Cucumarioside A2-2

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Cucumarioside A2-2 is a triterpene glycoside with antitumor activity. Cucumarioside A2-2 can induce mouse macrophage polarization toward the M1 phenotype. Cucumarioside A2-2 pretreated macrophages can effectively and selectively target and kill multiple types of cancer cells. Cucumarioside A2-2-induced M1 macrophages can effectively target and penetrate tumor tissues and improve the survival rate of mice in an allogeneic model. Exogenous activation of Cucumarioside A2-2 provides a useful model for the subsequent development of antitumor cell immunosuppression.

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Cucumarioside A2-2 Chemical Structure

CAS No. : 95499-80-2

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Description	Cucumarioside A2-2 is a triterpene glycoside with antitumor activity. Cucumarioside A2-2 can induce mouse macrophage polarization toward the M1 phenotype. Cucumarioside A2-2 pretreated macrophages can effectively and selectively target and kill multiple types of cancer cells. Cucumarioside A2-2-induced M1 macrophages can effectively target and penetrate tumor tissues and improve the survival rate of mice in an allogeneic model. Exogenous activation of Cucumarioside A2-2 provides a useful model for the subsequent development of antitumor cell immunosuppression^[1].
Molecular Weight	1319.39
Formula	C₅₉H₉₁NaO₂₉S
CAS No.	95499-80-2
SMILES	C[C@@]12[C@@]3([C@@]([H])([C@@](OC3=O)(CCCC(C)=C)C)C(C2)=O)CC[C@]4(C1=CC[C@@]5([C@]4(C)CC[C@H](O[C@@H]6OC[C@H]([C@@H]([C@H]6O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O[C@@H]8OC[C@H]([C@@H]([C@H]8O)O)O)O)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)OC)O)CO)O)CO)C)O)OS(=O)(O[Na])=O)C5(C)C)[H])[H]
Structure Classification	Terpenoids Triterpenes
Initial Source	Animals Cucumaria japonica
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Holothurian triterpene glycoside cucumarioside A2-2 induces macrophages activation and polarization in cancer immunotherapy [Content Brief]