2. Gene
  3. RBM5 - RNA binding motif protein 5 Gene

RBM5 - RNA binding motif protein 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as G15; H37; RMB5; LUCA15; LUCA-15

Gene ID: 10181 | Gene type: protein coding

About RBM5

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,088,919-50,119,021 (from NCBI)

This gene has 26 transcripts (splice variants), 262 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 32.9), endometrium (RPKM 30.9) and 25 other tissues.

Summary

This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and Apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung Cancer. [provided by RefSeq, Oct 2011]

RBM5 Products(1)

mRNA Protein Name
NM_005778.4 NP_005769.1 RNA-binding protein 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables mRNA binding IDA
IDA: Inferred from direct assay
18840686 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18951082 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
18840686 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
18840686 GOA
involved in spliceosomal complex assembly IDA
IDA: Inferred from direct assay
18951082 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
18951082 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM5 Protein Structure

(100 - 171)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (181 - 209)

(233 - 308)

G-patch

G-patch: G-patch domain (743 - 787)

  • 0
  • 200
  • 400
  • 600
  • 815 a.a.
Protein Preferred Names Protein Names

RNA-binding protein 5

putative tumor suppressor LUCA15

RBM5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RBM5 P52756 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra RBM5 P52756 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra RBM5 P52756 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra RBM5 P52756 APOE Homo sapiens P02649
Validated Y2H
32814053
Intra RBM5 P52756 APOE Homo sapiens P02649
Y2H Array
32814053
Intra RBM5 P52756 APOE Homo sapiens P02649
Y2H Pooling
32814053
Intra RBM5 P52756 DHX15 Homo sapiens O43143
Pull Down
22569250
Intra RBM5 P52756 DHX15 Homo sapiens O43143
Anti Tag CoIP
22569250
Intra RBM5 P52756 DHX15 Homo sapiens O43143
Anti Bait CoIP
22569250
Intra RBM5 P52756 MLYCD Homo sapiens O95822-2
Y2H Array
32296183
Intra RBM5 P52756 MLYCD Homo sapiens O95822-2
Y2H Prey Pooling
32296183
Intra RBM5 P52756 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
26871637
Intra RBM5 P52756 MEOX2 Homo sapiens Q6FHY5
Y2H Array
26871637
Intra RBM5 P52756 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
26871637
Intra RBM5 P52756 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra RBM5 P52756 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra RBM5 P52756 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra RBM5 P52756 MEOX1 Homo sapiens P50221
Validated Y2H
26871637
Intra RBM5 P52756 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
26871637
Intra RBM5 P52756 MEOX1 Homo sapiens P50221
Y2H Array
26871637
Intra RBM5 P52756 MEOX1 Homo sapiens P50221
BiFC
26871637
Intra RBM5 P52756 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra RBM5 P52756 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra RBM5 P52756 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Anti Bait CoIP
22569250
Intra RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Anti Tag CoIP
22569250
Intra RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Y2H
22365833
Intra RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Pull Down
22569250
Intra RBM5 P52756 PRPF19 Homo sapiens Q9UMS4
Anti Tag CoIP
22365833
Intra RBM5 P52756 U2AF2 Homo sapiens P26368
Anti Bait CoIP
22569250
Intra RBM5 P52756 U2AF2 Homo sapiens P26368
Pull Down
22569250
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Primary Ovarian Insufficiency 6
Tarp Syndrome

TARPS

Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot

Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome

Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome

Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome

Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava

Pierre Robin Sequence - Congenital Heart Defect - Talipes

Pierre Robin Syndrome - Congenital Heart Defect - Talipes

Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava

Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Medulloblastoma Wnt Activated
Medulloblastoma Shh Activated
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11756 RBM5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RBM5 MGD MGI:1933204
Canis familiaris RBM5 VGNC VGNC:45424
Felis catus RBM5 VGNC VGNC:69265
Bos taurus RBM5 VGNC VGNC:33806
Macaca mulatta RBM5 VGNC VGNC:76682
Rattus norvegicus RBM5 RGD RGD:1305059