2. Gene
  3. SYNCRIP - synaptotagmin binding cytoplasmic RNA interacting protein Gene

SYNCRIP - synaptotagmin binding cytoplasmic RNA interacting protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PP68; NSAP1; GRYRBP; HNRNPQ; HNRPQ1; GRY-RBP; hnRNP-Q

Gene ID: 10492 | Gene type: protein coding

About SYNCRIP

Cytogenetic location: 6q14.3 Genomic coordinates (GRCh38): 6:85,607,784-85,643,870 (from NCBI)

This gene has 21 transcripts (splice variants), 279 orthologues, 24 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 21.7), appendix (RPKM 18.1) and 25 other tissues.

Summary

This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and Other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]

SYNCRIP Products(8)

mRNA Protein Name
NM_001159673.2 NP_001153145.1 heterogeneous nuclear ribonucleoprotein Q isoform 2
NM_001159674.2 NP_001153146.1 heterogeneous nuclear ribonucleoprotein Q isoform 3
NM_001159675.1 NP_001153147.1 heterogeneous nuclear ribonucleoprotein Q isoform 4
NM_001159676.1 NP_001153148.1 heterogeneous nuclear ribonucleoprotein Q isoform 5
NM_001159677.2 NP_001153149.1 heterogeneous nuclear ribonucleoprotein Q isoform 6
NM_001253771.2 NP_001240700.1 heterogeneous nuclear ribonucleoprotein Q isoform 7
NM_001410938.1 NP_001397867.1 heterogeneous nuclear ribonucleoprotein Q isoform 8
NM_006372.5 NP_006363.4 heterogeneous nuclear ribonucleoprotein Q isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12674497 GOA
Biological Process GO Annotation Evidence Reference Source
involved in CRD-mediated mRNA stabilization IDA
IDA: Inferred from direct assay
11051545 GOA
involved in CRD-mediated mRNA stabilization IMP
IMP: Inferred from mutant phenotype
19029303 GOA
involved in cellular response to type II interferon IDA
IDA: Inferred from direct assay
15479637 GOA
involved in mRNA modification IDA
IDA: Inferred from direct assay
11134005 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
IDA: Inferred from direct assay
11051545 GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
IDA: Inferred from direct assay
12881431 GOA
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
23071094 GOA
involved in negative regulation of translation IMP
IMP: Inferred from mutant phenotype
15479637 GOA
involved in positive regulation of cytoplasmic translation IDA
IDA: Inferred from direct assay
11051545 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CRD-mediated mRNA stability complex IDA
IDA: Inferred from direct assay
19029303 GOA
part of CRD-mediated mRNA stability complex IPI
IPI: Inferred from physical interaction
19029303 GOA
part of GAIT complex IDA
IDA: Inferred from direct assay
15479637 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in cytosol IDA
IDA: Inferred from direct assay
11051545 GOA
part of mCRD-mediated mRNA stability complex IPI
IPI: Inferred from physical interaction
11051545 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12881431 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
15479637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYNCRIP Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (164 - 229)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (245 - 306)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (340 - 401)

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  • 623 a.a.
Protein Preferred Names Protein Names

heterogeneous nuclear ribonucleoprotein Q

NS1-associated protein 1

SYNCRIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SYNCRIP O60506 PRMT8 Homo sapiens Q9NR22-2
Y2H Prey Pooling
25416956
Intra
SYNCRIP O60506 HNRNPD Homo sapiens Q14103-4
Y2H
12674497
Intra
SYNCRIP O60506 HABP4 Homo sapiens Q5JVS0
Pull Down
19523114
Intra
SYNCRIP O60506 HABP4 Homo sapiens Q5JVS0
Y2H
19523114
Intra
SYNCRIP O60506 PRMT8 Homo sapiens Q9NR22
Y2H Array
29892012
Intra
SYNCRIP O60506 PRMT1 Homo sapiens Q99873
Y2H
23455924
Intra
SYNCRIP O60506 PRMT1 Homo sapiens Q99873
Anti Tag CoIP
23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Myoblastoma

Benign Granular Cell Tumor
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Treacher Collins Syndrome 1

Treacher Collins Syndrome

Mandibulofacial Dysostosis

Treacher Collins-Franceschetti Syndrome

Tcof

Tcs

Mfd1

Franceschetti-Klein Syndrome

TCS1

Franceschetti Syndrome

Franceschetti-Zwahlen-Klein Syndrome

Zygoauromandibular Dysplasia

Treacher-Collins Syndrome

Mandibulofacial Dysostosis Without Limb Anomalies

Bilateral And Symmetric Oto-Mandibular Dysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14082 SYNCRIP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SYNCRIP MGD MGI:1891690
Canis familiaris SYNCRIP VGNC VGNC:47024
Rattus norvegicus SYNCRIP RGD RGD:1305683
Felis catus SYNCRIP VGNC VGNC:65881
Bos taurus SYNCRIP VGNC VGNC:35518
Macaca mulatta SYNCRIP VGNC VGNC:78141