CDK8 - cyclin dependent kinase 8 Gene

Homo sapiens

Also known as K35; IDDHBA

Gene ID: 1024 | Gene type: protein coding

About CDK8

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:26,254,129-26,405,238 (from NCBI)

This gene has 11 transcripts (splice variants), 217 orthologues, 26 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 6.1), duodenum (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

CDK8 Products(5)

mRNA	Protein	Name
NM_001318368.2	NP_001305297.1	cyclin-dependent kinase 8 isoform 2
NM_001346501.2	NP_001333430.1	cyclin-dependent kinase 8 isoform 3
XM_047430033.1	XP_047285989.1	cyclin-dependent kinase 8 isoform X1
XM_011534865.3	XP_011533167.1	cyclin-dependent kinase 8 isoform X2
NM_001260.3	NP_001251.1	cyclin-dependent kinase 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7568034	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	30905399	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15009212	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CKM complex	IPI IPI: Inferred from physical interaction	19047373	GOA
part of cyclin-dependent protein kinase holoenzyme complex	IDA IDA: Inferred from direct assay	21806996	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	14638676	GOA
part of mediator complex	IMP IMP: Inferred from mutant phenotype	30905399	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	22869755	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16109376	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22869755	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK8 Protein Structure

Pkinase

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 8

CDK8 protein kinase	cell division protein kinase 8
mediator complex subunit CDK8	mediator of RNA polymerase II transcription subunit CDK8
protein kinase K35

Related Diseases

Diseases

Alias

Med23

Intellectual Disability, Autosomal Recessive 18

Autosomal Recessive Nonsyndromic Mental Retardation-18

Thoracic Benign Neoplasm

Benign Neoplasm Of Thorax

Ebstein Anomaly

Ebstein'S Anomaly	Ebstein'S Anomaly Of Common Atrioventricular Valve
Ebstein'S Anomaly Of Right Atrioventricular Valve	Ebstein'S Anomaly Of Tricuspid Valve
Ebstein'S Malformation	Ebstein Malformation Of The Tricuspid Valve
Ebstein Anomaly Of The Tricuspid Valve	Ebstein Disease
Accessory Tricuspid Valve Tissue	Congenital Ebstein Deformity Of Tricuspid Valve
Ebstein Syndrome	Ebstein Cardiopathy
Ebstein Anomaly Of Tricuspid Valve

Opitz-Kaveggia Syndrome

Fg Syndrome	Fgs1
Fgs	Keller Syndrome
OKS	Fg Syndrome 1
Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum	Fg Syndrome Type 1
Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Blepharophimosis Mental Retardation Syndromes
Sbbys Syndrome	Say Barber Biesecker Young-Simpson Syndrome
Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type	Bmrs, Ohdo Type
Blepharophimosis Syndrome, Ohdo Type	Ohdo-Madokoro-Sonoda Syndrome
Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type	Blepharophimosis - Intellectual Disability Syndrome

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Congenital Anomaly Of Heart
Heart Defect	Heart Malformation
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Uterine Benign Neoplasm

Developmental And Epileptic Encephalopathy 87

DEE87	Epileptic Encephalopathy, Early Infantile, 87
Eiee87	Developmental And Epileptic Encephalopathy, 87
Early Infantile Epileptic Encephalopathy 87

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities

IDDHBA

Heart, Malformation Of

Hydrocephalus, Congenital, 1

Hydrocephaly	Ventriculomegaly
Hydrocephalus, Nonsyndromic, Autosomal Recessive 1	HYC1
Congenital Non-Communicating Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive 1, Formerly
Congenital Obstructive Hydrocephalus	Hydrocephalus, Non-Syndromic, Autosomal Recessive 1
Hydrocephalus

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia	Diaphragmatic Hernia
Hernia, Congenital Diaphragmatic 1	Cdh
Congenital Diaphragmatic Defect	Hernia, Diaphragmatic
Dih	Hernia, Congenital Diaphragmatic
Hcd	Diaphragmatic Defect, Congenital
Diaphragm, Unilateral Agenesis Of	Hemidiaphragm, Agenesis Of
Agenesis Of Hemidiaphragm	Unilateral Agenesis Of Diaphragm
Hernia Diaphragmatic	Hernia Diaphragmatic Congenital
Hiatus Hernia	Oesophageal Hiatus Hernia
Paraoesophageal Hernia	Sliding Hiatus Hernia
Congenital Diaphragm Hernia	Congenital Diaphragm Defect With Hernia
Gross Congenital Diaphragm Defect

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Breast Benign Neoplasm

Benign Tumour Of Breast

Benign Neoplasm Of Female Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (33)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0400	Wogonin	Inhibitor	99.92%	Unkown
HY-120350	BI-1347	Inhibitor	99.84%	Unkown
HY-126675A	AS2863619	Inhibitor	99.94%	Unkown
HY-101611	MSC2530818	Inhibitor	99.62%	Unkown
HY-111388A	SEL120-34A monohydrochloride	Inhibitor	99.29%	Unkown
HY-19984	CCT-251921	Inhibitor	99.01%	Unkown
HY-15681	Senexin A	Inhibitor	99.79%	Unkown
HY-122586	BRD6989	Inhibitor	99.56%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-12293	LY2857785	Inhibitor	99.92%	Unkown
HY-111518	JH-XI-10-02	Inhibitor	99.82%	Unkown
HY-111388B	SEL120-34A hydrochloride	Inhibitor	99.98%	Unkown
HY-145121	DS96432529	Inhibitor	99.58%	Unkown
HY-126675	AS2863619 free base	Inhibitor	99.87%	Unkown
HY-139875	JH-XVI-178	Inhibitor	98.16%	Unkown
HY-101800	Senexin B	Inhibitor	99.72%	Unkown
HY-151463	CDK8-IN-11	Inhibitor	98.20%	Unkown
HY-143889	Senexin C	Inhibitor	98.06%	Unkown
HY-149974	CDK8-IN-13	Inhibitor	99.14%	Unkown
HY-103492	CDK8-IN-1	Inhibitor	99.77%	Unkown
HY-111427	CDK8/19-IN-1	Inhibitor	98.03%	Unkown
HY-149209	LL-K8-22	Degrader	99.76%	Unkown
HY-X0009A	JSH-009 dimaleate	Inhibitor	/	Unkown
HY-111388	SEL120-34A	Inhibitor	/	Unkown
HY-15681A	Senexin A hydrochloride	Inhibitor	/	Unkown
HY-147716	CDK8-IN-6	Inhibitor	/	Unkown
HY-158377	CDK8/19-IN-2	Inhibitor	/	Unkown
HY-148561	CDK8-IN-12	Inhibitor	99.74%	Unkown
HY-N0400R	Wogonin (Standard)	Inhibitor	/	Unkown
HY-147527	CDK8-IN-5	Inhibitor	/	Unkown
HY-147717	CDK8-IN-7	Inhibitor	/	Unkown
HY-162600	CDK8-IN-15	Inhibitor	/	Unkown
HY-151371	CDK8-IN-10	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDK8	MGD	MGI:1196224
Felis catus	CDK8	VGNC	VGNC:60706
Rattus norvegicus	CDK8	RGD	RGD:1560888
Macaca mulatta	CDK8	VGNC	VGNC:70984
Canis familiaris	CDK8	VGNC	VGNC:39061
Bos taurus	CDK8	VGNC	VGNC:27135
Others	CDK8	NCBI

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