SNRPC - small nuclear ribonucleoprotein polypeptide C Gene

Homo sapiens

Also known as U1C; Yhc1

Gene ID: 6631 | Gene type: protein coding

About SNRPC

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,757,505-34,773,857 (from NCBI)

This gene has 4 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in testis (RPKM 34.9), bone marrow (RPKM 32.7) and 25 other tissues.

Summary

This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009]

SNRPC Products(1)

mRNA	Protein	Name
NM_003093.3	NP_003084.1	U1 small nuclear ribonucleoprotein C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables U1 snRNA binding	IDA IDA: Inferred from direct assay	1826349	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8076607	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	8532530	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	8798632	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15312772	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	8972845	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	8972845	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	10068039	GOA
part of U1 snRNP	IDA IDA: Inferred from direct assay	15312772	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPC Protein Structure

zf-U1

0
100
159 a.a.

Protein Preferred Names

Protein Names

U1 small nuclear ribonucleoprotein C

U1 small nuclear RNP specific C

SNRPC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNRPC	P09234	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	SNRPC	P09234	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	SNRPC	P09234	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	SNRPC	P09234	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	32296183
Intra	SNRPC	P09234	BCAS2	Homo sapiens	O75934	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	BCAS2	Homo sapiens	O75934	Y2H Array	32296183
Intra	SNRPC	P09234	BCAS2	Homo sapiens	O75934	Anti Tag CoIP	35271311
Intra	SNRPC	P09234	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	SNRPC	P09234	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	SNRPC	P09234	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Array	32296183
Intra	SNRPC	P09234	NCKIPSD	Homo sapiens	Q9NZQ3-3	Validated Y2H	32296183
Intra	SNRPC	P09234	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	SNRPC	P09234	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	SNRPC	P09234	KRTAP13-2	Homo sapiens	Q52LG2	Validated Y2H	32296183
Intra	SNRPC	P09234	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Array	32296183
Intra	SNRPC	P09234	SPAG8	Homo sapiens	Q99932-2	Validated Y2H	32296183
Intra	SNRPC	P09234	SPAG8	Homo sapiens	Q99932-2	Y2H Array	32296183
Intra	SNRPC	P09234	SPAG8	Homo sapiens	Q99932-2	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	SNRPC	P09234	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	SNRPC	P09234	ACTMAP	Homo sapiens	Q5BKX5-3	Validated Y2H	32296183
Intra	SNRPC	P09234	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	SNRPC	P09234	BOLL	Homo sapiens	Q8N9W6-4	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	BOLL	Homo sapiens	Q8N9W6-4	Validated Y2H	32296183
Intra	SNRPC	P09234	BOLL	Homo sapiens	Q8N9W6-4	Y2H Array	32296183
Intra	SNRPC	P09234	RUNX1	Homo sapiens	Q01196-8	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	RUNX1	Homo sapiens	Q01196-8	Validated Y2H	32296183
Intra	SNRPC	P09234	RUNX1	Homo sapiens	Q01196-8	Y2H Array	32296183
Intra	SNRPC	P09234	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	SNRPC	P09234	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	SNRPC	P09234	UFSP1	Homo sapiens	Q6NVU6	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	UFSP1	Homo sapiens	Q6NVU6	Validated Y2H	32296183
Intra	SNRPC	P09234	UFSP1	Homo sapiens	Q6NVU6	Y2H Array	32296183
Intra	SNRPC	P09234	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	ANKRD10	Homo sapiens	Q9NXR5-2	Validated Y2H	32296183
