ADRM1 - ADRM1 26S proteasome ubiquitin receptor Gene

Homo sapiens

Also known as ARM1; ARM-1; GP110; PSMD16

Gene ID: 11047 | Gene type: protein coding

About ADRM1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,302,896-62,308,862 (from NCBI)

This gene has 5 transcripts (splice variants) and 260 orthologues. Ubiquitous expression in testis (RPKM 31.4), fat (RPKM 17.5) and 25 other tissues.

Summary

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the Proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating Enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

ADRM1 Products(4)

mRNA	Protein	Name
NM_001281437.1	NP_001268366.1	proteasomal ubiquitin receptor ADRM1 isoform 2
NM_001281438.1	NP_001268367.1	proteasomal ubiquitin receptor ADRM1 isoform 2
NM_007002.4	NP_008933.2	proteasomal ubiquitin receptor ADRM1 isoform 1
NM_175573.2	NP_783163.1	proteasomal ubiquitin receptor ADRM1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activator activity	IDA IDA: Inferred from direct assay	16990800	GOA
enables molecular function inhibitor activity	EXP EXP: Inferred from Experiment	20471946	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	18922472	GOA
enables proteasome binding	IDA IDA: Inferred from direct assay	18162577	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteasome assembly	IDA IDA: Inferred from direct assay	16990800	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of proteasome complex	IDA IDA: Inferred from direct assay	16990800	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADRM1 Protein Structure

Proteasom_Rpn13

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

proteasomal ubiquitin receptor ADRM1

110 kDa cell membrane glycoprotein

ADRM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ADRM1	Q16186	UCHL5	Homo sapiens	Q9Y5K5	Imaging	17139257
Intra	ADRM1	Q16186	UCHL5	Homo sapiens	Q9Y5K5	Y2H Array	31515488
Intra	ADRM1	Q16186	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	16990800
Intra	ADRM1	Q16186	UCHL5	Homo sapiens	Q9Y5K5	Pull Down	18922472
Intra	ADRM1	Q16186	UCHL5	Homo sapiens	Q9Y5K5	Y2H Array	25416956
Intra	ADRM1	Q16186	UCHL5	Homo sapiens	Q9Y5K5	Pull Down	17139257
Intra	ADRM1	Q16186	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	18922472
Intra	ADRM1	Q16186	UCHL5	Homo sapiens	Q9Y5K5-3	Validated Y2H	27107012
Intra	ADRM1	Q16186	UBC	Homo sapiens	P0CG48	Pull Down	20059542
Intra	ADRM1	Q16186	UBC	Homo sapiens	P0CG48	X-Ray Diffraction	31064842
Intra	ADRM1	Q16186	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	16990800
Intra	ADRM1	Q16186	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	33961781
Intra	ADRM1	Q16186	PSMD2	Homo sapiens	Q13200	Anti Tag CoIP	28514442
Intra	ADRM1	Q16186	PSMD1	Homo sapiens	Q99460	X-Ray Diffraction	31064842
Intra	ADRM1	Q16186	PSMD1	Homo sapiens	Q99460	Anti Tag CoIP	33961781
Intra	ADRM1	Q16186	PSMD1	Homo sapiens	Q99460	FPS	31064842
Intra	ADRM1	Q16186	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	16990800
Intra	ADRM1	Q16186	PSMD4	Homo sapiens	P55036	BN-PAGE	24811749
Intra	ADRM1	Q16186	PSMD4	Homo sapiens	P55036	Anti Tag CoIP	28514442
Cross	ADRM1	Q16186	DSK2	Saccharomyces cerevisiae	P48510	Pull Down	20059542
Intra	ADRM1	Q16186	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	16713569
Intra	ADRM1	Q16186	UBQLN1	Homo sapiens	Q9UMX0	Pull Down	20059542
Intra	ADRM1	Q16186	UBQLN2	Homo sapiens	Q9UHD9	NMR	18497817
Intra	ADRM1	Q16186	UBQLN2	Homo sapiens	Q9UHD9	Pull Down	20059542
Intra	ADRM1	Q16186	UBQLN2	Homo sapiens	Q9UHD9	BN-PAGE	24811749
Intra	ADRM1	Q16186	RAD23B	Homo sapiens	P54727	Pull Down	20059542

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00417	ADRM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADRM1	VGNC	VGNC:59659
Rattus norvegicus	ADRM1	RGD	RGD:69248
Canis familiaris	ADRM1	VGNC	VGNC:37678
Mus musculus	ADRM1	MGD	MGI:1929289
Macaca mulatta	ADRM1	VGNC	VGNC:69613
Bos taurus	ADRM1	VGNC	VGNC:25699

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