EIF3H - eukaryotic translation initiation factor 3 subunit H Gene

Homo sapiens

Also known as EIF3S3; eIF3-p40; eIF3-gamma

Gene ID: 8667 | Gene type: protein coding

About EIF3H

Cytogenetic location: 8q23.3-q24.11 Genomic coordinates (GRCh38): 8:116,642,130-116,766,374 (from NCBI)

This gene has 11 transcripts (splice variants), 220 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 170.8), thyroid (RPKM 126.9) and 25 other tissues.

Summary

Enables Deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate Cancer. [provided by Alliance of Genome Resources, Apr 2022]

EIF3H Products(1)

mRNA	Protein	Name
NM_003756.3	NP_003747.1	eukaryotic translation initiation factor 3 subunit H

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metal-dependent deubiquitinase activity	IDA IDA: Inferred from direct assay	32269044	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12812986	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	32269044	GOA
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3H Protein Structure

JAB

0
100
200
300
352 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit H

eIF-3-gamma

EIF3H Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3H	O15372	ABI1	Homo sapiens	Q8IZP0-5	Validated Y2H	32296183
Intra	EIF3H	O15372	ABI1	Homo sapiens	Q8IZP0-5	Y2H Prey Pooling	32296183
Intra	EIF3H	O15372	ABI1	Homo sapiens	Q8IZP0-5	Y2H Array	32296183
Intra	EIF3H	O15372	SORBS2	Homo sapiens	O94875-10	Validated Y2H	32296183
Intra	EIF3H	O15372	DISC1	Homo sapiens	Q9NRI5-1	Y2H	17043677
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	18599441
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	33961781
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	28514442
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	SLCA	18599441
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Anti Tag CoIP	19615732
Intra	EIF3H	O15372	EIF3M	Homo sapiens	Q7L2H7	Pull Down	23623729
Intra	EIF3H	O15372	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	19615732
Intra	EIF3H	O15372	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
Intra	EIF3H	O15372	DISC1	Homo sapiens	Q9NRI5	Y2H	12812986
Intra	EIF3H	O15372	EIF3F	Homo sapiens	O00303	Anti Tag CoIP	18599441
Intra	EIF3H	O15372	EIF3F	Homo sapiens	O00303	Pull Down	23623729
Intra	EIF3H	O15372	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	32296183
Intra	EIF3H	O15372	NCK2	Homo sapiens	O43639	Validated Y2H	32296183
Intra	EIF3H	O15372	NCK2	Homo sapiens	O43639	Y2H Array	32296183
Intra	EIF3H	O15372	SORBS3	Homo sapiens	O60504	Validated Y2H	32296183
Intra	EIF3H	O15372	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	EIF3H	O15372	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	EIF3H	O15372	ABI3	Homo sapiens	Q9P2A4	Y2H Pooling	16189514
Intra	EIF3H	O15372	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	EIF3H	O15372	EIF3CL	Homo sapiens	B5ME19	Anti Tag CoIP	33961781
Intra	EIF3H	O15372	EIF3CL	Homo sapiens	B5ME19	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Trichorhinophalangeal Syndrome, Type Ii

Langer-Giedion Syndrome	Lgs
Trichorhinophalangeal Syndrome Type Ii	Trichorhinophalangeal Syndrome Type 2
TRPS2	Monosomy 8q24.1
Chromosome 8q24.1 Deletion Syndrome	Deletion 8q24.1
Giedion-Langer Syndrome	Trichorhinophalangeal Dysplasia Type Ii
Langer Giedion Syndrome	Trps 2
Tricho-Rhino-Phalangeal Syndrome Type Ii	Trichorhinophalangeal Syndrome With Exostosis
Trps Ii	Tricho-Rhino-Phalangeal Syndrome 2
8q24.1 Microdeletion Syndrome	8q24.1 Deletion Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04264	EIF3H Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF3H	RGD	RGD:735178
Felis catus	EIF3H	VGNC	VGNC:81651
Mus musculus	EIF3H	MGD	MGI:1915385
Macaca mulatta	EIF3H	VGNC	VGNC:72189
Bos taurus	EIF3H	VGNC	VGNC:28398
Canis familiaris	EIF3H	VGNC	VGNC:40274

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