DMC1 - DNA meiotic recombinase 1 Gene

Homo sapiens

Also known as DMC1H; LIM15; dJ199H16.1

Gene ID: 11144 | Gene type: protein coding

About DMC1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,509,147-38,570,183 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues, 6 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 4.8), lymph node (RPKM 0.7) and 8 other tissues.

Summary

This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

DMC1 Products(3)

mRNA	Protein	Name
NM_001278208.2	NP_001265137.1	meiotic recombination protein DMC1/LIM15 homolog isoform 2
NM_001363017.2	NP_001349946.1	meiotic recombination protein DMC1/LIM15 homolog isoform 2
NM_007068.4	NP_008999.2	meiotic recombination protein DMC1/LIM15 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent activity, acting on DNA	IDA IDA: Inferred from direct assay	15899844	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17541404	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in reciprocal meiotic recombination	IDA IDA: Inferred from direct assay	21307306	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22899867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DMC1 Protein Structure

Rad51

0
100
200
300
340 a.a.

Protein Preferred Names

Protein Names

meiotic recombination protein DMC1/LIM15 homolog

DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination

Related Diseases

Diseases

Alias

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Infertility

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03822	DMC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DMC1	VGNC	VGNC:71931
Bos taurus	DMC1	VGNC	VGNC:28105
Canis familiaris	DMC1	VGNC	VGNC:39998
Mus musculus	DMC1	MGD	MGI:105393
Felis catus	DMC1	VGNC	VGNC:83867
Rattus norvegicus	DMC1	RGD	RGD:1307611

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