Intra	SNRPC	P09234	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Array	32296183
Intra	SNRPC	P09234	FUBP1	Homo sapiens	Q96AE4-2	Validated Y2H	32296183
Intra	SNRPC	P09234	FUBP1	Homo sapiens	Q96AE4-2	Y2H Array	32296183
Intra	SNRPC	P09234	FUBP1	Homo sapiens	Q96AE4-2	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	FAM168B	Homo sapiens	A1KXE4-2	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	FAM168B	Homo sapiens	A1KXE4-2	Y2H Array	32296183
Intra	SNRPC	P09234	KRTAP19-2	Homo sapiens	Q3LHN2	Validated Y2H	32296183
Intra	SNRPC	P09234	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Array	32296183
Intra	SNRPC	P09234	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	PRR20D	Homo sapiens	P86480	Validated Y2H	32296183
Intra	SNRPC	P09234	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	SNRPC	P09234	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP19-6	Homo sapiens	Q3LI70	Validated Y2H	32296183
Intra	SNRPC	P09234	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Array	32296183
Intra	SNRPC	P09234	EYA2	Homo sapiens	O00167-2	Y2H Array	32296183
Intra	SNRPC	P09234	EYA2	Homo sapiens	O00167-2	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	STH	Homo sapiens	Q8IWL8	Y2H Array	32296183
Intra	SNRPC	P09234	STH	Homo sapiens	Q8IWL8	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	STH	Homo sapiens	Q8IWL8	Validated Y2H	32296183
Intra	SNRPC	P09234	CREM	Homo sapiens	Q03060-25	Y2H Array	32296183
Intra	SNRPC	P09234	CREM	Homo sapiens	Q03060-25	Validated Y2H	32296183
Intra	SNRPC	P09234	CREM	Homo sapiens	Q03060-25	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	TIA1	Homo sapiens	P31483	Anti Bait CoIP	12486009
Intra	SNRPC	P09234	TIA1	Homo sapiens	P31483	Pull Down	12486009
Intra	SNRPC	P09234	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Array	32296183
Intra	SNRPC	P09234	KRTAP7-1	Homo sapiens	Q8IUC3	Validated Y2H	32296183
Intra	SNRPC	P09234	KRTAP21-2	Homo sapiens	Q3LI59	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KRTAP21-2	Homo sapiens	Q3LI59	Validated Y2H	32296183
Intra	SNRPC	P09234	KRTAP21-2	Homo sapiens	Q3LI59	Y2H Array	32296183
Intra	SNRPC	P09234	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	SNRPC	P09234	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	MKRN3	Homo sapiens	Q13064	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	MKRN3	Homo sapiens	Q13064	Y2H Array	32296183
Intra	SNRPC	P09234	MKRN3	Homo sapiens	Q13064	Validated Y2H	32296183
Intra	SNRPC	P09234	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	35271311
Intra	SNRPC	P09234	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	SNRPC	P09234	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	SNRPC	P09234	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	HNRNPDL	Homo sapiens	O14979	Anti Tag CoIP	35271311
Intra	SNRPC	P09234	HNRNPDL	Homo sapiens	O14979	Y2H Array	32296183
Intra	SNRPC	P09234	HNRNPH1	Homo sapiens	P31943	Validated Y2H	32296183
Intra	SNRPC	P09234	HNRNPH1	Homo sapiens	P31943	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	HNRNPH1	Homo sapiens	P31943	Y2H Array	32296183
Intra	SNRPC	P09234	AKAP8L	Homo sapiens	Q9ULX6	Anti Tag CoIP	35271311
Intra	SNRPC	P09234	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	SNRPC	P09234	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	SNRPC	P09234	EXOSC8	Homo sapiens	Q96B26	Validated Y2H	32296183
Intra	SNRPC	P09234	EXOSC8	Homo sapiens	Q96B26	Y2H Array	32296183
Intra	SNRPC	P09234	EXOSC8	Homo sapiens	Q96B26	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	SNRPC	P09234	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
Intra	SNRPC	P09234	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
Intra	SNRPC	P09234	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	SNRPC	P09234	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	TRIB3	Homo sapiens	Q96RU7	Validated Y2H	32296183
