EEF1A1 - eukaryotic translation elongation factor 1 alpha 1 Gene

Homo sapiens

Also known as CCS3; EF1A; PTI1; CCS-3; EE1A1; EEF-1; EEF1A; EF-Tu; EF1A1; LENG7; eEF1A-1; GRAF-1EF; EF1alpha1

Gene ID: 1915 | Gene type: protein coding

About EEF1A1

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,515,750-73,521,032 (from NCBI)

This gene has 23 transcripts (splice variants), 236 orthologues and 18 paralogues. Ubiquitous expression in ovary (RPKM 2994.9), thyroid (RPKM 2551.7) and 25 other tissues.

Summary

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]

EEF1A1 Products(1)

mRNA	Protein	Name
NM_001402.6	NP_001393.1	elongation factor 1-alpha 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	26593721	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	18263879	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	26651998	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9852145	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17177976	GOA
enables tRNA binding	IDA IDA: Inferred from direct assay	12426392	GOA
enables translation elongation factor activity	IDA IDA: Inferred from direct assay	26593721	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	9852145	GOA
involved in positive regulation by host of viral genome replication	IDA IDA: Inferred from direct assay	33495306	GOA
involved in translational elongation	IDA IDA: Inferred from direct assay	26593721	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	19158340	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	8743958	GOA
located in cytosol	IDA IDA: Inferred from direct assay	19158340	GOA
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	36638793	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	9852145	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	12426392	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8743958	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26497934	GOA
is active in ribosome	IDA IDA: Inferred from direct assay	26651998	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	19158340	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF1A1 Protein Structure

GTP_EFTU

GTP_EFTU_D2

GTP_EFTU_D3

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

elongation factor 1-alpha 1

CTCL tumor antigen

Recombinant EEF1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72178	EEF1A1 Protein, Human (His-SUMO)	P68104 (M1-K462)	≥95%

Related Diseases

Diseases

Alias

Felty Syndrome

Felty'S Syndrome	Rheumatoid Arthritis With Splenoadenomegaly And Leukopenia
Familial Felty'S Syndrome	Rheumatoid Arthritis, Splenomegaly And Neutropenia
Splenomegaly-Neutropenia-Rheumatoid Arthritis Syndrome	Feltys Syndrome

Eukaryotic Translation Elongation Factor 1 Alpha-1-Like 14

EEF1A1L14	Prostatic Carcinoma Tumor-Inducing Gene 1
Pti1

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
X-Linked Intellectual Disability And Macroorchidism	Frax Syndrome
Symptomatic Form Of Fragile X Syndrome In Female Carriers	Fragile-X Syndrome
Fraxe Syndrome

Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome

ACOGS

Legionnaire Disease

Legionnaires' Disease	Legionnaires Disease
Legionnaire Disease, Susceptibility To	Legionella
Legionella Pneumonia	Infection By Legionella Pneumophilia
Legionnaire'S Disease	Legionellosis
Legionaire Disease, Susceptibility To	Legionnaires Pneumonia

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Legionellosis

Legionella Infection	Pontiac Fever
Legionnaires' Disease	Infection By Legionella Pneumophilia
Legionella Pneumophila Infection

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04174	EEF1A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-123035	Gamendazole	Inhibitor	/	Unkown
HY-P3818	PKCδ Peptide Substrate		/	Unkown
HY-RS04178	EEF1E1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EEF1A1	MGD	MGI:1096881
Rattus norvegicus	EEF1A1	RGD	RGD:67387
Macaca mulatta	EEF1A1	VGNC	VGNC:81065
Bos taurus	EEF1A1	VGNC	VGNC:56362
Others	EEF1A1	NCBI

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