DHX15 - DEAH-box helicase 15 Gene

Homo sapiens

Also known as DBP1; DDX15; PRP43; PRPF43; hPrp43; PrPp43p

Gene ID: 1665 | Gene type: protein coding

About DHX15

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:24,527,475-24,584,554 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 18 paralogues. Ubiquitous expression in bone marrow (RPKM 42.0), lymph node (RPKM 36.6) and 25 other tissues.

Summary

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

DHX15 Products(1)

mRNA	Protein	Name
NM_001358.3	NP_001349.2	ATP-dependent RNA helicase DHX15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	32179686	GOA
enables RNA helicase activity	IDA IDA: Inferred from direct assay	32179686	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17332742	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	24990078	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	24990078	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	24990078	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type post-mRNA release spliceosomal complex	IDA IDA: Inferred from direct assay	19103666	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX15 Protein Structure

DEAD

Helicase_C

HA2

OB_NTP_bind

0
200
400
600
795 a.a.

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DHX15

ATP-dependent RNA helicase #46

DHX15 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DHX15	O43143	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	25416956
Intra	DHX15	O43143	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	25416956
Intra	DHX15	O43143	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	32296183
Intra	DHX15	O43143	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	32296183
Intra	DHX15	O43143	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	25416956
Intra	DHX15	O43143	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	32296183
Intra	DHX15	O43143	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	DHX15	O43143	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	DHX15	O43143	FXR1	Homo sapiens	P51114-2	Validated Y2H	32296183
Intra	DHX15	O43143	CAMSAP3	Homo sapiens	Q9P1Y5-2	Validated Y2H	32296183
Intra	DHX15	O43143	CAMSAP3	Homo sapiens	Q9P1Y5-2	Y2H Prey Pooling	32296183
Intra	DHX15	O43143	CAMSAP3	Homo sapiens	Q9P1Y5-2	Y2H Array	32296183
Intra	DHX15	O43143	NUDCD1	Homo sapiens	Q96RS6-1	Anti Tag CoIP	29021621
Intra	DHX15	O43143	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	24304693
Intra	DHX15	O43143	SUGP1	Homo sapiens	Q8IWZ8	Y2H	22365833
Intra	DHX15	O43143	KRT75	Homo sapiens	O95678	Validated Y2H	32296183
Intra	DHX15	O43143	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	DHX15	O43143	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	DHX15	O43143	ZGPAT	Homo sapiens	Q8N5A5	Y2H Prey Pooling	25416956
Intra	DHX15	O43143	ZGPAT	Homo sapiens	Q8N5A5	Y2H Array	25416956
Intra	DHX15	O43143	RBM5	Homo sapiens	P52756	Y2H	22569250
Intra	DHX15	O43143	RBM5	Homo sapiens	P52756	Anti Tag CoIP	22569250
Intra	DHX15	O43143	RBM5	Homo sapiens	P52756	Y2H	22365833
Intra	DHX15	O43143	RBM5	Homo sapiens	P52756	Anti Tag CoIP	22365833
Intra	DHX15	O43143	RBM5	Homo sapiens	P52756	Anti Tag CoIP	24304693
Intra	DHX15	O43143	RBM10	Homo sapiens	P98175	Anti Tag CoIP	29021621
Intra	DHX15	O43143	RBM17	Homo sapiens	Q96I25	Y2H Array	32296183
Intra	DHX15	O43143	RBM17	Homo sapiens	Q96I25	Anti Tag CoIP	22365833
Intra	DHX15	O43143	RBM17	Homo sapiens	Q96I25	Anti Tag CoIP	29021621
Intra	DHX15	O43143	RBM17	Homo sapiens	Q96I25	Y2H Prey Pooling	32296183
Intra	DHX15	O43143	RBM17	Homo sapiens	Q96I25	Y2H	22365833
Intra	DHX15	O43143	RBM17	Homo sapiens	Q96I25	Y2H Prey Pooling	25416956
Intra	DHX15	O43143	RBM17	Homo sapiens	Q96I25	Validated Y2H	32296183
Intra	DHX15	O43143	AGGF1	Homo sapiens	Q8N302	Y2H Array	32296183
Intra	DHX15	O43143	AGGF1	Homo sapiens	Q8N302	Validated Y2H	32296183
Intra	DHX15	O43143	AGGF1	Homo sapiens	Q8N302	Y2H Prey Pooling	32296183
Intra	DHX15	O43143	GPANK1	Homo sapiens	O95872	Validated Y2H	32296183
Intra	DHX15	O43143	NKRF	Homo sapiens	O15226	Anti Tag CoIP	29021621

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

X-Linked Intellectual Disability-Short Stature-Overweight Syndrome

Mrx12	Mrx35
X-Linked Mental Retardation 12	X-Linked Mental Retardation 35

Posterior Cerebral Artery Infarction

Infarction, Posterior Cerebral Artery

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03748	DHX15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DHX15	RGD	RGD:1308072
Mus musculus	DHX15	MGD	MGI:1099786
Felis catus	DHX15	VGNC	VGNC:61474
Canis familiaris	DHX15	VGNC	VGNC:39939
Bos taurus	DHX15	VGNC	VGNC:28048
Macaca mulatta	DHX15	VGNC	VGNC:71760

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