2. Induced Disease Models Products Apoptosis Metabolic Enzyme/Protease
  3. Immunology and Inflammatory Disease Models Apoptosis Aldehyde Dehydrogenase (ALDH)
  4. Hapten
  5. Citral

Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects[2][3].

For research use only. We do not sell to patients.

Citral Chemical Structure

Citral Chemical Structure

CAS No. : 5392-40-5

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 38 In-stock
Solution
10 mM * 1 mL in DMSO USD 38 In-stock
Liquid
50 mg USD 35 In-stock
100 mg USD 55 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Citral:

Citral Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Citral

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects[2][3].
In Vitro

Citral (10, 50, 100 μg/mL, 72 h) has no cytotoxicity to J774 macrophages[1].
Citral (0-0.5 μM, 72 h) inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 breast cancer cell line[2].
Citral (0-100 μg/mL, 72 h) exhibits anti-proliferative and pro-apoptotic activities in MDA-MB-231 breast cancer cell line[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Citral Related Antibodies

Cell Viability Assay[1].

Cell Line: J774 cell
Concentration: 10, 50, 100 μg/mL
Incubation Time: 72 h
Result: Didn't affect the cell viability of J774 cells

Cell Proliferation Assay[2].

Cell Line: MCF-7 cell
Concentration: 0-0.5 μM
Incubation Time: 72 h
Result: Inhibited the proliferation of MCF-7 cells

Cell Cytotoxicity Assay[3].

Cell Line: MDA-MB-231 cell
Concentration: 0-100 μg/mL
Incubation Time: 72 h
Result: Inhibited the cell viability of MDA-MB-231 cells
In Vivo

Citral (100 mg/kg, p.o.) improves the anti-hyperalgesic and anti-inflammatory activities in pleurisy mice[1].
Citral (10, 20, 40 mg/kg, i.p.) prevents LPS induced mouse endometritis by activating the Nrf2 signaling pathway and inhibiting ferroptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: pleurisy adult (2 to 3 months old) male Swiss mice[1].
Dosage: 100mg / kg body weight
Administration: oral gavage (p.o.)
Result: Reduced white blood cell count and TNF-α expression level [1].
Animal Model: Female BALB/c mice[4].
Dosage: 10, 20, 40 mg/kg body weight
Administration: intraperitoneal injection (i.p.)
Result: Attenuated uterine pathological damage, infammation, and ferroptosis[4].
Molecular Weight

152.23

Formula

C10H16O
CAS No.
Appearance

Liquid (Density: 0.888 g/cm3)

Color

Colorless to light yellow

SMILES

C/C(C)=C\CC/C(C)=C/C=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (328.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1 mg/mL (6.57 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.5690 mL 32.8450 mL 65.6901 mL
5 mM 1.3138 mL 6.5690 mL 13.1380 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (16.42 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (16.42 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (328.45 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥97.0%

COA (241 KB) HNMR (125 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 6.5690 mL 32.8450 mL 65.6901 mL 164.2252 mL
5 mM 1.3138 mL 6.5690 mL 13.1380 mL 32.8450 mL
DMSO 10 mM 0.6569 mL 3.2845 mL 6.5690 mL 16.4225 mL
15 mM 0.4379 mL 2.1897 mL 4.3793 mL 10.9483 mL
20 mM 0.3285 mL 1.6423 mL 3.2845 mL 8.2113 mL
25 mM 0.2628 mL 1.3138 mL 2.6276 mL 6.5690 mL
30 mM 0.2190 mL 1.0948 mL 2.1897 mL 5.4742 mL
40 mM 0.1642 mL 0.8211 mL 1.6423 mL 4.1056 mL
50 mM 0.1314 mL 0.6569 mL 1.3138 mL 3.2845 mL
60 mM 0.1095 mL 0.5474 mL 1.0948 mL 2.7371 mL
80 mM 0.0821 mL 0.4106 mL 0.8211 mL 2.0528 mL
100 mM 0.0657 mL 0.3285 mL 0.6569 mL 1.6423 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Citral Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Citral5392-40-5ApoptosisAldehyde Dehydrogenase (ALDH)analgesicanti-inflammatoryMCF-7 cellMDA-MB-231 cellInhibitorinhibitorinhibit

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