2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Mitochondrial Metabolism Reactive Oxygen Species
  4. Imeglimin hydrochloride

Imeglimin hydrochloride  (Synonyms: EMD 387008 hydrochloride)

Cat. No.: HY-14771A Purity: 99.98%
SDS COA Handling Instructions

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Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.

For research use only. We do not sell to patients.

Imeglimin hydrochloride Chemical Structure

Imeglimin hydrochloride Chemical Structure

CAS No. : 775351-61-6

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10 mM * 1 mL in DMSO
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Based on 3 publication(s) in Google Scholar

Other Forms of Imeglimin hydrochloride:

Imeglimin hydrochloride Related Antibodies

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  • Purity & Documentation

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Description

Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].

IC50 & Target

ROS; mitochondrial function[1]
In Vitro

Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Imeglimin hydrochloride Related Antibodies

Cell Viability Assay[2]

Cell Line: Human endothelial cells (HMEC-1)
Concentration: 100 μM and10 mM
Incubation Time: 100 μM for 24 h, 10 mM for 4 h
Result: Prevention of cell death.
In Vivo

Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6JOlaHsd mice (4 weeks old)[1]
Dosage: 200 mg/kg
Administration: Oral gavage; b.i.d.; 6 weeks
Result: A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
Clinical Trial
Molecular Weight

191.66

Formula

C6H14ClN5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.NC1=N[C@@H](C)N=C(N(C)C)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (260.88 mM)

DMSO : 25 mg/mL (130.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2175 mL 26.0876 mL 52.1752 mL
5 mM 1.0435 mL 5.2175 mL 10.4350 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (10.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (10.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (521.75 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.98%

SDS (393 KB)

COA (248 KB) HNMR (237 KB) RP-HPLC (245 KB) MS (178 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.2175 mL 26.0876 mL 52.1752 mL 130.4381 mL
5 mM 1.0435 mL 5.2175 mL 10.4350 mL 26.0876 mL
10 mM 0.5218 mL 2.6088 mL 5.2175 mL 13.0438 mL
15 mM 0.3478 mL 1.7392 mL 3.4783 mL 8.6959 mL
20 mM 0.2609 mL 1.3044 mL 2.6088 mL 6.5219 mL
25 mM 0.2087 mL 1.0435 mL 2.0870 mL 5.2175 mL
30 mM 0.1739 mL 0.8696 mL 1.7392 mL 4.3479 mL
40 mM 0.1304 mL 0.6522 mL 1.3044 mL 3.2610 mL
50 mM 0.1044 mL 0.5218 mL 1.0435 mL 2.6088 mL
60 mM 0.0870 mL 0.4348 mL 0.8696 mL 2.1740 mL
80 mM 0.0652 mL 0.3261 mL 0.6522 mL 1.6305 mL
100 mM 0.0522 mL 0.2609 mL 0.5218 mL 1.3044 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Imeglimin hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imeglimin775351-61-6EMD 387008EMD387008EMD-387008Mitochondrial MetabolismReactive Oxygen SpeciesoralglucoseloweringinsulinsensitivityROSmitochondrialfunctionInhibitorinhibitorinhibit

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