Cxcl12 - chemokine (C-X-C motif) ligand 12 Gene

Mus musculus

Also known as Pbsf; Sdf1; Tlsf; Tpar1; Scyb12

Gene ID: 20315 | Gene type: protein coding

About Cxcl12

Summary

This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Cxcl12 Products(3)

mRNA	Protein	Name
NM_001012477.2	NP_001012495.1	stromal cell-derived factor 1 isoform gamma precursor
NM_013655.4	NP_038683.1	stromal cell-derived factor 1 isoform beta precursor
NM_021704.3	NP_068350.1	stromal cell-derived factor 1 isoform alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemokine activity	IDA IDA: Inferred from direct assay	12183377	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell proliferation	IMP IMP: Inferred from mutant phenotype	12707343	MGI
acts upstream of or within ameboidal-type cell migration	IMP IMP: Inferred from mutant phenotype	15626744	MGI
acts upstream of or within blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	15626744	MGI
acts upstream of or within brain development	IDA IDA: Inferred from direct assay	12183377	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15626744	MGI
acts upstream of or within cell-cell adhesion	IDA IDA: Inferred from direct assay	20847314	MGI
involved in dopaminergic neuron differentiation	IDA IDA: Inferred from direct assay	22535492	MGI
acts upstream of or within germ cell development	IDA IDA: Inferred from direct assay	12900445	MGI
acts upstream of or within germ cell migration	IDA IDA: Inferred from direct assay	12900445	MGI
acts upstream of or within induction of positive chemotaxis	IDA IDA: Inferred from direct assay	12900445	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	16129397	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	22956548	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	22956548	MGI
acts upstream of or within positive regulation of calcium ion import	IDA IDA: Inferred from direct assay	8962122	MGI
acts upstream of or within positive regulation of cell migration	IDA IDA: Inferred from direct assay	12900445	MGI
acts upstream of or within positive regulation of chemotaxis	IGI IGI: Inferred from genetic interaction	22956548	MGI
acts upstream of or within positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	23844157	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	22956548	MGI
acts upstream of or within regulation of cell migration	IDA IDA: Inferred from direct assay	12183377	MGI
acts upstream of or within regulation of cell migration	IGI IGI: Inferred from genetic interaction	19064997	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19008373	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

stromal cell-derived factor 1

12-O-tetradecanoylphorbol 13-acetate repressed protein 1	pre-B-cell growth-stimulating factor
thymic lymphoma cell-stimulating factor

Recombinant Cxcl12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7285	SDF-1 alpha/CXCL12 Protein, Mouse	P40224-1 (K22-K89)	≥95%
HY-P7403	SDF-1 alpha/CXCL12 Protein, Mouse (68a.a, CHO)	P40224-1 (K22-K89)	≥95%
HY-P72782	SDF-1 beta/CXCL12 Protein, Mouse	P40224-2 (K22-M93)	≥95%
HY-P700219AF	Animal-Free SDF-1 alpha/CXCL12 Protein, Mouse (His)	P40224 (G21-K89)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-114244	USL311	Antagonist	99.97%	Phase 2
HY-13696	MSX-122	Antagonist	98.92%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99272	Ulocuplumab	Antagonist	99.90%	Phase 3

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142617	ACT-1004-1239	Antagonist	99.80%	Yes
HY-110318	VUF11207 fumarate	Agonist	98.50%	Unkown
HY-101458A	IT1t dihydrochloride		99.77%	Unkown
HY-139643	CXCR7 antagonist-1	Antagonist	99.97%	Unkown
HY-15478	WZ811	Antagonist	99.79%	Unkown
HY-15971	AMD 3465 hexahydrobromide		≥98.0%	Unkown
HY-139643A	CXCR7 antagonist-1 hydrochloride	Antagonist	99.66%	Unkown
HY-P1103	CTCE-9908	Antagonist	99.69%	Unkown
HY-15971A	AMD 3465		99.59%	Unkown
HY-112709	LIT-927		99.86%	Unkown
HY-101458	IT1t		/	Unkown
HY-N3255	Minecoside	Inhibitor	99.86%	Unkown
HY-160041	Olaptesed pegol	Inhibitor	/	Unkown
HY-160041A	Olaptesed pegol sodium	Inhibitor	/	Unkown
HY-129094	ICT5040	Antagonist	/	Unkown
HY-131374	TN14003	Inhibitor	/	Unkown
HY-139906	CXCL12 ligand 1	Inhibitor	/	Unkown
HY-146372	CXCR4 antagonist 5	Antagonist	/	Unkown
HY-146401	CXCR4 antagonist 6	Antagonist	/	Unkown
HY-147978	CXCR4 antagonist 8	Antagonist	/	Unkown
HY-147979	CXCR4 antagonist 9	Antagonist	/	Unkown
HY-168095	CXCR4 antagonist 10	Inhibitor	/	Unkown
HY-P10415	EPI-X4	Antagonist	/	Unkown
HY-P1103A	CTCE-9908 TFA	Antagonist	/	Unkown
HY-RS03386	CXCL12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cxcl12	NCBI	NCBI:6387
Canis familiaris	Cxcl12	NCBI	NCBI:449622
Rattus norvegicus	Cxcl12	NCBI	NCBI:24772

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