2. Cell Cycle/DNA Damage
  3. CDK
  4. CDK8-IN-1

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

For research use only. We do not sell to patients.

CDK8-IN-1 Chemical Structure

CDK8-IN-1 Chemical Structure

CAS No. : 1629633-48-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 309 In-stock
Solution
10 mM * 1 mL in DMSO USD 309 In-stock
Solid
1 mg USD 110 In-stock
5 mg USD 280 In-stock
10 mg USD 400 In-stock
25 mg USD 670 In-stock
50 mg USD 900 In-stock
100 mg USD 1200 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

CDK8-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

IC50 & Target[1]

CDK8

3 nM (IC50)

In Vivo

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

255.20

Formula

C11H8F3N3O
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

NC(C1=C(C(F)(F)F)C(C2=CC=NC=C2)=CN1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (391.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9185 mL 19.5925 mL 39.1850 mL
5 mM 0.7837 mL 3.9185 mL 7.8370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.77%

COA (252 KB) HNMR (258 KB) LCMS (256 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[1]

Mice[1]
CDK8-IN-1 is administrated to mice with 5 mg/kg, 25mg/mg by IV and PO respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9185 mL 19.5925 mL 39.1850 mL 97.9624 mL
5 mM 0.7837 mL 3.9185 mL 7.8370 mL 19.5925 mL
10 mM 0.3918 mL 1.9592 mL 3.9185 mL 9.7962 mL
15 mM 0.2612 mL 1.3062 mL 2.6123 mL 6.5308 mL
20 mM 0.1959 mL 0.9796 mL 1.9592 mL 4.8981 mL
25 mM 0.1567 mL 0.7837 mL 1.5674 mL 3.9185 mL
30 mM 0.1306 mL 0.6531 mL 1.3062 mL 3.2654 mL
40 mM 0.0980 mL 0.4898 mL 0.9796 mL 2.4491 mL
50 mM 0.0784 mL 0.3918 mL 0.7837 mL 1.9592 mL
60 mM 0.0653 mL 0.3265 mL 0.6531 mL 1.6327 mL
80 mM 0.0490 mL 0.2449 mL 0.4898 mL 1.2245 mL
100 mM 0.0392 mL 0.1959 mL 0.3918 mL 0.9796 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CDK8-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK8-IN-11629633-48-2CDKCyclin dependent kinaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CDK8-IN-1
Cat. No.:
HY-103492
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.