2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Eicosanedioic acid

Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

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Eicosanedioic acid Chemical Structure

Eicosanedioic acid Chemical Structure

CAS No. : 2424-92-2

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Based on 1 publication(s) in Google Scholar

Eicosanedioic acid Related Antibodies

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Description

Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eicosanedioic acid Related Antibodies
Molecular Weight

342.51

Formula

C20H38O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCCCCCCCCCCCCCCCCC(O)=O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (72.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9196 mL 14.5981 mL 29.1962 mL
5 mM 0.5839 mL 2.9196 mL 5.8392 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9196 mL 14.5981 mL 29.1962 mL 72.9906 mL
5 mM 0.5839 mL 2.9196 mL 5.8392 mL 14.5981 mL
10 mM 0.2920 mL 1.4598 mL 2.9196 mL 7.2991 mL
15 mM 0.1946 mL 0.9732 mL 1.9464 mL 4.8660 mL
20 mM 0.1460 mL 0.7299 mL 1.4598 mL 3.6495 mL
25 mM 0.1168 mL 0.5839 mL 1.1678 mL 2.9196 mL
30 mM 0.0973 mL 0.4866 mL 0.9732 mL 2.4330 mL
40 mM 0.0730 mL 0.3650 mL 0.7299 mL 1.8248 mL
50 mM 0.0584 mL 0.2920 mL 0.5839 mL 1.4598 mL
60 mM 0.0487 mL 0.2433 mL 0.4866 mL 1.2165 mL
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Eicosanedioic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eicosanedioic acid2424-92-2ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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