HMG20B - high mobility group 20B Gene

Homo sapiens

Also known as SOXL; HMGX2; BRAF25; BRAF35; HMGXB2; PP7706; pp8857; SMARCE1r

Gene ID: 10362 | Gene type: protein coding

About HMG20B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,572,944-3,579,083 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and 20 paralogues. Ubiquitous expression in prostate (RPKM 40.0), kidney (RPKM 22.5) and 25 other tissues.

Summary

Predicted to enable DNA binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of protein sumoylation; positive regulation of neuron differentiation; and skeletal muscle cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

HMG20B Products(1)

mRNA	Protein	Name
NM_006339.3	NP_006330.2	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21399666	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMG20B Protein Structure

HMG_box

0
100
200
317 a.a.

Protein Preferred Names

Protein Names

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

BRCA2-associated factor 35

HMG20B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HMG20B	Q9P0W2	CCDC136	Homo sapiens	Q96JN2-2	Y2H Prey Pooling	25416956
Intra	HMG20B	Q9P0W2	CCDC136	Homo sapiens	Q96JN2-2	Validated Y2H	25416956
Intra	HMG20B	Q9P0W2	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	HMG20B	Q9P0W2	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
Intra	HMG20B	Q9P0W2	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	HMG20B	Q9P0W2	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	25416956
Intra	HMG20B	Q9P0W2	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
Intra	HMG20B	Q9P0W2	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	HMG20B	Q9P0W2	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	HMG20B	Q9P0W2	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	HMG20B	Q9P0W2	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	HMG20B	Q9P0W2	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	HMG20B	Q9P0W2	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	HMG20B	Q9P0W2	SNAPC5	Homo sapiens	O75971-2	Y2H Prey Pooling	32296183
Intra	HMG20B	Q9P0W2	SNAPC5	Homo sapiens	O75971-2	Y2H Array	32296183
Intra	HMG20B	Q9P0W2	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	HMG20B	Q9P0W2	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	HMG20B	Q9P0W2	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	HMG20B	Q9P0W2	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	HMG20B	Q9P0W2	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	HMG20B	Q9P0W2	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	HMG20B	Q9P0W2	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	HMG20B	Q9P0W2	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	HMG20B	Q9P0W2	SYCE1	Homo sapiens	Q8N0S2	Y2H Prey Pooling	25416956
Intra	HMG20B	Q9P0W2	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25416956
Intra	HMG20B	Q9P0W2	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	HMG20B	Q9P0W2	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	HMG20B	Q9P0W2	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	HMG20B	Q9P0W2	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	HMG20B	Q9P0W2	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	HMG20B	Q9P0W2	HMG20A	Homo sapiens	Q9NP66	Anti Tag CoIP	33961781
Intra	HMG20B	Q9P0W2	ERP29	Homo sapiens	P30040	Y2H Prey Pooling	32296183
Intra	HMG20B	Q9P0W2	ERP29	Homo sapiens	P30040	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2

Hypophosphatemic Nephrolithiasis/Osteoporosis 2	NPHLOP2
Nephrolithiasis-Osteoporosis, Hypophosphatemic, 2	Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 2

Frontonasal Dysplasia 2

FND2	Frontonasal Dysplasia With Alopecia And Genital Anomaly
Frontonasal Dysplasia-Alopecia-Genital Anomalies Syndrome	Alx4-Related Fndag
Craniofrontonasal Dysplasia With Alopecia And Hypogonadism	Frontonasal Dysplasia Type 2
Frontonasal Dysplasia With Alopecia And Genital Abnomality	Doid:0081046
Dysplasia, Frontonasal, Type 2

Barber-Say Syndrome

Hypertrichosis, Atrophic Skin, Ectropion, And Macrostomia	Barber Say Syndrome
BBRSAY	Bss
Hypertrichosis Atrophic Skin Ectropion Macrostomia	Hypertrichosis-Atrophic Skin-Ectropion-Macrostomia Syndrome

Coffin-Siris Syndrome 9

Mrd27	CSS9
Mental Retardation, Autosomal Dominant 27	Autosomal Dominant Mental Retardation 27
Autosomal Dominant Non-Syndromic Intellectual Disability 27	Coffin-Siris Syndrome, Type 9

Hypophosphatemic Nephrolithiasis/Osteoporosis

Nephrolithiasis/Osteoporosis, Hypophosphatemic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06229	HMG20B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HMG20B	VGNC	VGNC:41708
Felis catus	HMG20B	VGNC	VGNC:67593
Mus musculus	HMG20B	MGD	MGI:1341190
Rattus norvegicus	HMG20B	RGD	RGD:1309235

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