CENPC - centromere protein C Gene

Homo sapiens

Also known as MIF2; hcp-4; CENP-C; CENPC1

Gene ID: 1060 | Gene type: protein coding

About CENPC

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:67,468,762-67,545,503 (from NCBI)

This gene has 7 transcripts (splice variants) and 117 orthologues. Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 4.6) and 25 other tissues.

Summary

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]

CENPC Products(2)

mRNA	Protein	Name
NM_001362481.2	NP_001349410.1	centromere protein C isoform 2
NM_001812.4	NP_001803.2	centromere protein C isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19503796	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19503796	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromosome segregation	IMP IMP: Inferred from mutant phenotype	21529714	GOA
involved in kinetochore assembly	IMP IMP: Inferred from mutant phenotype	21529714	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21529714	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in condensed chromosome, centromeric region	IDA IDA: Inferred from direct assay	11682612	GOA
part of inner kinetochore	IPI IPI: Inferred from physical interaction	36085283	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	21529714	GOA
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	21529714	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

centromere protein C

CENP-C 1

CENPC Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CENPC	Q03188	CENPA	Homo sapiens	P49450	BiFC	19503796
Intra	CENPC	Q03188	CENPA	Homo sapiens	P49450	Anti Tag CoIP	19503796
Intra	CENPC	Q03188	DSN1	Homo sapiens	Q9H410	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	DSN1	Homo sapiens	Q9H410	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	PMF1	Homo sapiens	Q6P1K2	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	H1-5	Homo sapiens	P16401	Crosslink	30021884
Intra	CENPC	Q03188	PMF1	Homo sapiens	Q6P1K2	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	NDC80	Homo sapiens	O14777	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	NDC80	Homo sapiens	O14777	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	NUF2	Homo sapiens	Q9BZD4	Anti Tag CoIP	33961781
Intra	CENPC	Q03188	ACTA2	Homo sapiens	P62736	Anti Tag CoIP	28514442
Intra	CENPC	Q03188	NUF2	Homo sapiens	Q9BZD4	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

CENPC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82482	CENPC Antibody (YA2227)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency	HHF5
Familial Hyperinsulinemic Hypoglycemia 5	Hyperinsulinemic Hypoglycemia Due To Insr Deficiency
Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency	Congenital Hyperinsulinism
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Hyperinsulinemic Hypoglycemia Familial 5

Crest Syndrome

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Dyskinesia Of Esophagus

Esophageal Motility Disorders	Dyskinesia Of Oesophagus
Esophageal Dysmotility	Esophageal Motility Disorder
Oesophageal Dysmotility	Oesophageal Motor Disorder
Esophageal Spasm

Glanders

Farcy Pipes	Infection Due To Pseudomonas Mallei
Burkholderia Mallei	Burkholderia Mallei Infection
Equina	Equine Glanders
Farcy	Farcy Buds
Farcy Cords	Infection Due To Actinobacillus Mallei
Infection Due To Malleomyces Mallei	Maliasmus
Malleus	Farce
Actinobacillosis	Actinobacillus Infection

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02475	CENPC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CENPC	VGNC	VGNC:27174
Mus musculus	CENPC	MGD	MGI:99700
Canis familiaris	CENPC	VGNC	VGNC:39102
Rattus norvegicus	CENPC	RGD	RGD:1303061
Macaca mulatta	CENPC	VGNC	VGNC:71007
Felis catus	CENPC	VGNC	VGNC:60753

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