2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor 5-HT Receptor
  4. Cyanopindolol

Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (Ki: 2.1 and 3 nM respectively).

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Cyanopindolol Chemical Structure

Cyanopindolol Chemical Structure

CAS No. : 69906-85-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO USD 715 In-stock
Solid
5 mg USD 650 In-stock
10 mg USD 1050 In-stock
25 mg USD 2200 In-stock
50 mg USD 3500 In-stock
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Description

Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and 5-HT1B receptor (Ki: 2.1 and 3 nM respectively)[1][2][3].

IC50 & Target[3]

β3 adrenoceptor

 

5-HT1A Receptor

2.1 nM (Ki)

5-HT1B Receptor

3 nM (Ki)

Molecular Weight

287.36

Formula

C16H21N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(NCC(O)COC1=CC=CC2=C1C=C(C#N)N2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (348.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4800 mL 17.3998 mL 34.7996 mL
5 mM 0.6960 mL 3.4800 mL 6.9599 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (17.40 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4800 mL 17.3998 mL 34.7996 mL 86.9989 mL
5 mM 0.6960 mL 3.4800 mL 6.9599 mL 17.3998 mL
10 mM 0.3480 mL 1.7400 mL 3.4800 mL 8.6999 mL
15 mM 0.2320 mL 1.1600 mL 2.3200 mL 5.7999 mL
20 mM 0.1740 mL 0.8700 mL 1.7400 mL 4.3499 mL
25 mM 0.1392 mL 0.6960 mL 1.3920 mL 3.4800 mL
30 mM 0.1160 mL 0.5800 mL 1.1600 mL 2.9000 mL
40 mM 0.0870 mL 0.4350 mL 0.8700 mL 2.1750 mL
50 mM 0.0696 mL 0.3480 mL 0.6960 mL 1.7400 mL
60 mM 0.0580 mL 0.2900 mL 0.5800 mL 1.4500 mL
80 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0875 mL
100 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8700 mL
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Cyanopindolol Related Classifications

Keywords:

Cyanopindolol69906-85-0Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorserotoninAdrenergic receptorInhibitorinhibitorinhibit

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