2. Gene
  3. FKBP8 - FKBP prolyl isomerase 8 Gene

FKBP8 - FKBP prolyl isomerase 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FKBP38; FKBPr38

Gene ID: 23770 | Gene type: protein coding

About FKBP8

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,531,763-18,543,573 (from NCBI)

This gene has 14 transcripts (splice variants), 207 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 106.8), brain (RPKM 101.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the Other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

FKBP8 Products(2)

mRNA Protein Name
NM_001308373.2 NP_001295302.1 peptidyl-prolyl cis-trans isomerase FKBP8 isoform 2
NM_012181.5 NP_036313.3 peptidyl-prolyl cis-trans isomerase FKBP8 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calmodulin binding EXP
EXP: Inferred from Experiment
20707607 GOA
enables calmodulin binding IPI
IPI: Inferred from physical interaction
24145868 GOA
enables disordered domain specific binding IPI
IPI: Inferred from physical interaction
15733859 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
17024179 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16844119 GOA
enables protein folding chaperone IMP
IMP: Inferred from mutant phenotype
29916806 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15733859 GOA
acts upstream of or within protein folding IMP
IMP: Inferred from mutant phenotype
29916806 GOA
involved in protein localization to mitochondrion IPI
IPI: Inferred from physical interaction
31908024 GOA
involved in regulation of mitophagy IDA
IDA: Inferred from direct assay
28381481 GOA
Cellular Component GO Annotation Evidence Reference Source
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
15733859 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FKBP8 Protein Structure

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (116 - 200)

TPR_16

TPR_16: Tetratricopeptide repeat (278 - 339)

  • 0
  • 100
  • 200
  • 300
  • 412 a.a.
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP8

