2. Gene
  3. ZGPAT - zinc finger CCCH-type and G-patch domain containing Gene

ZGPAT - zinc finger CCCH-type and G-patch domain containing Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847

Gene ID: 84619 | Gene type: protein coding

About ZGPAT

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,707,442-63,736,142 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 22.1), kidney (RPKM 17.5) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZGPAT Products(5)

mRNA Protein Name
NM_001083113.2 NP_001076582.1 zinc finger CCCH-type with G patch domain-containing protein isoform c
NM_001195653.2 NP_001182582.1 zinc finger CCCH-type with G patch domain-containing protein isoform c
NM_001195654.2 NP_001182583.1 zinc finger CCCH-type with G patch domain-containing protein isoform d
NM_032527.5 NP_115916.3 zinc finger CCCH-type with G patch domain-containing protein isoform a
NM_181485.3 NP_852150.2 zinc finger CCCH-type with G patch domain-containing protein isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19644445 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19644445 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19644445 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19644445 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19644445 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19644445 GOA
involved in negative regulation of epidermal growth factor-activated receptor activity IDA
IDA: Inferred from direct assay
19644445 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19644445 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
19644445 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZGPAT Protein Structure

G-patch

G-patch: G-patch domain (333 - 374)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 531 a.a.
Protein Preferred Names Protein Names

zinc finger CCCH-type with G patch domain-containing protein

g patch domain-containing protein 6

ZGPAT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ZGPAT Q8N5A5 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 MID2 Homo sapiens Q9UJV3-2
Y2H Array
25416956
Intra ZGPAT Q8N5A5 TP53BP2 Homo sapiens Q13625-3
Y2H Array
25416956
Intra ZGPAT Q8N5A5 TP53BP2 Homo sapiens Q13625-3
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Array
25416956
Intra ZGPAT Q8N5A5 AMOTL2 Homo sapiens Q9Y2J4-4
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra ZGPAT Q8N5A5 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra ZGPAT Q8N5A5 DHX15 Homo sapiens O43143
Y2H Array
25416956
Intra ZGPAT Q8N5A5 DHX15 Homo sapiens O43143
Anti Tag CoIP
19644445
Intra ZGPAT Q8N5A5 DHX15 Homo sapiens O43143
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 DHX15 Homo sapiens O43143
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 KIFC3 Homo sapiens Q9BVG8
Y2H
21516116
Intra ZGPAT Q8N5A5 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
Intra ZGPAT Q8N5A5 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra ZGPAT Q8N5A5 SSX2IP Homo sapiens Q9Y2D8
Y2H
21516116
Intra ZGPAT Q8N5A5 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
Intra ZGPAT Q8N5A5 BLZF1 Homo sapiens Q9H2G9
Y2H Array
25416956
Intra ZGPAT Q8N5A5 MIPOL1 Homo sapiens Q8TD10
Y2H Array
25416956
Intra ZGPAT Q8N5A5 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 CCDC57 Homo sapiens Q2TAC2
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 PHC2 Homo sapiens Q8IXK0
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 PHC2 Homo sapiens Q8IXK0
Y2H Array
25416956
Intra ZGPAT Q8N5A5 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 TLE5 Homo sapiens Q08117
Y2H Array
25416956
Intra ZGPAT Q8N5A5 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra ZGPAT Q8N5A5 BEND5 Homo sapiens Q7L4P6
Y2H Array
25416956
Intra ZGPAT Q8N5A5 BEND5 Homo sapiens Q7L4P6
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra ZGPAT Q8N5A5 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 DYDC1 Homo sapiens Q8WWB3
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 DYDC1 Homo sapiens Q8WWB3
Y2H Array
25416956
Intra ZGPAT Q8N5A5 DYDC1 Homo sapiens Q8WWB3
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 LDOC1 Homo sapiens O95751
Y2H Array
31515488
Intra ZGPAT Q8N5A5 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 ZBTB8A Homo sapiens Q96BR9
Y2H Array
25416956
Intra ZGPAT Q8N5A5 AIMP2 Homo sapiens Q13155
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 AIMP2 Homo sapiens Q13155
Y2H Array
25416956
Intra ZGPAT Q8N5A5 AIMP2 Homo sapiens Q13155
Validated Y2H
25416956
Intra ZGPAT Q8N5A5 STAC3 Homo sapiens Q96MF2
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 IKZF3 Homo sapiens Q9UKT9
Y2H Array
25416956
Intra ZGPAT Q8N5A5 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
25416956
Intra ZGPAT Q8N5A5 CCNDBP1 Homo sapiens O95273
Y2H
21516116
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Melnick-Needles Syndrome

MNS

Melnick-Needles Osteodysplasty

Osteodysplasty Of Melnick And Needles

Osteochondrodysplasias
Otopalatodigital Syndrome Spectrum Disorder

Opd Spectrum Disorder

Opsd

Fronto-Otopalatodigital Osteodysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16066 ZGPAT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZGPAT MGD MGI:2449939
Macaca mulatta ZGPAT VGNC VGNC:98469
Canis familiaris ZGPAT VGNC VGNC:54747
Bos taurus ZGPAT VGNC VGNC:57036
Rattus norvegicus ZGPAT RGD RGD:1310801