LDHA - Ldha lactate dehydrogenase A Gene

Rattus norvegicus

Also known as CDK1; Ldh1

Gene ID: 24533 | Gene type: protein coding

About LDHA

Summary

Enables several functions, including L-lactate dehydrogenase activity; NAD binding activity; and identical protein binding activity. Involved in several processes, including response to cAMP; response to estrogen; and response to glucose. Predicted to be located in cytosol and sperm fibrous sheath. Biomarker of hyperglycemia. Orthologous to human LDHA (Lactate Dehydrogenase A). [provided by Alliance of Genome Resources, Apr 2022]

LDHA Products(1)

mRNA	Protein	Name
NM_017025.2	NP_058721.1	L-lactate dehydrogenase A chain

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-lactate dehydrogenase activity	IDA IDA: Inferred from direct assay	17447164	RGD
enables NAD binding	IDA IDA: Inferred from direct assay	17447164	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	7138505	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	17572440	RGD
enables lactate dehydrogenase activity	IDA IDA: Inferred from direct assay	6849973	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7138505	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in NAD metabolic process	IDA IDA: Inferred from direct assay	17447164	RGD
involved in lactate metabolic process	IDA IDA: Inferred from direct assay	6849973	RGD
involved in liver development	IDA IDA: Inferred from direct assay	6849973	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9465046	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	6300127	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	17010207	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	11457846	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16154111	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	12678657	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15110778	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	7758843	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11176097	RGD
involved in skeletal muscle tissue development	IDA IDA: Inferred from direct assay	6849973	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

L-lactate dehydrogenase A chain

LDH muscle subunit	LDH-A
LDH-M

Recombinant LDHA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73271	LDHA Protein, Rat (His)	P04642 (M1-F332)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W013032A	Oxamic acid sodium		99.72%	Unkown
HY-100681	GSK2837808A	Inhibitor	≥99.0%	Unkown
HY-16214	FX-11		99.21%	Unkown
HY-100742A	(R)-GNE-140	Inhibitor	99.73%	Unkown
HY-W040118	Galloflavin	Inhibitor	99.36%	Unkown
HY-139319	LDHA-IN-3	Inhibitor	99.88%	Unkown
HY-18968	LDHA-IN-4	Inhibitor	98.06%	Unkown
HY-100742	GNE-140 racemate	Inhibitor	99.38%	Unkown
HY-111108	LDH-IN-1	Inhibitor	99.84%	Unkown
HY-W013032	Oxamic acid		99.98%	Unkown
HY-124309	NHI-2	Inhibitor	99.30%	Unkown
HY-100742B	(S)-GNE-140	Inhibitor	99.07%	Unkown
HY-147361	LDCA		99.18%	Unkown
HY-156683	CHK-336	Inhibitor	98.05%	Unkown
HY-152261	MS6105		99.2%	Unkown
HY-115875	LDHA-IN-5	Inhibitor	/	Unkown
HY-146977	LDHA/PDKs-IN-1	Inhibitor	/	Unkown
HY-146978	LDHA/PDKs-IN-2	Inhibitor	/	Unkown
HY-162627	LDHA-IN-6	Inhibitor	/	Unkown
HY-162629	LDHA-IN-7	Inhibitor	/	Unkown
HY-168733	LDHA-IN-9		/	Unkown
HY-169060	LDHA-IN-8	Inhibitor	/	Unkown
HY-RS07571	LDHA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	LDHA	NCBI	NCBI:3939
Mus musculus	LDHA	NCBI	NCBI:16828

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