BCAS2 - BCAS2 pre-mRNA processing factor Gene

Homo sapiens

Also known as DAM1; SPF27; Snt309

Gene ID: 10286 | Gene type: protein coding

About BCAS2

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,567,557-114,581,615 (from NCBI)

This gene has 2 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in bone marrow (RPKM 27.2), brain (RPKM 25.4) and 25 other tissues.

Summary

Involved in mRNA splicing, via spliceosome. Located in centrosome and nuclear speck. Part of U2-type catalytic step 2 spliceosome. Colocalizes with DNA replication factor A complex. Implicated in breast Cancer. [provided by Alliance of Genome Resources, Apr 2022]

BCAS2 Products(1)

mRNA	Protein	Name
NM_005872.3	NP_005863.1	pre-mRNA-splicing factor SPF27

BCAS2 Protein Structure

BCAS2

0
100
200
225 a.a.

Protein Preferred Names

Protein Names

pre-mRNA-splicing factor SPF27

DNA amplified in mammary carcinoma 1 protein

Recombinant BCAS2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7649	BCAS2 Protein, Human (His, T7)	O75934 (A2-F225)	≥95%
HY-P700271	BCAS2 Protein, Human (N-GST)	O75934 (A2-F225)	≥95%

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01400	BCAS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BCAS2	VGNC	VGNC:106650
Canis familiaris	BCAS2	VGNC	VGNC:38399
Felis catus	BCAS2	VGNC	VGNC:69196
Mus musculus	BCAS2	MGD	MGI:1915433
Rattus norvegicus	BCAS2	RGD	RGD:1306485
Macaca mulatta	BCAS2	VGNC	VGNC:106322
Others	BCAS2	NCBI

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