2. Gene
  3. Cd40 - CD40 molecule Gene

Cd40 - CD40 molecule Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Tnfrsf5

Gene ID: 171369 | Gene type: protein coding

About Cd40

Summary

Enables antigen binding activity and protein domain specific binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to cobalamin; and response to interferon-gamma. Located in several cellular components, including cell surface; neuronal cell body; and varicosity. Used to study several diseases, including Ehrlich tumor carcinoma; artery disease (multiple); colitis; membranous glomerulonephritis; and obesity. Biomarker of asthma; atherosclerosis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd40 Products(1)

mRNA Protein Name
NM_134360.1 NP_599187.1 tumor necrosis factor receptor superfamily member 5 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables antigen binding IDA
IDA: Inferred from direct assay
22355605 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
25260678 RGD
Biological Process GO Annotation Evidence Reference Source
involved in B cell activation IMP
IMP: Inferred from mutant phenotype
27692815 RGD
involved in cellular response to erythropoietin IEP
IEP: Inferred from expression pattern
21649646 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
10403401 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19271152 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
10403401 RGD
involved in response to bacterium IEP
IEP: Inferred from expression pattern
22355605 RGD
involved in response to cobalamin IEP
IEP: Inferred from expression pattern
16716410 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
21840190 RGD
involved in response to peptide IEP
IEP: Inferred from expression pattern
19457161 RGD
involved in response to type II interferon IEP
IEP: Inferred from expression pattern
10403401 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
15069176 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16716410 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
25972624 RGD
located in varicosity IDA
IDA: Inferred from direct assay
25972624 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 5

CD40 antigen, TNF receptor superfamily member 5

CD40 molecule, TNF receptor superfamily member 5

tumor necrosis factor receptor superfamily, member 5

Recombinant Cd40 Proteins

Cat. No. Product Name Accession Purity
HY-P74295 CD40 Protein, Rat (HEK293, His) A6JXD6/NP_599187.1 (L20-R193) ≥95%
HY-P74296 CD40 Protein, Rat (HEK293, Fc) A6JXD6 (L20-R193) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-B1618 Corticosterone Agonist 99.76% Phase 3
HY-131968 BMS-986202 Inhibitor 99.92% Phase 1
Inhibitory Antibodies (10)
Cat. No. Product Name Effect
Purity Phase
HY-P99625 Frexalimab Inhibitor / Phase 3
HY-P99670 Iscalimab Inhibitor 99.25% Phase 2
HY-P99742 Mitazalimab Inhibitor 98.74% Phase 2
HY-P99167 Lucatumumab Inhibitor / Phase 2
HY-P99015 Dacetuzumab Inhibitor 95.37% Phase 2
HY-P99315 Ruplizumab Inhibitor 99.84% Phase 2
HY-P99701 Letolizumab Inhibitor 95.00% Phase 2
HY-P99821 Ravagalimab Inhibitor 99.31% Phase 2
HY-P99572 Tecaginlimab Inhibitor 99.00% Phase 2
HY-P99325 Toralizumab Inhibitor 95.00% Phase 1
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122663A BIO8898 Inhibitor 99.88% Unkown
HY-120323 DRI-C21045 Inhibitor 99.02% Unkown
HY-110247 TRAF-STOP inhibitor 6877002 Inhibitor 99.67% Unkown
HY-148980A Polyinosinic acid sodium / Unkown
HY-154821A DRI-C21041 (DIEA) Inhibitor / Unkown
HY-153345 Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br Agonist 99.67% Unkown
HY-122663 (Rac)-BIO8898 Inhibitor 99.81% Unkown
HY-16668 Tyrphostin A1 Inhibitor 98.96% Unkown
HY-152121 Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal Agonist 95.21% Unkown
HY-154822 DRI-C25441 Inhibitor 99.53% Unkown
HY-154821 DRI-C21041 Inhibitor / Unkown
HY-148980 Polyinosinic acid / Unkown
HY-125025 SMI 6860766 Inhibitor / Unkown
HY-143410 Anti-inflammatory agent 16 Inhibitor / Unkown
HY-148459 ATAC21 / Unkown
HY-D1124 Mordant brown 1 / Unkown
HY-P10399 KGYY15 Inhibitor / Unkown
HY-RS02246 CD40 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02247 CD40LG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-120471 AM-0687 Inhibitor / Unkown
HY-400878 Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal Agonist 99.86% Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99663 Inezetamab Inhibitor / Unkown
HY-P99842A Dapirolizumab Inhibitor 99.24% Unkown
HY-P99321 Teneliximab Inhibitor ≥99.0% Unkown
HY-P990111 BMS-986325 (anti-CD40) Inhibitor 96.46% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd40 NCBI NCBI:958
Canis familiaris Cd40 NCBI NCBI:403469
Macaca fascicularis Cd40 NCBI NCBI:102118696
Mus musculus Cd40 NCBI NCBI:21939
Leporidae Cd40 NCBI
Macaca mulatta Cd40 NCBI NCBI:707749