Cyanopindolol

Cat. No.: HY-W795507 Purity: 98.67%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (K_i: 2.1 and 3 nM respectively).

For research use only. We do not sell to patients.

Cyanopindolol Chemical Structure

CAS No. : 69906-85-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Cyanopindolol:

Cyanopindolol fumarate Get quote

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View All Adrenergic Receptor Isoform Specific Products:

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[3]

β3 adrenoceptor

5-HT_1A Receptor

2.1 nM (Ki)

5-HT_1B Receptor

3 nM (Ki)

Molecular Weight

287.36

Formula

C₁₆H₂₁N₃O₂

CAS No.

69906-85-0

Appearance

Solid

Color

White to off-white

SMILES

CC(C)(NCC(O)COC1=CC=CC2=C1C=C(C#N)N2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (348.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4800 mL	17.3998 mL	34.7996 mL
5 mM	0.6960 mL	3.4800 mL	6.9599 mL
10 mM	0.3480 mL	1.7400 mL	3.4800 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (17.40 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.67%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (251 KB) HNMR (141 KB) RP-HPLC (171 KB) LCMS (109 KB)

Handling Instructions (2659 KB)

References

[1]. Hoey A, et al. Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br J Pharmacol. 1996 Feb;117(4):712-6. [Content Brief]

[2]. Schlicker E, et al. Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Naunyn Schmiedebergs Arch Pharmacol. 1985 Dec;331(4):398-401. [Content Brief]

[3]. Langlois M, et al. Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors. Eur J Pharmacol. 1993 Jan 4;244(1):77-87. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4800 mL	17.3998 mL	34.7996 mL	86.9989 mL
	5 mM	0.6960 mL	3.4800 mL	6.9599 mL	17.3998 mL
	10 mM	0.3480 mL	1.7400 mL	3.4800 mL	8.6999 mL
	15 mM	0.2320 mL	1.1600 mL	2.3200 mL	5.7999 mL
	20 mM	0.1740 mL	0.8700 mL	1.7400 mL	4.3499 mL
	25 mM	0.1392 mL	0.6960 mL	1.3920 mL	3.4800 mL
	30 mM	0.1160 mL	0.5800 mL	1.1600 mL	2.9000 mL
	40 mM	0.0870 mL	0.4350 mL	0.8700 mL	2.1750 mL
	50 mM	0.0696 mL	0.3480 mL	0.6960 mL	1.7400 mL
	60 mM	0.0580 mL	0.2900 mL	0.5800 mL	1.4500 mL
	80 mM	0.0435 mL	0.2175 mL	0.4350 mL	1.0875 mL
	100 mM	0.0348 mL	0.1740 mL	0.3480 mL	0.8700 mL

Cyanopindolol Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyanopindolol69906-85-0Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorserotoninAdrenergic receptorInhibitorinhibitorinhibit

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