2. Gene
  3. EIF4A2 - eukaryotic translation initiation factor 4A2 Gene

EIF4A2 - eukaryotic translation initiation factor 4A2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II

Gene ID: 1974 | Gene type: protein coding

About EIF4A2

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,783,577-186,789,897 (from NCBI)

This gene has 27 transcripts (splice variants), 230 orthologues, 38 paralogues and is associated with 54 phenotypes. Ubiquitous expression in ovary (RPKM 426.9), brain (RPKM 313.7) and 25 other tissues.

Summary

Enables ATP hydrolysis activity. Involved in negative regulation of RNA-directed 5'-3' RNA polymerase activity. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EIF4A2 Products(1)

mRNA Protein Name
NM_001967.4 NP_001958.2 eukaryotic initiation factor 4A-II
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
11922617 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11922617 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of RNA-dependent RNA polymerase activity IDA
IDA: Inferred from direct assay
11922617 GOA
Cellular Component GO Annotation Evidence Reference Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11922617 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF4A2 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (59 - 224)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (294 - 369)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
Protein Preferred Names Protein Names

eukaryotic initiation factor 4A-II

ATP-dependent RNA helicase eIF4A-2

Recombinant EIF4A2 Proteins

Cat. No. Product Name Accession Purity
HY-P700526 EIF4A2 Protein, Human (GST) Q14240 (M1-I407) ≥95%

Related Diseases

Diseases Alias
Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas
Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8

SCA8

Ataxia, Spinocerebellar, Type 8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145262 eIF4E-IN-2 Inhibitor 98.76% Unkown
HY-129768 CMLD012072 Inhibitor / Unkown
HY-RS04271 EIF4A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04275 EIF4E2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04278 EIF4EBP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04282 EIF4G2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EIF4A2 VGNC VGNC:84185
Canis familiaris EIF4A2 VGNC VGNC:40280
Mus musculus EIF4A2 MGD MGI:106906
Bos taurus EIF4A2 VGNC VGNC:28405
Felis catus EIF4A2 VGNC VGNC:61788
Rattus norvegicus EIF4A2 RGD RGD:1309225
Others EIF4A2 NCBI