2. Gene
  3. Cd40 - CD40 antigen Gene

Cd40 - CD40 antigen Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5

Gene ID: 21939 | Gene type: protein coding

About Cd40

Summary

Predicted to enable antigen binding activity; protein domain specific binding activity; and ubiquitin protein Ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and cellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd40 Products(4)

mRNA Protein Name
NM_011611.2 NP_035741.2 tumor necrosis factor receptor superfamily member 5 isoform 1 precursor
NM_170702.2 NP_733803.2 tumor necrosis factor receptor superfamily member 5 isoform 5 precursor
NM_170703.2 NP_733804.1 tumor necrosis factor receptor superfamily member 5 isoform 2 precursor
NM_170704.2 NP_733805.1 tumor necrosis factor receptor superfamily member 5 isoform 4 precursor
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 5

B-cell surface antigen CD40

CD40L receptor

T-cell differentiation antigen

Recombinant Cd40 Proteins

Cat. No. Product Name Accession Purity
HY-P72724 CD40 Protein, Mouse (HEK293, His) P27512-1 (L20-R193) ≥95%
HY-P72911 CD40 Protein, Mouse (HEK293, Fc) P27512-1 (L20-R193) ≥95%
HY-P74298 CD40 Protein, Mouse (Biotinylated , HEK293, His-Avi) P27512-1/NP_035741.2 (L20-R193) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-B1618 Corticosterone Agonist 99.72% Phase 3
HY-131968 BMS-986202 Inhibitor 99.92% Phase 1
Inhibitory Antibodies (10)
Cat. No. Product Name Effect
Purity Phase
HY-P99625 Frexalimab Inhibitor / Phase 3
HY-P99670 Iscalimab Inhibitor 99.25% Phase 2
HY-P99167 Lucatumumab Inhibitor 98.18% Phase 2
HY-P99742 Mitazalimab Inhibitor 98.74% Phase 2
HY-P99015 Dacetuzumab Inhibitor 95.37% Phase 2
HY-P99315 Ruplizumab Inhibitor 99.84% Phase 2
HY-P99701 Letolizumab Inhibitor 95.00% Phase 2
HY-P99821 Ravagalimab Inhibitor 99.31% Phase 2
HY-P99572 Tecaginlimab Inhibitor 99.00% Phase 2
HY-P99325 Toralizumab Inhibitor 95.00% Phase 1
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122663A BIO8898 Inhibitor 99.88% Unkown
HY-120323 DRI-C21045 Inhibitor 99.02% Unkown
HY-110247 TRAF-STOP inhibitor 6877002 Inhibitor 99.67% Unkown
HY-148980A Polyinosinic acid sodium / Unkown
HY-153345 Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br Agonist 99.67% Unkown
HY-154821A DRI-C21041 (DIEA) Inhibitor / Unkown
HY-122663 (Rac)-BIO8898 Inhibitor 99.81% Unkown
HY-16668 Tyrphostin A1 Inhibitor 98.96% Unkown
HY-152121 Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal Agonist 95.21% Unkown
HY-154822 DRI-C25441 Inhibitor 99.53% Unkown
HY-154821 DRI-C21041 Inhibitor / Unkown
HY-148980 Polyinosinic acid / Unkown
HY-125025 SMI 6860766 Inhibitor / Unkown
HY-143410 Anti-inflammatory agent 16 Inhibitor / Unkown
HY-148459 ATAC21 / Unkown
HY-D1124 Mordant brown 1 / Unkown
HY-P10399 KGYY15 Inhibitor / Unkown
HY-RS02246 CD40 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS02247 CD40LG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-120471 AM-0687 Inhibitor / Unkown
HY-400878 Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal Agonist 99.86% Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99663 Inezetamab Inhibitor / Unkown
HY-P99321 Teneliximab Inhibitor ≥99.0% Unkown
HY-P990111 BMS-986325 (anti-CD40) Inhibitor 96.46% Unkown
HY-P99842A Dapirolizumab Inhibitor 99.24% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd40 NCBI NCBI:958
Canis familiaris Cd40 NCBI NCBI:403469
Macaca fascicularis Cd40 NCBI NCBI:102118696
Leporidae Cd40 NCBI
Rattus norvegicus Cd40 NCBI NCBI:171369
Macaca mulatta Cd40 NCBI NCBI:707749