2. Gene
  3. TMEM65 - transmembrane protein 65 Gene

TMEM65 - transmembrane protein 65 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 157378 | Gene type: protein coding

About TMEM65

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:124,306,189-124,372,701 (from NCBI)

This gene has 7 transcripts (splice variants) and 243 orthologues. Ubiquitous expression in duodenum (RPKM 11.1), brain (RPKM 8.4) and 25 other tissues.

Summary

Predicted to be involved in cardiac ventricle development and regulation of cardiac conduction. Located in intercalated disc; mitochondrial inner membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM65 Products(1)

mRNA Protein Name
NM_194291.3 NP_919267.2 transmembrane protein 65
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in intercalated disc IDA
IDA: Inferred from direct assay
26403541 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
24765583 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
26403541 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM65 Protein Structure

TMEM65

TMEM65: Transmembrane protein 65 (120 - 227)

  • 0
  • 100
  • 200
  • 240 a.a.
Protein Preferred Names Protein Names

transmembrane protein 65

TMEM65 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TMEM65 Q6PI78 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
TMEM65 Q6PI78 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 JAGN1 Homo sapiens Q8N5M9
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
TMEM65 Q6PI78 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 HSD17B11 Homo sapiens Q8NBQ5
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
Intra
TMEM65 Q6PI78 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 PTGES Homo sapiens O14684
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 PTGES Homo sapiens O14684
Y2H Array
32296183
Intra
TMEM65 Q6PI78 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
TMEM65 Q6PI78 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
TMEM65 Q6PI78 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TMEM65 Q6PI78 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra
TMEM65 Q6PI78 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
TMEM65 Q6PI78 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
TMEM65 Q6PI78 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 IGSF9 Homo sapiens Q9P2J2-2
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 IGSF9 Homo sapiens Q9P2J2-2
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 IGSF9 Homo sapiens Q9P2J2-2
Y2H Array
32296183
Intra
TMEM65 Q6PI78 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
TMEM65 Q6PI78 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 IL3RA Homo sapiens P26951
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 IL3RA Homo sapiens P26951
Y2H Array
32296183
Intra
TMEM65 Q6PI78 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
TMEM65 Q6PI78 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
TMEM65 Q6PI78 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
TMEM65 Q6PI78 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
TMEM65 Q6PI78 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 FAM174A Homo sapiens Q8TBP5
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra
TMEM65 Q6PI78 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 ABHD16A Homo sapiens O95870
Y2H Array
32296183
Intra
TMEM65 Q6PI78 ZFYVE27 Homo sapiens Q5T4F4
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 ZFYVE27 Homo sapiens Q5T4F4
Y2H Array
32296183
Intra
TMEM65 Q6PI78 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
TMEM65 Q6PI78 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
TMEM65 Q6PI78 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 TMEM101 Homo sapiens Q96IK0
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 TMEM101 Homo sapiens Q96IK0
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 TMEM101 Homo sapiens Q96IK0
Y2H Array
32296183
Intra
TMEM65 Q6PI78 JPH1 Homo sapiens Q9HDC5
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 JPH1 Homo sapiens Q9HDC5
Y2H Array
32296183
Intra
TMEM65 Q6PI78 JPH1 Homo sapiens Q9HDC5
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra
TMEM65 Q6PI78 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
TMEM65 Q6PI78 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
TMEM65 Q6PI78 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
TMEM65 Q6PI78 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
TMEM65 Q6PI78 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra
TMEM65 Q6PI78 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra
TMEM65 Q6PI78 MSMO1 Homo sapiens Q15800
Y2H Prey Pooling
32296183
Intra
TMEM65 Q6PI78 MSMO1 Homo sapiens Q15800
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mitochondrial Complex Iv Deficiency, Nuclear Type 5

Leigh Syndrome, French Canadian Type

Mitochondrial Complex V Deficiency Nuclear Type 4

Cytochrome C Oxidase Deficiency, French Canadian Type

Lsfc

Cox Deficiency, French Canadian Type

MC5DN4

MC4DN5

Cox Deficiency, Saguenay-Lac-Saint-Jean Type

Leigh Syndrome, Saguenay-Lac-Saint-Jean Type

Mitochondrial Complex V Deficiency, Nuclear Type 4

French Canadian Leigh Disease

Leigh Syndrome, French-Canadian Type

Leigh Syndrome , French Canadian Type

Mitochondrial Complex V Deficiency, Atp5a1 Type

French Canadian Type Cox Deficiency

French Canadian Type Cytochrome C Oxidase Deficiency

French Canadian Type Leigh Syndrome

Saguenay Lac Saint Jean Type Cox Deficiency

Saguenay Lac Saint Jean Type Leigh Syndrome

Cox Deficiency, Saguenay Lac Saint Jean Type

Leigh Syndrome, Saguenay Lac Saint Jean Type

Mitochondrial Complex V Deficiency, Nuclear Type 4

Mitochondrial Complex V Deficiency Atp5a1 Type

Mitochondrial Complex V Deficiency Type 4

Mitochondrial Complex V Deficiency, Nuclear, Type 4
Progressive Familial Heart Block

Hereditary Bundle Branch Defect

Hereditary Bundle Branch System Defect

Familial Lenegre Disease

Familial Lev Disease

Familial Lev-Lenegre Disease

Familial Pccd

Familial Progressive Heart Block

Pfhb

Bundle Branch Block

Hbbd

Lenegre Lev Disease

Lev Syndrome

Lev'S Disease

Lev-Lenègre Disease

Pccd

Progressive Cardiac Conduction Defect

Bundle-Branch Block
Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14736 TMEM65 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TMEM65 VGNC VGNC:47598
Bos taurus TMEM65 VGNC VGNC:36106
Macaca mulatta TMEM65 VGNC VGNC:104502
Rattus norvegicus TMEM65 RGD RGD:1563224
Mus musculus TMEM65 MGD MGI:1922118