2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Darotropium bromide

Darotropium bromide (GSK233705), a long-acting muscarinic antagonist and an inhaled anticholinergic, can be used for the research of chronic obstructive pulmonary disease (COPD).

For research use only. We do not sell to patients.

Darotropium bromide Chemical Structure

Darotropium bromide Chemical Structure

CAS No. : 850607-58-8

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Based on 1 publication(s) in Google Scholar

Darotropium bromide Related Antibodies

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Description

Darotropium bromide (GSK233705), a long-acting muscarinic antagonist and an inhaled anticholinergic, can be used for the research of chronic obstructive pulmonary disease (COPD)[1][2].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
< 10 nM
Compound: 34
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
Antagonist activity against human M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
[PMID: 19630384]
CHO IC50
< 10 nM
Compound: 4a
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
Antagonist activity against human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
[PMID: 19616944]
CHO IC50
< 10 nM
Compound: 4a
Antagonist activity against human cloned muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
Antagonist activity against human cloned muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
[PMID: 19616944]
CHO IC50
< 10 nM
Compound: 4a
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
Antagonist activity against human cloned muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR
[PMID: 19616944]
Molecular Weight

425.40

Formula

C24H29BrN2
CAS No.
SMILES

[H][C@]1(CC(C2=CC=CC=C2)(C#N)C3=CC=CC=C3)C[C@]4([H])[N+](C)(C)[C@@]([H])(CC4)C1.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Darotropium bromide Related Classifications

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× = ×
C1   V1   C2   V2

Keywords:

Darotropium850607-58-8GSK233705GSK 233705GSK-233705mAChRMuscarinic acetylcholine receptormuscarinicCOPDchronic obstructive pulmonary diseaseanticholinergicInhibitorinhibitorinhibit

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HY-14786
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