2. Gene
  3. Hp - haptoglobin Gene

Hp - haptoglobin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HP-1; preHP2

Gene ID: 15439 | Gene type: protein coding

About Hp

Summary

This gene encodes a plasma glycoprotein called haptoglobin that binds free hemoglobin. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta subunits that form a disulfide-linked tetrameric protein that plays an important role in the sequestration and clearance of extracorpuscular hemoglobin. Mice lacking the encoded protein exhibit stunted development of lymphoid organs associated with lower counts of mature T and B cells in the blood and secondary lymphoid compartments. [provided by RefSeq, Aug 2016]

Hp Products(2)

mRNA Protein Name
NM_001329965.1 NP_001316894.1 haptoglobin isoform 2 precursor
NM_017370.2 NP_059066.1 haptoglobin isoform 1 preproprotein
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
23117660 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

haptoglobin

zonulin

Related Agents

Approval
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101588 Gefapixant Antagonist 99.33% Unkown
HY-17410 Iloperidone Antagonist 99.97% Unkown
HY-101588A Gefapixant citrate Antagonist 99.23% Unkown
HY-B0933A Gadoteridol pentahydrate / Unkown
HY-17410A Iloperidone hydrochloride Antagonist / Unkown
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-101103 HP-β-CD 99.74% Phase 3
HY-127165 Velnacrine Inhibitor / Phase 3
HY-123857 JNJ-55308942 Antagonist 99.92% Phase 2
HY-117508 JNJ-54175446 Antagonist 99.30% Phase 2
Pre-clinical Phase
Bioactive Molecules (45)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114364 UDP-Galactose disodium Agonist 99.42% Unkown
HY-136026 Camlipixant Antagonist 99.94% Unkown
HY-15568 A-317491 Antagonist 98.77% Unkown
HY-151480 HP590 98.59% Unkown
HY-110329 ML179 Agonist 99.83% Unkown
HY-15568A A-317491 sodium salt hydrate Antagonist 99.88% Unkown
HY-154840 4-Thiouridine 5′-triphosphate tetralithium Agonist 87.53% Unkown
HY-146564A HP210 Modulator 98.96% Unkown
HY-P1397A RVD-Hpα TFA Agonist 99.32% Unkown
HY-W011246 Velnacrine maleate Inhibitor ≥98.0% Unkown
HY-W050088 Isoxepac 99.92% Unkown
HY-146564 R-HP210 98.21% Unkown
HY-E70058 α-1-3,4 Fucosyltransferase, helicobacter pylori 90.00% Unkown
HY-127165S2 Velnacrine-d4 hydrochloride 98.60% Unkown
HY-127165S Velnacrine-d3 / Unkown
HY-17410S Iloperidone-d3 Antagonist / Unkown
HY-106508 Fendosal Inhibitor / Unkown
HY-127165S1 Velnacrine-d3 maleate / Unkown
HY-127165S3 Velnacrine-d4 / Unkown
HY-136092 Androsta-1,4,6-triene-3,17-dione Inhibitor / Unkown
HY-143576 P2X3 antagonist 37 Antagonist / Unkown
HY-145690 HP1328 Inhibitor / Unkown
HY-145691 HP1142 Inhibitor / Unkown
HY-146561 S-HP210 Modulator 98.12% Unkown
HY-150524 UDP-Galactose Agonist / Unkown
HY-153710 P2X3 antagonist 38 Antagonist / Unkown
HY-15376 Besipirdine Antagonist / Unkown
HY-154840A 4-Thiouridine 5′-triphosphate tetrasodium Agonist / Unkown
HY-167855 MRS4833 Antagonist / Unkown
HY-170598 HP211206 Inhibitor / Unkown
HY-172200 PD-L1/HDAC6-IN-1 Inhibitor / Unkown
HY-17410S1 Iloperidone-d3 hydrochloride Antagonist / Unkown
HY-P10539 Hp1404 Inhibitor / Unkown
HY-P1397 RVD-Hpα Agonist / Unkown
HY-RS06331 HP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06332 HP1BP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W050088S Isoxepac-d6 / Unkown
HY-105463 Saptomycin D Inhibitor / Unkown
HY-106016 HP 184 Activator / Unkown
HY-14607 Besipirdine hydrochloride Inhibitor / Unkown
HY-168117 HP-101 Inhibitor / Unkown
HY-170599 H117 Inhibitor 99.27% Unkown
HY-170600 Boc-Ala(Me)-H117 / Unkown
HY-W097612 P2X4 antagonist-5 Control / Unkown
HY-108668 TC-P 262 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hp NCBI NCBI:3240
Canis familiaris Hp NCBI
Felis catus Hp NCBI NCBI:100144610
Macaca fascicularis Hp NCBI
Susscrofa domestica Hp NCBI
Rattus norvegicus Hp NCBI NCBI:24464
Macaca mulatta Hp NCBI NCBI:706640