DCTN2 - dynactin subunit 2 Gene

Homo sapiens

Also known as RBP50; DCTN50; HEL-S-77; DYNAMITIN

Gene ID: 10540 | Gene type: protein coding

About DCTN2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,530,051-57,547,192 (from NCBI)

This gene has 33 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in brain (RPKM 42.2), esophagus (RPKM 36.9) and 25 other tissues.

Summary

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or Other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

DCTN2 Products(7)

mRNA	Protein	Name
NM_001261412.2	NP_001248341.1	dynactin subunit 2 isoform 2
NM_001261413.2	NP_001248342.1	dynactin subunit 2 isoform 3
NM_001348065.2	NP_001334994.1	dynactin subunit 2 isoform 4
NM_001348066.2	NP_001334995.1	dynactin subunit 2 isoform 5
NM_001348067.2	NP_001334996.1	dynactin subunit 2 isoform 6
NM_001348068.2	NP_001334997.1	dynactin subunit 2 isoform 6
NM_006400.5	NP_006391.1	dynactin subunit 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10226031	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17139249	GOA
enables spectrin binding	IDA IDA: Inferred from direct assay	23704327	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	8647893	GOA
involved in mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	8647893	GOA
acts upstream of or within protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	24816561	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	8647893	GOA
part of dynactin complex	IDA IDA: Inferred from direct assay	8647893	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	8647893	GOA
located in vesicle	IDA IDA: Inferred from direct assay	20682791	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCTN2 Protein Structure

Dynamitin

0
100
200
300
401 a.a.

