TSPO2 - translocator protein 2 Gene

Homo sapiens

Also known as BZRPL1

Gene ID: 222642 | Gene type: protein coding

About TSPO2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,041,386-41,044,337 (from NCBI)

This gene has 3 transcripts (splice variants), 165 orthologues and 1 paralogue. Biased expression in bone marrow (RPKM 6.9) and testis (RPKM 0.2).

Summary

Predicted to enable Cholesterol binding activity. Involved in amino acid import across plasma membrane. Located in organelle membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TSPO2 Products(2)

mRNA	Protein	Name
NM_001010873.3	NP_001010873.1	translocator protein 2
NM_001159726.1	NP_001153198.1	translocator protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5-aminolevulinic acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	31989647	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 5-aminolevulinic acid import across plasma membrane	IMP IMP: Inferred from mutant phenotype	31989647	GOA
involved in import across plasma membrane	IDA IDA: Inferred from direct assay	27641616	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in organelle membrane	IDA IDA: Inferred from direct assay	27641616	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	27641616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPO2 Protein Structure

TspO_MBR

0
100
170 a.a.

Protein Preferred Names

Protein Names

translocator protein 2

benzodiazapine receptor (peripheral)-like 1

TSPO2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSPO2	Q5TGU0	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	RELL2	Homo sapiens	Q8NC24	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	RELL2	Homo sapiens	Q8NC24	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	RELL2	Homo sapiens	Q8NC24	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	MARCHF2	Homo sapiens	Q9P0N8	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	GGT7	Homo sapiens	Q9UJ14	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	GGT7	Homo sapiens	Q9UJ14	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	GGT7	Homo sapiens	Q9UJ14	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	SPAG4	Homo sapiens	Q9NPE6	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	AHNAK2	Homo sapiens	Q8IVF2-3	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	AHNAK2	Homo sapiens	Q8IVF2-3	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	FXYD3	Homo sapiens	Q14802-3	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	FXYD3	Homo sapiens	Q14802-3	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	ASZ1	Homo sapiens	Q8WWH4	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	ASZ1	Homo sapiens	Q8WWH4	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	ASZ1	Homo sapiens	Q8WWH4	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	ASGR2	Homo sapiens	P07307-3	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	ASGR2	Homo sapiens	P07307-3	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	SLC34A2	Homo sapiens	O95436-2	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	SLC34A2	Homo sapiens	O95436-2	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	DKK4	Homo sapiens	Q9UBT3	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	DKK4	Homo sapiens	Q9UBT3	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	DKK4	Homo sapiens	Q9UBT3	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	CNR2	Homo sapiens	P34972	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	CNR2	Homo sapiens	P34972	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	CD69	Homo sapiens	Q07108	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	CD69	Homo sapiens	Q07108	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	MFSD6	Homo sapiens	Q6ZSS7	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	MFSD6	Homo sapiens	Q6ZSS7	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	MFSD6	Homo sapiens	Q6ZSS7	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	FCGR1A	Homo sapiens	P12314	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	FCGR1A	Homo sapiens	P12314	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	LRRC59	Homo sapiens	Q96AG4	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	LRRC59	Homo sapiens	Q96AG4	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	LRRC59	Homo sapiens	Q96AG4	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	TMEM54	Homo sapiens	Q969K7	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	EMP1	Homo sapiens	P54849	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	CD53	Homo sapiens	P19397	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	CD53	Homo sapiens	P19397	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	SLC41A3	Homo sapiens	Q96GZ6	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	SLC41A3	Homo sapiens	Q96GZ6	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	SLC41A3	Homo sapiens	Q96GZ6	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	VSIR	Homo sapiens	Q9H7M9	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	VSIR	Homo sapiens	Q9H7M9	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	VSIR	Homo sapiens	Q9H7M9	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	SYT2	Homo sapiens	Q8N9I0	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	SYT2	Homo sapiens	Q8N9I0	Validated Y2H	32296183
Intra	TSPO2	Q5TGU0	SYT2	Homo sapiens	Q8N9I0	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	ERP29	Homo sapiens	P30040	Y2H Array	32296183
Intra	TSPO2	Q5TGU0	ERP29	Homo sapiens	P30040	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183
Intra	TSPO2	Q5TGU0	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15178	TSPO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSPO2	RGD	RGD:1594018
Bos taurus	TSPO2	VGNC	VGNC:55923
Felis catus	TSPO2	VGNC	VGNC:102542
Canis familiaris	TSPO2	VGNC	VGNC:49105
Mus musculus	TSPO2	MGD	MGI:1917276
Macaca mulatta	TSPO2	VGNC	VGNC:83960

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