Cd40 - CD40 antigen Gene

Mus musculus

Also known as IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5

Gene ID: 21939 | Gene type: protein coding

About Cd40

Summary

Predicted to enable antigen binding activity; protein domain specific binding activity; and ubiquitin protein Ligase binding activity. Involved in B cell mediated immunity; CD40 signaling pathway; and cellular calcium ion homeostasis. Acts upstream of or within several processes, including defense response to Other organism; positive regulation of B cell activation; and positive regulation of interleukin-12 production. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd40 Products(4)

mRNA	Protein	Name
NM_011611.2	NP_035741.2	tumor necrosis factor receptor superfamily member 5 isoform 1 precursor
NM_170702.2	NP_733803.2	tumor necrosis factor receptor superfamily member 5 isoform 5 precursor
NM_170703.2	NP_733804.1	tumor necrosis factor receptor superfamily member 5 isoform 2 precursor
NM_170704.2	NP_733805.1	tumor necrosis factor receptor superfamily member 5 isoform 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8910514	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell activation	IDA IDA: Inferred from direct assay	14594818	MGI
involved in B cell mediated immunity	IGI IGI: Inferred from genetic interaction	18624351	MGI
acts upstream of B cell proliferation	IDA IDA: Inferred from direct assay	8666928	MGI
acts upstream of B cell proliferation	IGI IGI: Inferred from genetic interaction	15963492	MGI
involved in CD40 signaling pathway	IGI IGI: Inferred from genetic interaction	18624351	MGI
acts upstream of or within defense response to protozoan	IDA IDA: Inferred from direct assay	19047410	MGI
acts upstream of or within defense response to virus	IDA IDA: Inferred from direct assay	17277142	MGI
acts upstream of or within immune response-regulating cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	15240714	MGI
involved in immunoglobulin production	IGI IGI: Inferred from genetic interaction	18624351	MGI
acts upstream of interleukin-12 production	IDA IDA: Inferred from direct assay	15240714	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	21410936	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	16546095	MGI
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	8666928	MGI
acts upstream of or within positive regulation of B cell proliferation	IGI IGI: Inferred from genetic interaction	15963492	MGI
acts upstream of or within positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	15240714	MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes	IDA IDA: Inferred from direct assay	12882831	MGI
acts upstream of or within regulation of immune response	IDA IDA: Inferred from direct assay	12882831	MGI
acts upstream of or within regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	12958312	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CD40 receptor complex	IDA IDA: Inferred from direct assay	20614026	MGI
located in cell surface	IDA IDA: Inferred from direct assay	20685650	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8566034	MGI
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	16708399	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	20614026	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 5

B-cell surface antigen CD40	CD40L receptor
T-cell differentiation antigen

Cd40 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cd40	P27512	Traf2	Mus musculus	P39429	Anti Bait CoIP	23334419
Intra	Cd40	P27512	Btk	Mus musculus	P35991	Confocal	21441935
Intra	Cd40	P27512	Btk	Mus musculus	P35991	Anti Tag CoIP	21441935

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Cd40 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72724	CD40 Protein, Mouse (HEK293, His)	P27512-1 (L20-R193)	≥95%
HY-P72911	CD40 Protein, Mouse (HEK293, Fc)	P27512-1 (L20-R193)	≥95%
HY-P74298	CD40 Protein, Mouse (Biotinylated , HEK293, His-Avi)	P27512-1/NP_035741.2 (L20-R193)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B1618	Corticosterone	Agonist	99.76%	Phase 3
HY-131968	BMS-986202	Inhibitor	99.92%	Phase 1

Inhibitory Antibodies (14)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99625	Frexalimab	Inhibitor	99.00%	Phase 3
HY-P99845	Dazodalibep		99.90%	Phase 3
HY-P99049	Sotigalimab	Agonist	98.90%	Phase 2
HY-P99670	Iscalimab	Inhibitor	99.64%	Phase 2
HY-P99742	Mitazalimab	Inhibitor	98.74%	Phase 2
HY-P99167	Lucatumumab	Inhibitor	98.18%	Phase 2
HY-P99015	Dacetuzumab	Inhibitor	95.37%	Phase 2
HY-P99257	Bleselumab	Inhibitor	98.97%	Phase 2
HY-P99315	Ruplizumab	Inhibitor	99.84%	Phase 2
HY-P99701	Letolizumab	Inhibitor	95.00%	Phase 2
HY-P990726	Abiprubart		99.00%	Phase 2
HY-P99821	Ravagalimab	Inhibitor	99.31%	Phase 2
HY-P99572	Tecaginlimab	Inhibitor	99.00%	Phase 2
HY-P99325	Toralizumab	Inhibitor	99.57%	Phase 1

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122663A	BIO8898	Inhibitor	99.88%	Unkown
HY-120323	DRI-C21045	Inhibitor	99.02%	Unkown
HY-110247	TRAF-STOP inhibitor 6877002	Inhibitor	99.67%	Unkown
HY-148980A	Polyinosinic acid sodium		/	Unkown
HY-154821A	DRI-C21041 (DIEA)	Inhibitor	/	Unkown
HY-153345	Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br	Agonist	99.67%	Unkown
HY-122663	(Rac)-BIO8898	Inhibitor	99.81%	Unkown
HY-154822	DRI-C25441	Inhibitor	99.53%	Unkown
HY-16668	Tyrphostin A1	Inhibitor	98.96%	Unkown
HY-152121	Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal	Agonist	95.21%	Unkown
HY-154821	DRI-C21041	Inhibitor	/	Unkown
HY-49382	Fluocinolone acetonide 3-benzylaniline		/	Unkown
HY-148980	Polyinosinic acid		/	Unkown
HY-125025	SMI 6860766	Inhibitor	/	Unkown
HY-143410	Anti-inflammatory agent 16	Inhibitor	/	Unkown
HY-148459	ATAC21		/	Unkown
HY-D1124	Mordant brown 1		/	Unkown
HY-P10399	KGYY15	Inhibitor	/	Unkown
HY-RS02246	CD40 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02247	CD40LG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-120471	AM-0687	Inhibitor	/	Unkown
HY-400878	Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal	Agonist	99.86%	Unkown

Inhibitory Antibodies (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99663	Inezetamab	Inhibitor	99.77%	Unkown
HY-P99842A	Dapirolizumab	Inhibitor	99.40%	Unkown
HY-P990083	Tegoprubart		99.20%	Unkown
HY-P99321	Teneliximab	Inhibitor	≥99.0%	Unkown
HY-P990111	BMS-986325 (anti-CD40)	Inhibitor	96.46%	Unkown
HY-P990134	Anti-Mouse CD40L/CD154 Antibody (MR-1)	Inhibitor	95.00%	Unkown
HY-P990270	Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd40	NCBI	NCBI:958
Canis familiaris	Cd40	NCBI	NCBI:403469
Macaca fascicularis	Cd40	NCBI	NCBI:102118696
Leporidae	Cd40	NCBI
Rattus norvegicus	Cd40	NCBI	NCBI:171369
Macaca mulatta	Cd40	NCBI	NCBI:707749

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