DUSP4 - dual specificity phosphatase 4 Gene

Homo sapiens

Also known as TYP; HVH2; MKP2; MKP-2

Gene ID: 1846 | Gene type: protein coding

About DUSP4

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:29,333,064-29,350,684 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 30 paralogues. Broad expression in stomach (RPKM 8.5), gall bladder (RPKM 5.0) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]

DUSP4 Products(2)

mRNA	Protein	Name
NM_001394.7	NP_001385.1	dual specificity protein phosphatase 4 isoform 1
NM_057158.4	NP_476499.1	dual specificity protein phosphatase 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	7535768	GOA
enables phosphatase activity	IDA IDA: Inferred from direct assay	24531476	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16038800	GOA
enables protein tyrosine phosphatase activity	IDA IDA: Inferred from direct assay	7535768	GOA
enables protein tyrosine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	7535768	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in dephosphorylation	IDA IDA: Inferred from direct assay	24531476	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	7535768	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	7535768	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP4 Protein Structure

Rhodanese

DSPc

0
100
200
300
394 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 4

MAP kinase phosphatase 2

DUSP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DUSP4	Q13115	LYSMD1	Homo sapiens	Q96S90	Validated Y2H	32296183
Intra	DUSP4	Q13115	LYSMD1	Homo sapiens	Q96S90	Y2H Array	32296183
Intra	DUSP4	Q13115	LYSMD1	Homo sapiens	Q96S90	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	DUSP4	Q13115	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	DUSP4	Q13115	NOXA1	Homo sapiens	Q86UR1-2	Validated Y2H	32296183
Intra	DUSP4	Q13115	LYSMD2	Homo sapiens	Q8IV50-2	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	LYSMD2	Homo sapiens	Q8IV50-2	Validated Y2H	32296183
Intra	DUSP4	Q13115	LYSMD2	Homo sapiens	Q8IV50-2	Y2H Array	32296183
Intra	DUSP4	Q13115	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	DUSP4	Q13115	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	DUSP4	Q13115	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	DUSP4	Q13115	MAPK9	Homo sapiens	P45984	PLA	25241761
Intra	DUSP4	Q13115	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	DUSP4	Q13115	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	DUSP4	Q13115	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	DUSP4	Q13115	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	DUSP4	Q13115	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	DUSP4	Q13115	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	DUSP4	Q13115	ZNF426	Homo sapiens	Q9BUY5	Validated Y2H	32296183
Intra	DUSP4	Q13115	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	32296183
Intra	DUSP4	Q13115	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	27880917
Intra	DUSP4	Q13115	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	16038800
Intra	DUSP4	Q13115	MAPK1	Homo sapiens	P28482	Y2H Prey Pooling	32296183
Intra	DUSP4	Q13115	MAPK1	Homo sapiens	P28482	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ogden Syndrome

OGDNS	N-Terminal Acetyltransferase Deficiency
NATD	N-Alpha-Acetyltransferase
X-Linked Malformation And Infantile Lethality Syndrome	Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04065	DUSP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DUSP4	VGNC	VGNC:61668
Rattus norvegicus	DUSP4	RGD	RGD:620625
Macaca mulatta	DUSP4	VGNC	VGNC:104448
Bos taurus	DUSP4	VGNC	VGNC:28260
Mus musculus	DUSP4	MGD	MGI:2442191

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