2. Gene
  3. RBM17 - RNA binding motif protein 17 Gene

RBM17 - RNA binding motif protein 17 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SPF45

Gene ID: 84991 | Gene type: protein coding

About RBM17

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:6,089,034-6,117,447 (from NCBI)

This gene has 12 transcripts (splice variants) and 225 orthologues. Ubiquitous expression in bone marrow (RPKM 17.7), lymph node (RPKM 15.8) and 25 other tissues.

Summary

This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]

RBM17 Products(2)

mRNA Protein Name
NM_001145547.2 NP_001139019.1 splicing factor 45
NM_032905.5 NP_116294.1 splicing factor 45
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
17589525 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM17 Protein Structure

G-patch

G-patch: G-patch domain (238 - 276)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (328 - 386)

  • 0
  • 100
  • 200
  • 300
  • 401 a.a.
Protein Preferred Names Protein Names

splicing factor 45

45 kDa-splicing factor

RBM17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RBM17 Q96I25 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra RBM17 Q96I25 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra RBM17 Q96I25 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
Intra RBM17 Q96I25 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
Intra RBM17 Q96I25 PPP1R12C Homo sapiens Q9BZL4-5
Y2H Prey Pooling
25416956
Intra RBM17 Q96I25 PPP1R12C Homo sapiens Q9BZL4-5
Y2H Array
25416956
Intra RBM17 Q96I25 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra RBM17 Q96I25 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra RBM17 Q96I25 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra RBM17 Q96I25 SF1 Homo sapiens Q15637-4
Y2H Array
32296183
Intra RBM17 Q96I25 SF1 Homo sapiens Q15637-4
Y2H Prey Pooling
32296183
Intra RBM17 Q96I25 DHX15 Homo sapiens O43143
Anti Tag CoIP
35271311
Intra RBM17 Q96I25 DHX15 Homo sapiens O43143
Validated Y2H
25416956
Intra RBM17 Q96I25 DHX15 Homo sapiens O43143
Y2H Array
25416956
Intra RBM17 Q96I25 SF3B1 Homo sapiens O75533-1
X-Ray Diffraction
17589525
Intra RBM17 Q96I25 SF3B1 Homo sapiens O75533-1
Pull Down
17589525
Intra RBM17 Q96I25 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Intra RBM17 Q96I25 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
33961781
Intra RBM17 Q96I25 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
28514442
Intra RBM17 Q96I25 SUGP1 Homo sapiens Q8IWZ8
Anti Tag CoIP
35271311
Intra RBM17 Q96I25 QRICH1 Homo sapiens Q2TAL8
Validated Y2H
25416956
Intra RBM17 Q96I25 QRICH1 Homo sapiens Q2TAL8
Y2H Prey Pooling
25416956
Intra RBM17 Q96I25 CCDC170 Homo sapiens Q8IYT3
Y2H Array
32296183
Intra RBM17 Q96I25 CCDC170 Homo sapiens Q8IYT3
Y2H Prey Pooling
32296183
Intra RBM17 Q96I25 U2SURP Homo sapiens O15042
Anti Tag CoIP
33961781
Intra RBM17 Q96I25 U2SURP Homo sapiens O15042
Anti Tag CoIP
35271311
Intra RBM17 Q96I25 U2SURP Homo sapiens O15042
Y2H
22365833
Intra RBM17 Q96I25 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra RBM17 Q96I25 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra RBM17 Q96I25 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra RBM17 Q96I25 SAT1 Homo sapiens P21673
Y2H
21516116
Intra RBM17 Q96I25 SAT1 Homo sapiens P21673
Validated Y2H
25416956
Intra RBM17 Q96I25 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra RBM17 Q96I25 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra RBM17 Q96I25 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra RBM17 Q96I25 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra RBM17 Q96I25 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra RBM17 Q96I25 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra RBM17 Q96I25 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra RBM17 Q96I25 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra RBM17 Q96I25 PPP1R12C Homo sapiens Q9BZL4
Y2H Prey Pooling
32296183
Intra RBM17 Q96I25 PPP1R12C Homo sapiens Q9BZL4
Validated Y2H
32296183
Intra RBM17 Q96I25 PPP1R12C Homo sapiens Q9BZL4
Y2H Array
32296183
Intra RBM17 Q96I25 U2AF2 Homo sapiens P26368
Pull Down
17589525
Intra RBM17 Q96I25 SF1 Homo sapiens Q15637
Y2H Fragment Pooling
26420826
Intra RBM17 Q96I25 SF1 Homo sapiens Q15637
Pull Down
17589525
Intra RBM17 Q96I25 IQCN Homo sapiens Q9H0B3
Y2H Prey Pooling
25416956
Intra RBM17 Q96I25 IQCN Homo sapiens Q9H0B3
Y2H Array
25416956
Intra RBM17 Q96I25 CEP55 Homo sapiens Q53EZ4
Y2H Array
32296183
Intra RBM17 Q96I25 CEP55 Homo sapiens Q53EZ4
Y2H Array
31515488
Intra RBM17 Q96I25 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
32296183
Intra RBM17 Q96I25 SF3B1 Homo sapiens O75533
Anti Tag CoIP
33961781
Intra RBM17 Q96I25 SF3B1 Homo sapiens O75533
Anti Tag CoIP
28514442
Intra RBM17 Q96I25 SF3B1 Homo sapiens O75533
Anti Tag CoIP
35271311
Intra RBM17 Q96I25 SF3B1 Homo sapiens O75533
Phage Display
37219487
Intra RBM17 Q96I25 SF3B1 Homo sapiens O75533
Anti Tag CoIP
22365833
Intra RBM17 Q96I25 SF3B1 Homo sapiens O75533
Y2H
22365833
Intra RBM17 Q96I25 ATXN1 Homo sapiens P54253
Anti Tag CoIP
18337722
Intra RBM17 Q96I25 ATXN1 Homo sapiens P54253
Y2H
18337722
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sickle Cell Anemia

Hemoglobin Sc Disease

Anemia, Sickle Cell

Hbsc Disease

Sickle Cell-Hemoglobin C Disease Syndrome

Hb Ss Disease

Sickle Cell Trait

Drepanocytosis

Haemoglobin Sc Disease

Hb Sc Disease

Hb-S/Hb-C Disease

Hb-Ss Disease Without Crisis

Hemoglobin S Disease Without Crisis

Sickle Cell Anaemia

Sickle-Cell/Hb-C Disease Without Crisis

Sickle Cell - Hemoglobin C Disease

Hbs Disease

Hemoglobin S Disease

Sickling Disorder Due To Hemoglobin S

SKCA

Sickle Cell Disease

Sickle Cell-Hemoglobin C Disease

Sickle-Cell Disease Carrier

Sickle-Cell Heterozygous Disorder

Haemoglobin A-S Genotype

Hb-S - [Sickle Cell Haemoglobin] Carrier

Sickle Cell Haemoglobin Trait

As - [Sickle Cell Trait]

Hbas - [Sickle Cell Haemoglobin Trait]

Sickle-Cell Trait Haemoglobin Disease

Haemoglobin Sickle Cell Trait Disorder

Heterozygous Sickle Cell Trait

Hbas - [Heterozygous Haemoglobin S]
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11737 RBM17 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RBM17 VGNC VGNC:45411
Mus musculus RBM17 MGD MGI:1924188
Bos taurus RBM17 VGNC VGNC:33788
Macaca mulatta RBM17 VGNC VGNC:76496
Rattus norvegicus RBM17 RGD RGD:1311208
Felis catus RBM17 VGNC VGNC:64522