EIF3M - eukaryotic translation initiation factor 3 subunit M Gene

Homo sapiens

Also known as B5; GA17; PCID1; TANGO7; hfl-B5

Gene ID: 10480 | Gene type: protein coding

About EIF3M

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:32,583,831-32,606,264 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 68.3), thyroid (RPKM 54.3) and 25 other tissues.

Summary

This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in Cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]

EIF3M Products(2)

mRNA	Protein	Name
NM_001307929.2	NP_001294858.1	eukaryotic translation initiation factor 3 subunit M isoform 2
NM_006360.6	NP_006351.2	eukaryotic translation initiation factor 3 subunit M isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	25849773	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3M Protein Structure

PCI

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit M

B5 receptor

Recombinant EIF3M Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71577	EIF3M Protein, Human (His-SUMO)	Q7L2H7-1 (S2-T374)	≥95%

Related Diseases

Diseases

Alias

Colon Squamous Cell Carcinoma

Colonic Epidermoid Carcinoma	Squamous Cell Carcinoma Of Colon
Squamous Cell Carcinoma Of The Colon

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04269	EIF3M Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EIF3M	VGNC	VGNC:72095
Felis catus	EIF3M	VGNC	VGNC:61787
Rattus norvegicus	EIF3M	RGD	RGD:1565840
Mus musculus	EIF3M	MGD	MGI:1351744
Bos taurus	EIF3M	VGNC	VGNC:28403
Canis familiaris	EIF3M	VGNC	VGNC:40279
Others	EIF3M	NCBI

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