38 kDa FK506-binding protein

FKBP8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FKBP8 Q14318 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
FKBP8 Q14318 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
FKBP8 Q14318 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
FKBP8 Q14318 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
FKBP8 Q14318 TMX1 Homo sapiens Q9H3N1
Validated Y2H
32296183
Intra
FKBP8 Q14318 TMX1 Homo sapiens Q9H3N1
Y2H Array
32296183
Intra
FKBP8 Q14318 TMX1 Homo sapiens Q9H3N1
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
FKBP8 Q14318 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
FKBP8 Q14318 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
FKBP8 Q14318 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
FKBP8 Q14318 EGLN1 Homo sapiens Q9GZT9
Anti Tag CoIP
17353276
Intra
FKBP8 Q14318 EGLN1 Homo sapiens Q9GZT9
Gal4 VP16 Complement
17353276
Intra
FKBP8 Q14318 EGLN1 Homo sapiens Q9GZT9
Y2H
17353276
Intra
FKBP8 Q14318 EGLN1 Homo sapiens Q9GZT9
Pull Down
17353276
Intra
FKBP8 Q14318 EGLN1 Homo sapiens Q9GZT9
Confocal
17353276
Intra
FKBP8 Q14318 TMEM254 Homo sapiens Q8TBM7
Validated Y2H
32296183
Intra
FKBP8 Q14318 SLC35B1 Homo sapiens P78383
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 SLC35B1 Homo sapiens P78383
Y2H Array
32296183
Cross
FKBP8 Q14318 PB1 Influenza A virus C5E526
Anti Tag CoIP
28169297
Intra
FKBP8 Q14318 FGF14 Homo sapiens Q92915-2
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 FGF14 Homo sapiens Q92915-2
Y2H Array
32296183
Intra
FKBP8 Q14318 FGF14 Homo sapiens Q92915-2
Validated Y2H
32296183
Intra
FKBP8 Q14318 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
FKBP8 Q14318 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
FKBP8 Q14318 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra
FKBP8 Q14318 RHBDD2 Homo sapiens Q6NTF9-3
Validated Y2H
32296183
Intra
FKBP8 Q14318 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
FKBP8 Q14318 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
FKBP8 Q14318 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra
FKBP8 Q14318 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
FKBP8 Q14318 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
Intra
FKBP8 Q14318 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra
FKBP8 Q14318 SLC35A5 Homo sapiens Q9BS91
Y2H Array
32296183
Intra
FKBP8 Q14318 SLC35A5 Homo sapiens Q9BS91
Validated Y2H
32296183
Intra
FKBP8 Q14318 SLC35A5 Homo sapiens Q9BS91
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 CXCR2 Homo sapiens P25025
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 CXCR2 Homo sapiens P25025
Y2H Array
32296183
Intra
FKBP8 Q14318 HSP90AA1 Homo sapiens P07900
Anti Tag CoIP
17024179
Intra
FKBP8 Q14318 HSP90AA1 Homo sapiens P07900
Anti Tag CoIP
35271311
Intra
FKBP8 Q14318 EGFR Homo sapiens P00533
Ub Reconstruction
20029029
Intra
FKBP8 Q14318 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
35271311
Intra
FKBP8 Q14318 MFSD14B Homo sapiens Q5SR56
Validated Y2H
32296183
Intra
FKBP8 Q14318 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
FKBP8 Q14318 ZFYVE27 Homo sapiens Q5T4F4
Y2H
17082457
Intra
FKBP8 Q14318 ZFYVE27 Homo sapiens Q5T4F4
Y2H
18459960
Intra
FKBP8 Q14318 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
FKBP8 Q14318 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
FKBP8 Q14318 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra
FKBP8 Q14318 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra
FKBP8 Q14318 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
FKBP8 Q14318 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 NS5A Hepacivirus hominis O39474
Y2H
17024179
Intra
FKBP8 Q14318 NS5A Hepacivirus hominis O39474
Anti Tag CoIP
16844119
Intra
FKBP8 Q14318 NS5A Hepacivirus hominis O39474
Imaging
16844119
Intra
FKBP8 Q14318 NS5A Hepacivirus hominis O39474
Anti Bait CoIP
16844119
Intra
FKBP8 Q14318 NS5A Hepacivirus hominis O39474
Anti Tag CoIP
17024179
Intra
FKBP8 Q14318 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
FKBP8 Q14318 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
FKBP8 Q14318 TMEM43 Homo sapiens Q9BTV4
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 TMEM43 Homo sapiens Q9BTV4
Y2H Array
32296183
Intra
FKBP8 Q14318 TMEM43 Homo sapiens Q9BTV4
Validated Y2H
32296183
Intra
FKBP8 Q14318 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
FKBP8 Q14318 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
FKBP8 Q14318 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
FKBP8 Q14318 CYBRD1 Homo sapiens Q53TN4
Validated Y2H
32296183
Intra
FKBP8 Q14318 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra
FKBP8 Q14318 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
FKBP8 Q14318 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
FKBP8 Q14318 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra
FKBP8 Q14318 CYB561 Homo sapiens P49447
Y2H Array
32296183
Cross
FKBP8 Q14318 PB1 Influenza A virus Q5EP37
Anti Tag CoIP
28169297
Cross
FKBP8 Q14318 PB1 Influenza A virus P03431
Anti Tag CoIP
28169297
Cross
FKBP8 Q14318 PB1 Influenza A virus Q1K9H5
Anti Tag CoIP
28169297
Intra
FKBP8 Q14318 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
SPR
18216108
Intra
FKBP8 Q14318 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Anti Tag CoIP
18216108
Intra
FKBP8 Q14318 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
IF
18216108
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos
Pineal Region Germinoma

Pineal Germinoma
Long Qt Syndrome 2

LQT2

Long Qt Syndrome, Acquired, Reduced Susceptibility To

Long Qt Syndrome 1/2

Long Qt Syndrome 2/3

Long Qt Syndrome 2/5

Long Qt Syndrome 2, Acquired, Susceptibility To

Long Qt Syndrome, Acquired, Reduced

Long Qt Syndrome Type 2

Long Qt Syndrome 2/9

Lqt1/2

Lqt2/3

Lqt2/5

Lqt2/9

Susceptibility To Acquired Long Qt Syndrome 2

Long Qt Syndrome-2

Qt Syndrome, Long, Type 2

Long Qt Syndrome 1-2

Long Qt Syndrome 2-3

Long Qt Syndrome 2-5

Long Qt Syndrome 9
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04968 FKBP8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FKBP8 VGNC VGNC:103818
Rattus norvegicus FKBP8 RGD RGD:1308670
Felis catus FKBP8 VGNC VGNC:62284
Mus musculus FKBP8 MGD MGI:1341070
Canis familiaris FKBP8 VGNC VGNC:40894