Intra	SNRPC	P09234	ODAM	Homo sapiens	A1E959	Y2H Array	32296183
Intra	SNRPC	P09234	ODAM	Homo sapiens	A1E959	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
Intra	SNRPC	P09234	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
Intra	SNRPC	P09234	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	RBM10	Homo sapiens	P98175	Anti Tag CoIP	22365833
Intra	SNRPC	P09234	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	SNRPC	P09234	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	SNRPC	P09234	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	PLA2G10	Homo sapiens	O15496	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	PLA2G10	Homo sapiens	O15496	Y2H Array	32296183
Intra	SNRPC	P09234	RBPMS	Homo sapiens	Q93062-3	Validated Y2H	32296183
Intra	SNRPC	P09234	RBPMS	Homo sapiens	Q93062-3	Y2H Array	32296183
Intra	SNRPC	P09234	RBPMS	Homo sapiens	Q93062-3	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
Intra	SNRPC	P09234	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	SNRPC	P09234	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	SNRPC	P09234	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
Intra	SNRPC	P09234	HSD17B14	Homo sapiens	Q9BPX1	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	HSD17B14	Homo sapiens	Q9BPX1	Validated Y2H	32296183
Intra	SNRPC	P09234	HSD17B14	Homo sapiens	Q9BPX1	Y2H Array	32296183
Intra	SNRPC	P09234	SEC23B	Homo sapiens	Q15437	Validated Y2H	32296183
Intra	SNRPC	P09234	SEC23B	Homo sapiens	Q15437	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	SEC23B	Homo sapiens	Q15437	Y2H Array	32296183
Intra	SNRPC	P09234	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	SNRPC	P09234	RAMAC	Homo sapiens	Q9BTL3	Y2H Array	32296183
Intra	SNRPC	P09234	RAMAC	Homo sapiens	Q9BTL3	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	RAMAC	Homo sapiens	Q9BTL3	Validated Y2H	32296183
Intra	SNRPC	P09234	INTS11	Homo sapiens	Q5TA45	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	INTS11	Homo sapiens	Q5TA45	Validated Y2H	32296183
Intra	SNRPC	P09234	INTS11	Homo sapiens	Q5TA45	Y2H Array	32296183
Intra	SNRPC	P09234	ARHGAP9	Homo sapiens	Q9BRR9	Validated Y2H	32296183
Intra	SNRPC	P09234	ARHGAP9	Homo sapiens	Q9BRR9	Y2H Array	32296183
Intra	SNRPC	P09234	ARHGAP9	Homo sapiens	Q9BRR9	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KLF1	Homo sapiens	Q13351	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	KLF1	Homo sapiens	Q13351	Validated Y2H	32296183
Intra	SNRPC	P09234	KLF1	Homo sapiens	Q13351	Y2H Array	32296183
Intra	SNRPC	P09234	METTL27	Homo sapiens	Q8N6F8	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	METTL27	Homo sapiens	Q8N6F8	Y2H Array	32296183
Intra	SNRPC	P09234	METTL27	Homo sapiens	Q8N6F8	Validated Y2H	32296183
Intra	SNRPC	P09234	JMJD7	Homo sapiens	P0C870	Validated Y2H	32296183
Intra	SNRPC	P09234	JMJD7	Homo sapiens	P0C870	Y2H Array	32296183
Intra	SNRPC	P09234	JMJD7	Homo sapiens	P0C870	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	GIGYF1	Homo sapiens	O75420	Y2H Array	32296183
Intra	SNRPC	P09234	GIGYF1	Homo sapiens	O75420	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	ECM1	Homo sapiens	Q16610	Validated Y2H	32296183
Intra	SNRPC	P09234	ECM1	Homo sapiens	Q16610	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	ECM1	Homo sapiens	Q16610	Y2H Array	32296183
Intra	SNRPC	P09234	RERE	Homo sapiens	Q9P2R6	Y2H Prey Pooling	32296183
Intra	SNRPC	P09234	RERE	Homo sapiens	Q9P2R6	Validated Y2H	32296183
Intra	SNRPC	P09234	RERE	Homo sapiens	Q9P2R6	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

SNRPC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82581	U1C Antibody (YA2326)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13504	SNRPC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SNRPC	VGNC	VGNC:35078
Mus musculus	SNRPC	MGD	MGI:109489
Rattus norvegicus	SNRPC	RGD	RGD:1306065

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