CGAS - cyclic GMP-AMP synthase Gene

Homo sapiens

Also known as MB21D1; h-cGAS; C6orf150

Gene ID: 115004 | Gene type: protein coding

About CGAS

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,423,711-73,452,297 (from NCBI)

This gene has 4 transcripts (splice variants), 185 orthologues and 9 paralogues.

Summary

Enables several functions, including 2',3'-cyclic GMP-AMP synthase activity; chromatin binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of defense response. Located in several cellular components, including cytosol; nucleus; and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]

CGAS Products(3)

mRNA	Protein	Name
NM_138441.3	NP_612450.2	cyclic GMP-AMP synthase isoform 1
XM_047418159.1	XP_047274115.1	cyclic GMP-AMP synthase isoform X1
NM_001410911.1	NP_001397840.1	cyclic GMP-AMP synthase isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2',3'-cyclic GMP-AMP synthase activity	EXP EXP: Inferred from Experiment	23258412	GOA
enables 2',3'-cyclic GMP-AMP synthase activity	IDA IDA: Inferred from direct assay	23258413	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	23258413	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	28738408	GOA
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	24077100	GOA
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	32911482	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	32911482	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	30827685	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26046437	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	29426904	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	28738408	GOA
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	23258413	GOA
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	23258413	GOA
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	23258413	GOA
involved in cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	32911482	GOA
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	23258413	GOA
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	23258413	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	23258413	GOA
involved in negative regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	32911482	GOA
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	30356214	GOA
involved in paracrine signaling	IDA IDA: Inferred from direct assay	24077100	GOA
involved in pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	23258413	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	23929945	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	23258413	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	24077100	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	23258413	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	32912999	GOA
located in cytosol	IDA IDA: Inferred from direct assay	23258413	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	38418882	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29937271	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	30827685	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	30356214	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CGAS Protein Structure

Mab-21

0
100
200
300
400
522 a.a.

Protein Preferred Names

Protein Names

cyclic GMP-AMP synthase

2'3'-cGAMP synthase	Mab-21 domain containing 1
cGAMP synthase	mab-21 domain-containing protein 1
protein MB21D1

Recombinant CGAS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71597	cGAS Protein, Human (His-SUMO)	Q8N884-1 (G161-F522)	≥95%
HY-P72337	cGAS Protein, Human (His)	Q8N884-1 (M1-F522)	≥95%

Related Diseases

Diseases

Alias

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Encephalopathy With Basal Ganglia Calcification	Aicardi-Goutières Syndrome
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Covid-19

2019 Novel Coronavirus	2019-Ncov Infection
Covid19	Sars-Cov-2 Infection
Wuhan Coronavirus Infection	Wuhan Seafood Market Pneumonia Virus Infection

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Sting-Associated Vasculopathy With Onset In Infancy

Savi	Sting-Associated Vasculopathy, Infantile Onset
Sting-Associated Vasculopathy, Infantile-Onset

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Crv	Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations
Rvcl	Rvcl-S
Vasculopathy, Retinal, With Cerebral Leukodystrophy	Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Retinal Vasculopathy With Cerebral Leukodystrophy	Retinal Vasculopathy And Cerebral Leukoencephalopathy
Hereditary Vascular Retinopathy	Hvr
RVCLS	Cerebroretinal Vasculopathy, Hereditary
Cerebroretinal Vasculopathy	Herns
Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly	Hereditary Cerebroretinal Vasculopathy
Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke	Hereditary Systemic Angiopathy
Hsa	Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations
Adrvcl	Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy
Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke	Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Huntington Disease

Huntington'S Disease	Huntington Chorea
HD	Huntington'S Chorea
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Severe Covid-19

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-160406	SNX281	Agonist	99.08%	Phase 1

Pre-clinical Phase

Bioactive Molecules (43)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114180	RU.521	Inhibitor	99.95%	Unkown
HY-131454	SR-717	Agonist	99.89%	Unkown
HY-133916	G140	Inhibitor	98.11%	Unkown
HY-128583	G150	Inhibitor	99.12%	Unkown
HY-150751	ODN TTAGGG	Antagonist	99.87%	Unkown
HY-114182	PF-06928215	Inhibitor	99.69%	Unkown
HY-139056	SU0268	Inhibitor	99.96%	Unkown
HY-W021040	Fludioxonil		99.94%	Unkown
HY-123230	Trifloxystrobin	Inhibitor	99.49%	Unkown
HY-114181	IRAK4-IN-4	Inhibitor	99.85%	Unkown
HY-150751C	ODN TTAGGG sodium	Antagonist	99.87%	Unkown
HY-149526	cGAS-IN-1	Inhibitor	98.29%	Unkown
HY-160546	cGAS-IN-2	Inhibitor	99.67%	Unkown
HY-B1331	Cyromazine		99.79%	Unkown
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium	Activator	/	Unkown
HY-158045	PROTAC PARP1 degrader-1	Inhibitor	99.86%	Unkown
HY-164288	TDI-6570	Inhibitor	99.64%	Unkown
HY-131454A	SR-717 free acid	Agonist	/	Unkown
HY-118578	Furalaxyl	Inhibitor	/	Unkown
HY-123230R	Trifloxystrobin (Standard)	Inhibitor	/	Unkown
HY-123230S	Trifloxystrobin-d6	Inhibitor	/	Unkown
HY-13735H	Quinacrine acetate		/	Unkown
HY-144328	STING agonist-10	Activator	/	Unkown
HY-144329	STING agonist-11	Activator	/	Unkown
HY-150751A	Biotin-labeled ODN TTAGGG sodium		/	Unkown
HY-150751B	FITC-labeled ODN TTAGGG sodium	Antagonist	/	Unkown
HY-158126	G-quadruplex ligand 2	Inhibitor	/	Unkown
HY-162133	MSA-2-Pt	Agonist	/	Unkown
HY-162459	cGAS-IN-3	Inhibitor	/	Unkown
HY-162944	NA-Ir		/	Unkown
HY-162967	MS8588		/	Unkown
HY-163461	4F-DDC	Inhibitor	/	Unkown
HY-N12507	Eupenicisirenin C	Inhibitor	/	Unkown
HY-P3041	Chromostatin (bovine)	Inhibitor	/	Unkown
HY-RS02575	CGA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02576	CGAS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02577	Cgas Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02578	Cgas Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-114730	CGA-JK3	Inhibitor	/	Unkown
HY-12464	Butafenacil	Inhibitor	/	Unkown
HY-132221	CU-32	Inhibitor	/	Unkown
HY-79648S	Fmoc-Methylalanine-d3		/	Unkown
HY-W020788	Benoxacor	Agonist	99.39%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CGAS	VGNC	VGNC:43047
Rattus norvegicus	CGAS	RGD	RGD:1586939
Bos taurus	CGAS	VGNC	VGNC:31271
Felis catus	CGAS	VGNC	VGNC:60830
Macaca mulatta	CGAS	VGNC	VGNC:71069
Mus musculus	CGAS	MGD	MGI:2442261
Others	CGAS	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.