MAP4K1 - mitogen-activated protein kinase kinase kinase kinase 1 Gene

Homo sapiens

Also known as HPK1

Gene ID: 11184 | Gene type: protein coding

About MAP4K1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,587,641-38,617,953 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 197 orthologues and 35 paralogues. Biased expression in lymph node (RPKM 28.4), spleen (RPKM 19.4) and 10 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MAP4K1 Products(3)

mRNA	Protein	Name
NM_007181.6	NP_009112.1	mitogen-activated protein kinase kinase kinase kinase 1 isoform 2
XM_011526404.2	XP_011524706.1	mitogen-activated protein kinase kinase kinase kinase 1 isoform X1
NM_001042600.3	NP_001036065.1	mitogen-activated protein kinase kinase kinase kinase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	8824585	GOA
enables MAP kinase kinase kinase kinase activity	IDA IDA: Inferred from direct assay	11053428	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9346925	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8824585	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in JNK cascade	IDA IDA: Inferred from direct assay	8824585	GOA
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	24362026	GOA
involved in cellular response to phorbol 13-acetate 12-myristate	IDA IDA: Inferred from direct assay	8824585	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	11053428	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11053428	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	8824585	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8824585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP4K1 Protein Structure

Pkinase

CNH

0
200
400
600
833 a.a.

Protein Preferred Names

Protein Names

mitogen-activated protein kinase kinase kinase kinase 1

MAPK/ERK kinase kinase kinase 1	MEK kinase kinase 1
MEKKK 1	hematopoietic progenitor kinase 1

MAP4K1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAP4K1	Q92918	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	MAP4K1	Q92918	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	MAP4K1	Q92918	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	MAP4K1	Q92918	ABL1	Homo sapiens	P00519	Peptide Array	17474147
Intra	MAP4K1	Q92918	ABL1	Homo sapiens	P00519	Y2H	9346925
Intra	MAP4K1	Q92918	NCK1	Homo sapiens	P16333	Pull Down	9346925
Intra	MAP4K1	Q92918	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	MAP4K1	Q92918	NCK1	Homo sapiens	P16333	Y2H	9346925
Intra	MAP4K1	Q92918	GRB2	Homo sapiens	P62993	Pull Down	9346925
Intra	MAP4K1	Q92918	GRB2	Homo sapiens	P62993	SPR	9346925
Intra	MAP4K1	Q92918	GRB2	Homo sapiens	P62993	Y2H	9346925
Intra	MAP4K1	Q92918	GRB2	Homo sapiens	P62993	Pull Down	32707033
Intra	MAP4K1	Q92918	GRB2	Homo sapiens	P62993	Anti Bait CoIP	9346925
Intra	MAP4K1	Q92918	SLAMF1	Homo sapiens	Q13291	Pull Down	20231852
Intra	MAP4K1	Q92918	SLAMF1	Homo sapiens	Q13291	Anti Bait CoIP	20231852
Intra	MAP4K1	Q92918	FYN	Homo sapiens	P06241	Peptide Array	17474147
Intra	MAP4K1	Q92918	PLCG1	Homo sapiens	P19174	Anti Bait CoIP	17474147
Intra	MAP4K1	Q92918	PLCG1	Homo sapiens	P19174	Fluorescence	17474147
Intra	MAP4K1	Q92918	PIK3R1	Homo sapiens	P27986	Peptide Array	17474147
Intra	MAP4K1	Q92918	CRK	Homo sapiens	P46108	Peptide Array	17474147
Intra	MAP4K1	Q92918	CRKL	Homo sapiens	P46109	CoIP	9788432

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Melnick-Needles Syndrome

MNS	Melnick-Needles Osteodysplasty
Osteodysplasty Of Melnick And Needles	Osteochondrodysplasias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138568	HPK1-IN-3	Inhibitor	99.32%	Unkown
HY-138742	HPK1-IN-7	Inhibitor	99.33%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-148061	DB1113		99.28%	Unkown
HY-143868	HPK1-IN-27	Inhibitor	/	Unkown
HY-143871	HPK1-IN-30	Inhibitor	/	Unkown
HY-156509	HPK1-IN-38	Inhibitor	/	Unkown
HY-169199	BAY-405	Inhibitor	/	Unkown
HY-170443	PF-07265028	Inhibitor	/	Unkown
HY-RS08071	MAP4K1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08072	Map4k1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08073	Map4k1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAP4K1	MGD	MGI:1346882
Bos taurus	MAP4K1	VGNC	VGNC:31204
Rattus norvegicus	MAP4K1	RGD	RGD:1305463
Felis catus	MAP4K1	VGNC	VGNC:97498
Canis familiaris	MAP4K1	VGNC	VGNC:42981
Others	MAP4K1	NCBI

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