Ldha - lactate dehydrogenase A Gene

Mus musculus

Also known as Ldh1; Ldhm; l7R2

Gene ID: 16828 | Gene type: protein coding

About Ldha

Summary

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the Lactate Dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]

Ldha Products(2)

mRNA	Protein	Name
NM_001136069.2	NP_001129541.2	L-lactate dehydrogenase A chain isoform 2
NM_010699.2	NP_034829.1	L-lactate dehydrogenase A chain isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-lactate dehydrogenase activity	IDA IDA: Inferred from direct assay	7323947	MGI
enables L-lactate dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	3796661	MGI
enables lactate dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	8224816	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12107167	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within glucose catabolic process to lactate via pyruvate	IMP IMP: Inferred from mutant phenotype	8224816	MGI
involved in pyruvate catabolic process	IDA IDA: Inferred from direct assay	21041631	MGI
involved in pyruvate catabolic process	IMP IMP: Inferred from mutant phenotype	8224816	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	17572440	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11980919	MGI
located in sperm fibrous sheath	IDA IDA: Inferred from direct assay	16687649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

L-lactate dehydrogenase A chain

LDH muscle subunit	LDH-M
M-LDH	lactate dehydrogenase 1, A chain
lactate dehydrogenase A4

Recombinant Ldha Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70259	LDHA Protein, Mouse (HEK293, His)	P06151 (M1-F332)	≥95%
HY-P73270	LDHA Protein, Mouse (His)	P06151 (M1-F332)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W013032A	Oxamic acid sodium		99.72%	Unkown
HY-100681	GSK2837808A	Inhibitor	≥99.0%	Unkown
HY-16214	FX-11		99.21%	Unkown
HY-100742A	(R)-GNE-140	Inhibitor	99.73%	Unkown
HY-W040118	Galloflavin	Inhibitor	99.36%	Unkown
HY-139319	LDHA-IN-3	Inhibitor	99.88%	Unkown
HY-18968	LDHA-IN-4	Inhibitor	98.06%	Unkown
HY-100742	GNE-140 racemate	Inhibitor	99.38%	Unkown
HY-111108	LDH-IN-1	Inhibitor	99.86%	Unkown
HY-124309	NHI-2	Inhibitor	99.30%	Unkown
HY-W013032	Oxamic acid		99.98%	Unkown
HY-156683	CHK-336	Inhibitor	98.05%	Unkown
HY-100742B	(S)-GNE-140	Inhibitor	99.07%	Unkown
HY-147361	LDCA		99.18%	Unkown
HY-152261	MS6105		/	Unkown
HY-115875	LDHA-IN-5	Inhibitor	/	Unkown
HY-146977	LDHA/PDKs-IN-1	Inhibitor	/	Unkown
HY-146978	LDHA/PDKs-IN-2	Inhibitor	/	Unkown
HY-162627	LDHA-IN-6	Inhibitor	/	Unkown
HY-162629	LDHA-IN-7	Inhibitor	/	Unkown
HY-169060	LDHA-IN-8	Inhibitor	/	Unkown
HY-RS07571	LDHA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ldha	NCBI	NCBI:3939
Rattus norvegicus	Ldha	NCBI	NCBI:24533

Name
Email *

	Sorry, but the email address you supplied was invalid.