MAP4K1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

Homo sapiens

Also known as HPK1

Gene ID: 11184 | Gene type: protein coding

About MAP4K1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,587,641-38,617,953 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 197 orthologues and 35 paralogues. Biased expression in lymph node (RPKM 28.4), spleen (RPKM 19.4) and 10 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MAP4K1 Products(3)

mRNA	Protein	Name
NM_007181.6	NP_009112.1	mitogen-activated protein kinase kinase kinase kinase 1 isoform 2
XM_011526404.2	XP_011524706.1	mitogen-activated protein kinase kinase kinase kinase 1 isoform X1
NM_001042600.3	NP_001036065.1	mitogen-activated protein kinase kinase kinase kinase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	8824585	GOA
enables MAP kinase kinase kinase kinase activity	IDA IDA: Inferred from direct assay	11053428	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9346925	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8824585	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	8824585	GOA
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	24362026	GOA
involved in cellular response to phorbol 13-acetate 12-myristate	IDA IDA: Inferred from direct assay	8824585	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	11053428	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11053428	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	8824585	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8824585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP4K1 Protein Structure

Pkinase

CNH

0
200
400
600
833 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase kinase 1

MAPK/ERK kinase kinase kinase 1	MEK kinase kinase 1
MEKKK 1	hematopoietic progenitor kinase 1

Related Diseases

Diseases

Alias

Melnick-Needles Syndrome

MNS	Melnick-Needles Osteodysplasty
Osteodysplasty Of Melnick And Needles	Osteochondrodysplasias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138568	HPK1-IN-3	Inhibitor	99.32%	Unkown
HY-138742	HPK1-IN-7	Inhibitor	99.33%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-143868	HPK1-IN-27	Inhibitor	/	Unkown
HY-143871	HPK1-IN-30	Inhibitor	/	Unkown
HY-156509	HPK1-IN-38	Inhibitor	/	Unkown
HY-169199	BAY-405	Inhibitor	/	Unkown
HY-RS08071	MAP4K1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08072	Map4k1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08073	Map4k1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAP4K1	MGD	MGI:1346882
Bos taurus	MAP4K1	VGNC	VGNC:31204
Rattus norvegicus	MAP4K1	RGD	RGD:1305463
Felis catus	MAP4K1	VGNC	VGNC:97498
Canis familiaris	MAP4K1	VGNC	VGNC:42981
Others	MAP4K1	NCBI

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