Emd - emerin Gene

Mus musculus

Also known as Sta

Gene ID: 13726 | Gene type: protein coding

About Emd

Summary

This gene is the founding member of the LEM (Lap2beta, Emerin, and Man1) domain gene family. It encodes an integral membrane protein of the inner nuclear membrane. This gene may be involved in transcriptional regulation and genomic organization. In humans, mutations in this gene cause a class of diseases called laminopathies, which includes Emery-Dreifuss muscular dystrophy (EDMD). [provided by RefSeq, Apr 2013]

Emd Products(11)

mRNA	Protein	Name
NM_001410134.1	NP_001397063.1	emerin isoform 2
NM_001410135.1	NP_001397064.1	emerin isoform 2
NM_001410136.1	NP_001397065.1	emerin isoform 3
NM_001410137.1	NP_001397066.1	emerin isoform 4
NM_001410138.1	NP_001397067.1	emerin isoform 4
NM_001410139.1	NP_001397068.1	emerin isoform 4
NM_001410140.1	NP_001397069.1	emerin isoform 5
NM_001410141.1	NP_001397070.1	emerin isoform 6
NM_001410142.1	NP_001397071.1	emerin isoform 7
NM_001410143.1	NP_001397072.1	emerin isoform 8
NM_007927.4	NP_031953.1	emerin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19933576	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within skeletal muscle cell differentiation	IGI IGI: Inferred from genetic interaction	19720741	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	19720741	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in TMEM240-body	IDA IDA: Inferred from direct assay	32535204	MGI
located in nuclear envelope	IDA IDA: Inferred from direct assay	19933576	MGI
located in nuclear membrane	IDA IDA: Inferred from direct assay	17164264	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22349700	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

emerin

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14721	Tepotinib		99.94%	Yes
HY-14771A	Imeglimin hydrochloride		99.98%	Unkown
HY-14261	Vilazodone Hydrochloride		99.94%	Unkown
HY-14262	Vilazodone		99.84%	Unkown
HY-70057	Safinamide	Inhibitor	99.89%	Yes
HY-70057A	Safinamide mesylate	Inhibitor	99.87%	Yes
HY-14771	Imeglimin		/	Unkown

Clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16141	Cilengitide		99.80%	Phase 3
HY-100820	Sarizotan	Agonist	98.74%	Phase 3
HY-107384A	Asimadoline hydrochloride	Agonist	99.82%	Phase 3
HY-107384	Asimadoline	Agonist	99.36%	Phase 3
HY-100820B	Sarizotan dihydrochloride	Agonist	/	Phase 3
HY-106246	Pruvanserin	Antagonist	99.27%	Phase 2
HY-19273	Rimeporide	Inhibitor	98.71%	Phase 1
HY-15000	EMD534085	Inhibitor	99.55%	Phase 1
HY-103410	Carmoxirole hydrochloride	Agonist	99.82%	Phase 1
HY-106844	EMD 53998	Inhibitor	99.59%	Phase 1
HY-105112	Carmoxirole	Agonist	/	Phase 1
HY-123356	EMD-503982	Inhibitor	/	Phase 1
HY-19273A	Rimeporide hydrochloride	Inhibitor	/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9969	Matuzumab		98.12%	Phase 2
HY-P99183	Abituzumab	Inhibitor	99.38%	Phase 2

Pre-clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15193	EMD638683	Inhibitor	99.94%	Unkown
HY-16143	Cilengitide TFA		99.92%	Yes
HY-P0322	GRGDSPK	Inhibitor	98.12%	Unkown
HY-106150B	Eniporide hydrochloride	Inhibitor	98.97%	Unkown
HY-106844A	(+)-EMD 57033	Agonist	99.72%	Unkown
HY-101473	EMD527040	Inhibitor	99.94%	Unkown
HY-107030	Nitrefazole	Inhibitor	99.44%	Unkown
HY-106100A	Roxindole hydrochloride		99.53%	Unkown
HY-136280	Panamesine		99.43%	Unkown
HY-170410	EMD-95885	Antagonist	98.05%	Unkown
HY-15193B	EMD638683 S-Form	Inhibitor	99.95%	Unkown
HY-14203	(R)-Safinamide	Inhibitor	99.88%	Unkown
HY-19134	EMD 56551	Agonist	/	Unkown
HY-15193A	EMD638683 R-Form	Inhibitor	99.86%	Unkown
HY-14721A	Tepotinib hydrochloride		/	Unkown
HY-103115	Pruvanserin hydrochloride	Antagonist	/	Unkown
HY-103130	EMD386088	Agonist	99.06%	Unkown
HY-103247	EMD 66684	Antagonist	/	Unkown
HY-103247B	EMD-66684 potassium salt	Antagonist	/	Unkown
HY-106100	Roxindole		/	Unkown
HY-106150	Eniporide	Inhibitor	/	Unkown
HY-10777	EMD 495235	Inhibitor	/	Unkown
HY-114987	EMD 21657	Modulator	/	Unkown
HY-114990	EMD 57439	Inhibitor	/	Unkown
HY-14262S1	Vilazodone-d8 hydrochloride		/	Unkown
HY-169827	EMD-132338	Antagonist	/	Unkown
HY-70057S1	Safinamide-d4-1	Inhibitor	/	Unkown
HY-A0300	Cyclopeptide-5	Antagonist	/	Unkown
HY-P0322A	GRGDSPK TFA	Inhibitor	/	Unkown
HY-P2075	EMD 55068	Antagonist	/	Unkown
HY-RS04345	EMD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-100820A	Sarizotan hydrochloride	Agonist	/	Unkown
HY-106472	Tioxaprofen	Inhibitor	/	Unkown
HY-129714	EMD 52297	Inhibitor	/	Unkown
HY-164394	EMD 1204831	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Emd	NCBI	NCBI:2010
Macaca fascicularis	Emd	NCBI	NCBI:102138141

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