2. Gene
  3. ERP29 - endoplasmic reticulum protein 29 Gene

ERP29 - endoplasmic reticulum protein 29 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ERp28; ERp31; PDIA9; PDI-DB; C12orf8; HEL-S-107

Gene ID: 10961 | Gene type: protein coding

About ERP29

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,013,426-112,023,449 (from NCBI)

This gene has 5 transcripts (splice variants) and 136 orthologues. Ubiquitous expression in bone marrow (RPKM 73.5), prostate (RPKM 67.8) and 25 other tissues.

Summary

This gene encodes a protein which localizes to the lumen of the endoplasmic reticulum (ER). It is a member of the protein disulfide isomerase (PDI) protein family but lacks an active thioredoxin motif, suggesting that this protein does not function as a disulfide isomerase. The canonical protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

ERP29 Products(2)

mRNA Protein Name
NM_001034025.2 NP_001029197.1 endoplasmic reticulum resident protein 29 isoform 2 precursor
NM_006817.4 NP_006808.1 endoplasmic reticulum resident protein 29 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22665516 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
22064321 GOA
involved in negative regulation of protein secretion IDA
IDA: Inferred from direct assay
22064321 GOA
acts upstream of or within positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
22064321 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
22064321 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
22064321 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
19995400 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
9738895 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERP29 Protein Structure

ERp29_N

ERp29_N: ERp29, N-terminal domain (33 - 155)

ERp29

ERp29: Endoplasmic reticulum protein ERp29, C-terminal domain (156 - 252)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

endoplasmic reticulum resident protein 29

endoplasmic reticulum lumenal protein ERp28

ERP29 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ERP29 P30040 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
Intra
ERP29 P30040 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra
ERP29 P30040 SLC35B4 Homo sapiens Q969S0
Validated Y2H
32296183
Intra
ERP29 P30040 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
ERP29 P30040 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
Intra
ERP29 P30040 ADIPOQ Homo sapiens Q15848
Validated Y2H
32296183
Intra
ERP29 P30040 TSPO2 Homo sapiens Q5TGU0
Validated Y2H
32296183
Intra
ERP29 P30040 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
ERP29 P30040 DESI1 Homo sapiens Q6ICB0
Validated Y2H
32296183
Intra
ERP29 P30040 HMG20B Homo sapiens Q9P0W2
Validated Y2H
32296183
Intra
ERP29 P30040 HMG20B Homo sapiens Q9P0W2
Y2H Prey Pooling
32296183
Intra
ERP29 P30040 HMG20B Homo sapiens Q9P0W2
Y2H Array
32296183
Intra
ERP29 P30040 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
ERP29 P30040 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
ERP29 P30040 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
ERP29 P30040 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
ERP29 P30040 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
ERP29 P30040 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
ERP29 P30040 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERP29 Proteins

Cat. No. Product Name Accession Purity
HY-P71686 ERP29 Protein, Human (GST) P30040-1 (P40-F251) ≥95%

ERP29 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82048 ERp29 Antibody (YA1793) WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Pharynx Squamous Cell Carcinoma
Gallbladder Adenocarcinoma

Adenocarcinoma Of The Gallbladder

Carcinoma Of The Gallbladder
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04514 ERP29 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ERP29 VGNC VGNC:40468
Felis catus ERP29 VGNC VGNC:80440
Bos taurus ERP29 VGNC VGNC:28596
Rattus norvegicus ERP29 RGD RGD:619781
Mus musculus ERP29 MGD MGI:1914647
Others ERP29 NCBI