Protein Preferred Names

Protein Names

dynactin subunit 2

50 kDa dynein-associated polypeptide

DCTN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DCTN2	Q13561	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	32296183
Intra	DCTN2	Q13561	CENPH	Homo sapiens	Q9H3R5	Y2H Array	32296183
Intra	DCTN2	Q13561	BORCS6	Homo sapiens	Q96GS4	Y2H Prey Pooling	32296183
Intra	DCTN2	Q13561	BORCS6	Homo sapiens	Q96GS4	Validated Y2H	32296183
Intra	DCTN2	Q13561	BORCS6	Homo sapiens	Q96GS4	Anti Tag CoIP	33961781
Intra	DCTN2	Q13561	BORCS6	Homo sapiens	Q96GS4	Y2H Array	32296183
Intra	DCTN2	Q13561	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	DCTN2	Q13561	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	DCTN2	Q13561	RABGEF1	Homo sapiens	Q9UJ41-4	Validated Y2H	32296183
Intra	DCTN2	Q13561	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	DCTN2	Q13561	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	DCTN2	Q13561	VPS33A	Homo sapiens	Q96AX1	Validated Y2H	32814053
Intra	DCTN2	Q13561	VPS33A	Homo sapiens	Q96AX1	Y2H Array	32814053
Intra	DCTN2	Q13561	VPS33A	Homo sapiens	Q96AX1	Y2H Pooling	32814053
Intra	DCTN2	Q13561	CCDC172	Homo sapiens	P0C7W6	Y2H Array	31515488
Intra	DCTN2	Q13561	CCDC172	Homo sapiens	P0C7W6	Y2H Array	25416956
Cross	DCTN2	Q13561	y14_sars	Human SARS coronavirus	Q7TLC7	Y2H Pooling	22046132
Cross	DCTN2	Q13561	y14_sars	Human SARS coronavirus	Q7TLC7	Lumier	22046132
Cross	DCTN2	Q13561	ns6_sars	Human SARS coronavirus	P59634	Lumier	22046132
Cross	DCTN2	Q13561	ns6_sars	Human SARS coronavirus	P59634	Y2H Pooling	22046132
Intra	DCTN2	Q13561	BLOC1S1	Homo sapiens	P78537	Y2H Prey Pooling	32296183
Intra	DCTN2	Q13561	BLOC1S1	Homo sapiens	P78537	Y2H Array	32296183
Intra	DCTN2	Q13561	PDCD6	Homo sapiens	O75340	Anti Bait CoIP	26950892
Intra	DCTN2	Q13561	PDCD6	Homo sapiens	O75340	Anti Tag CoIP	26950892
Intra	DCTN2	Q13561	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	DCTN2	Q13561	GADD45A	Homo sapiens	P24522	Y2H Array	32296183
Intra	DCTN2	Q13561	GADD45A	Homo sapiens	P24522	Y2H Prey Pooling	32296183
Intra	DCTN2	Q13561	BLOC1S6	Homo sapiens	Q9UL45	Y2H Array	25416956
Intra	DCTN2	Q13561	BLOC1S6	Homo sapiens	Q9UL45	Y2H Prey Pooling	25416956
Intra	DCTN2	Q13561	BLOC1S2	Homo sapiens	Q6QNY1	Validated Y2H	32296183
Intra	DCTN2	Q13561	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Array	32296183
Intra	DCTN2	Q13561	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Prey Pooling	32296183
Intra	DCTN2	Q13561	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	DCTN2	Q13561	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
Intra	DCTN2	Q13561	CAPZA2	Homo sapiens	P47755	Anti Tag CoIP	35271311
Intra	DCTN2	Q13561	DCTN1	Homo sapiens	Q14203	TAP	27173435
Intra	DCTN2	Q13561	CAPZA2	Homo sapiens	P47755	TAP	27173435
Intra	DCTN2	Q13561	DCTN1	Homo sapiens	Q14203	Anti Tag CoIP	33961781
Intra	DCTN2	Q13561	DCTN1	Homo sapiens	Q14203	Anti Tag CoIP	35271311
Intra	DCTN2	Q13561	MAPRE3	Homo sapiens	Q9UPY8	Validated Y2H	27107012
Intra	DCTN2	Q13561	MAPRE3	Homo sapiens	Q9UPY8	SLC	27107012
Intra	DCTN2	Q13561	MAPRE3	Homo sapiens	Q9UPY8	BFG-2H	27107012
Intra	DCTN2	Q13561	RINT1	Homo sapiens	Q6NUQ1	Y2H Array	32296183
Intra	DCTN2	Q13561	RINT1	Homo sapiens	Q6NUQ1	Y2H Prey Pooling	32296183
Intra	DCTN2	Q13561	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	32296183
Intra	DCTN2	Q13561	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	DCTN2	Q13561	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	32296183
Intra	DCTN2	Q13561	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	32296183
Intra	DCTN2	Q13561	CEP44	Homo sapiens	Q9C0F1	Y2H Array	32296183
Intra	DCTN2	Q13561	COG3	Homo sapiens	Q96JB2-2	Validated Y2H	32296183
Intra	DCTN2	Q13561	COG3	Homo sapiens	Q96JB2-2	Y2H Array	32296183
Intra	DCTN2	Q13561	COG3	Homo sapiens	Q96JB2-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Neuronopathy, Distal Hereditary Motor, Type Viib

HMN7B	Hmn Viib
Dhmn7b	Neuropathy, Distal Hereditary Motor, Type Viib
Distal Hereditary Motor Neuronopathy Type 7b	Distal Hereditary Motor Neuropathy Type Viib
Neuronopathy, Distal Hereditary Motor, Type 7b	Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type Viib
Lower Motor Neuron Disease, Dynactin Type	Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7b
Harper-Young Myopathy	Neuronopathy, Distal Hereditary Motor, 7b
Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Type Viib	Lower Motor Neuron Disease Dynactin Type
Plmnd	Progressive Lower Motor Neuron Disease
Neuropathy, Motor, Distal, Hereditary, Type Viib

Distal Hereditary Motor Neuronopathy Type 7

Dhmn7	Dhmnvpy
Distal Spinal Muscular Atrophy With Vocal Cord Paralysis

Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03594	DCTN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DCTN2	VGNC	VGNC:71751
Felis catus	DCTN2	VGNC	VGNC:61378
Canis familiaris	DCTN2	VGNC	VGNC:39817
Rattus norvegicus	DCTN2	RGD	RGD:1303182
Mus musculus	DCTN2	MGD	MGI:107733
Bos taurus	DCTN2	VGNC	VGNC:27929
Others	DCTN2	NCBI

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