Comp - cartilage oligomeric matrix protein Gene

Mus musculus

Also known as TSP5

Gene ID: 12845 | Gene type: protein coding

About Comp

Summary

Enables BMP binding activity; Integrin binding activity; and protease binding activity. Acts upstream of or within several processes, including animal organ development; chondrocyte proliferation; and vasculature development. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including connective tissue; embryo mesenchyme; notochord; placenta; and skeletal system. Used to study multiple epiphyseal dysplasia and pseudoachondroplasia. Human ortholog(s) of this gene implicated in carpal tunnel syndrome; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to human COMP (cartilage oligomeric matrix protein). [provided by Alliance of Genome Resources, Apr 2022]

Comp Products(1)

mRNA	Protein	Name
NM_016685.2	NP_057894.2	cartilage oligomeric matrix protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BMP binding	IPI IPI: Inferred from physical interaction	21350216	MGI
enables integrin binding	IPI IPI: Inferred from physical interaction	27151399	MGI
enables protease binding	IPI IPI: Inferred from physical interaction	16611630	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16611630	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	21350216	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	17588960	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	27151399	MGI
acts upstream of or within blood coagulation	IMP IMP: Inferred from mutant phenotype	26045608	MGI
acts upstream of or within bone growth	IMP IMP: Inferred from mutant phenotype	17588960	MGI
acts upstream of or within bone mineralization	IMP IMP: Inferred from mutant phenotype	27151399	MGI
acts upstream of or within bone morphogenesis	IGI IGI: Inferred from genetic interaction	18191556	MGI
acts upstream of or within cartilage development	IGI IGI: Inferred from genetic interaction	18191556	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	17588960	MGI
involved in cartilage homeostasis	IDA IDA: Inferred from direct assay	32747625	MGI
acts upstream of or within cellular senescence	IMP IMP: Inferred from mutant phenotype	27498005	MGI
acts upstream of or within chondrocyte development	IMP IMP: Inferred from mutant phenotype	17588960	MGI
acts upstream of or within chondrocyte proliferation	IGI IGI: Inferred from genetic interaction	18191556	MGI
acts upstream of or within chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	17588960	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	19808781	MGI
acts upstream of or within endochondral bone growth	IMP IMP: Inferred from mutant phenotype	20138147	MGI
acts upstream of or within growth plate cartilage development	IGI IGI: Inferred from genetic interaction	18191556	MGI
acts upstream of or within growth plate cartilage development	IMP IMP: Inferred from mutant phenotype	17588960	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	17588960	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	17588960	MGI
acts upstream of or within muscle cell development	IMP IMP: Inferred from mutant phenotype	19808781	MGI
acts upstream of or within musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	19808781	MGI
acts upstream of or within negative regulation of hemostasis	IMP IMP: Inferred from mutant phenotype	26045608	MGI
acts upstream of or within neuromuscular process	IMP IMP: Inferred from mutant phenotype	24312420	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	21350216	MGI
acts upstream of or within platelet aggregation	IMP IMP: Inferred from mutant phenotype	26045608	MGI
acts upstream of or within positive regulation of chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	17307734	MGI
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	32747625	MGI
acts upstream of or within protein processing	IMP IMP: Inferred from mutant phenotype	26045608	MGI
acts upstream of or within protein secretion	IMP IMP: Inferred from mutant phenotype	26746240	MGI
acts upstream of or within regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	21350216	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22006726	MGI
acts upstream of or within response to unfolded protein	IMP IMP: Inferred from mutant phenotype	17588960	MGI
acts upstream of or within skeletal system development	IGI IGI: Inferred from genetic interaction	18191556	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	26746240	MGI
acts upstream of or within tendon development	IMP IMP: Inferred from mutant phenotype	19808781	MGI
acts upstream of or within vascular associated smooth muscle cell development	IMP IMP: Inferred from mutant phenotype	21350216	MGI
acts upstream of or within vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	27498005	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	32747625	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	17588960	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	26045608	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cartilage oligomeric matrix protein

thrombospondin-5

Comp Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Comp	Q9R0G6	ADAMTS12	Homo sapiens	P58397	ELISA	16611630
Cross	Comp	Q9R0G6	ADAMTS12	Homo sapiens	P58397	Pull Down	16611630

