No. : 1794941-44-8

Size	Price	Stock	Quantity
1 mg	USD 610	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Chlorthalidone-d₄:

Chlorthalidone In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Chlorthalidone-d₄ is the deuterium labeled Chlorthalidone. Chlorthalidone is a thiazide-like diuretic used to treat hypertension.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

342.79

Formula

C₁₄H₇D₄ClN₂O₄S

CAS No.

1794941-44-8

Unlabeled CAS

77-36-1

Appearance

Solid

Color

White to off-white

SMILES

OC1(C2=CC(S(N)(=O)=O)=C(C=C2)Cl)C3=C([2H])C([2H])=C([2H])C([2H])=C3C(N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 41 mg/mL (119.61 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9172 mL	14.5862 mL	29.1724 mL
5 mM	0.5834 mL	2.9172 mL	5.8345 mL
10 mM	0.2917 mL	1.4586 mL	2.9172 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.49%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (256 KB) Elemental Analysis Report (114 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Barrios V, et al. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014 Jul 30;7:35-47.;Ettinger B, et al. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol. 1988 Apr;139(4):679-84. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9172 mL	14.5862 mL	29.1724 mL	72.9309 mL
	5 mM	0.5834 mL	2.9172 mL	5.8345 mL	14.5862 mL
	10 mM	0.2917 mL	1.4586 mL	2.9172 mL	7.2931 mL
	15 mM	0.1945 mL	0.9724 mL	1.9448 mL	4.8621 mL
	20 mM	0.1459 mL	0.7293 mL	1.4586 mL	3.6465 mL
	25 mM	0.1167 mL	0.5834 mL	1.1669 mL	2.9172 mL
	30 mM	0.0972 mL	0.4862 mL	0.9724 mL	2.4310 mL
	40 mM	0.0729 mL	0.3647 mL	0.7293 mL	1.8233 mL
	50 mM	0.0583 mL	0.2917 mL	0.5834 mL	1.4586 mL
	60 mM	0.0486 mL	0.2431 mL	0.4862 mL	1.2155 mL
	80 mM	0.0365 mL	0.1823 mL	0.3647 mL	0.9116 mL
	100 mM	0.0292 mL	0.1459 mL	0.2917 mL	0.7293 mL