2. Gene
  3. Cxcl12 - C-X-C motif chemokine ligand 12 Gene

Cxcl12 - C-X-C motif chemokine ligand 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Sdf1

Gene ID: 24772 | Gene type: protein coding

About Cxcl12

Summary

Predicted to enable CXCR Chemokine Receptor binding activity; chemokine activity; and Integrin binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of ion transport. Located in several cellular components, including extracellular space; nucleus; and plasma membrane. Used to study myocardial infarction. Biomarker of anti-basement membrane glomerulonephritis; brain ischemia; myocardial infarction; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12). [provided by Alliance of Genome Resources, Apr 2022]

Cxcl12 Products(3)

mRNA Protein Name
NM_001033882.1 NP_001029054.1 stromal cell-derived factor 1 isoform beta precursor
NM_001033883.1 NP_001029055.1 stromal cell-derived factor 1 isoform gamma precursor
NM_022177.3 NP_071513.1 stromal cell-derived factor 1 isoform alpha precursor
Protein Preferred Names Protein Names

stromal cell-derived factor 1

SDF-1 gamma

chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)

stromal cell-derived factor-1 gamma

Recombinant Cxcl12 Proteins

Cat. No. Product Name Accession Purity
HY-P7286 SDF-1 alpha/CXCL12 Protein, Rat Q9QZD1/Q80YV8 (K22-K89) ≥95%
HY-P72781 SDF-1 beta/CXCL12 Protein, Rat NP_001029054.1 (K22-M93) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-114244 USL311 Antagonist 99.97% Phase 2
HY-13696 MSX-122 Antagonist 98.92% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99272 Ulocuplumab Antagonist 99.90% Phase 3
Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-142617 ACT-1004-1239 Antagonist 99.80% Yes
HY-110318 VUF11207 fumarate Agonist 98.50% Unkown
HY-101458A IT1t dihydrochloride 99.77% Unkown
HY-139643 CXCR7 antagonist-1 Antagonist 99.97% Unkown
HY-15478 WZ811 Antagonist 99.79% Unkown
HY-15971 AMD 3465 hexahydrobromide ≥98.0% Unkown
HY-139643A CXCR7 antagonist-1 hydrochloride Antagonist 99.66% Unkown
HY-P1103 CTCE-9908 Antagonist 99.69% Unkown
HY-15971A AMD 3465 99.59% Unkown
HY-112709 LIT-927 99.86% Unkown
HY-101458 IT1t / Unkown
HY-N3255 Minecoside Inhibitor 99.86% Unkown
HY-160041 Olaptesed pegol Inhibitor / Unkown
HY-160041A Olaptesed pegol sodium Inhibitor / Unkown
HY-129094 ICT5040 Antagonist / Unkown
HY-131374 TN14003 Inhibitor / Unkown
HY-139906 CXCL12 ligand 1 Inhibitor / Unkown
HY-146372 CXCR4 antagonist 5 Antagonist / Unkown
HY-146401 CXCR4 antagonist 6 Antagonist / Unkown
HY-147978 CXCR4 antagonist 8 Antagonist / Unkown
HY-147979 CXCR4 antagonist 9 Antagonist / Unkown
HY-P10415 EPI-X4 Antagonist / Unkown
HY-P1103A CTCE-9908 TFA Antagonist / Unkown
HY-RS03386 CXCL12 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcl12 NCBI NCBI:6387
Canis familiaris Cxcl12 NCBI NCBI:449622
Mus musculus Cxcl12 NCBI NCBI:20315
Macaca mulatta Cxcl12 NCBI NCBI:574334