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (41)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153991	STAT6-IN-2	Inhibitor	99.85%	Unkown
HY-160497	MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885		99.63%	Unkown
HY-138569	HPK1-IN-4	Inhibitor	99.42%	Unkown
HY-156592A	ROCK2-IN-6 hydrochloride	Inhibitor	99.95%	Unkown
HY-163573	FANCM-BTR PPI-IN-1		96.17%	Unkown
HY-125222	Drp1-IN-1	Inhibitor	98.02%	Unkown
HY-153413	Kras4B G12D-IN-1	Inhibitor	98.01%	Unkown
HY-153473	FLT3-IN-19	Inhibitor	99.19%	Unkown
HY-164788	GGFG-PAB-MMAE	Inhibitor	/	Unkown
HY-N12492	11,12-Di-O-methylcarnosol		/	Unkown
HY-136806	PI3K-IN-12	Inhibitor	/	Unkown
HY-138993	NNMT-IN-6	Inhibitor	/	Unkown
HY-139252	Anticancer agent 225	Inducer	/	Unkown
HY-139292	Fmoc-NH-PEG6-alcohol		/	Unkown
HY-139595	Polyketide synthase 13-IN-2	Inhibitor	/	Unkown
HY-145775	hIgG-hFc receptor-IN-1	Inhibitor	/	Unkown
HY-145865	c-Met/MEK1/Flt-3-IN-1	Inducer	/	Unkown
HY-145866	Antiproliferative agent-3	Inhibitor	/	Unkown
HY-145888	Antioxidant agent-2	Inhibitor	/	Unkown
HY-145896	Anti-osteoporosis agent-1	Inhibitor	/	Unkown
HY-149891	HSP90-IN-23	Inhibitor	/	Unkown
HY-150268	BET-IN-16	Inhibitor	/	Unkown
HY-153002	p38α inhibitor 3	Inhibitor	99.82%	Unkown
HY-153277	Axl/Mer/CSF1R-IN-2	Inhibitor	/	Unkown
HY-153739	N3-PEG3-VC-PAB-MMAF		/	Unkown
HY-153914	B-Raf IN 14	Inhibitor	/	Unkown
HY-153930	h15-LOX-2 inhibitor 1	Inhibitor	/	Unkown
HY-153989	SOS1-IN-16	Inhibitor	/	Unkown
HY-155610	VEGFR-2-IN-32	Inhibitor	/	Unkown
HY-156566	PROTAC BRD4 Degrader-21	Inhibitor	/	Unkown
HY-156592	ROCK2-IN-6	Inhibitor	/	Unkown
HY-156670	Camptothecin analog-1		/	Unkown
HY-156875	20-HETE inhibitor-1	Inhibitor	/	Unkown
HY-158326	FAP-IN-4	Inhibitor	/	Unkown
HY-160545	NLRP3-IN-31	Inhibitor	/	Unkown
HY-163569	FGFR4-IN-20	Inhibitor	/	Unkown
HY-164560	MALT1-IN-14	Inhibitor	/	Unkown
HY-P10723	IL-23R inhibitor peptide-1	Inhibitor	/	Unkown
HY-RS03015	COMP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119648A	(E/Z)-CCR-11	Inhibitor	98.00%	Unkown
HY-139223	pEBOV-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Comp	NCBI	NCBI:1311
Macaca fascicularis	Comp	NCBI	NCBI:101867220
Susscrofa domestica	Comp	NCBI
Rattus norvegicus	Comp	NCBI	NCBI:25304
Macaca mulatta	Comp	NCBI	NCBI:720286

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