ERG - ETS transcription factor ERG Gene

Homo sapiens

Also known as p55; erg-3

Gene ID: 2078 | Gene type: protein coding

About ERG

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:38,367,261-38,661,783 (from NCBI)

This gene has 15 transcripts (splice variants), 160 orthologues, 28 paralogues and is associated with 120 phenotypes. Broad expression in fat (RPKM 7.8), spleen (RPKM 6.9) and 23 other tissues.

Summary

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and Apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate Cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

ERG Products(9)

mRNA	Protein	Name
NM_001136154.1	NP_001129626.1	transcriptional regulator ERG isoform 3
NM_001136155.1	NP_001129627.1	transcriptional regulator ERG isoform 4
NM_001243428.1	NP_001230357.1	transcriptional regulator ERG isoform 3
NM_001243429.1	NP_001230358.1	transcriptional regulator ERG isoform 5
NM_001243432.2	NP_001230361.1	transcriptional regulator ERG isoform 6
NM_001291391.1	NP_001278320.1	transcriptional regulator ERG isoform 7
NM_001331025.2	NP_001317954.1	transcriptional regulator ERG isoform 8
NM_004449.4	NP_004440.1	transcriptional regulator ERG isoform 2
NM_182918.4	NP_891548.1	transcriptional regulator ERG isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	18195090	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23093599	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20478527	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18195090	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18195090	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERG Protein Structure

SAM_PNT

Ets

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

transcriptional regulator ERG

ERG, ETS transcription factor

Recombinant ERG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71733	ERG Protein, Human (P.pastoris, His)	P11308-3 (M1-Y486)	≥95%

Related Diseases

Diseases

Alias

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Neurofibromatosis-Noonan Syndrome

NFNS	Neurofibromatosis Type 1
Neurofibromatosis With Noonan Phenotype	Nf1
Von Recklinghausen Disease	Neurofibromatosis Type 1-Noonan Syndrome
Noonan Neurofibromatosis Syndrome	Recklinghausen'S Disease
Noonan-Neurofibromatosis Syndrome	Fibromatosis Multiple Non Ossifying
Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots	Jaffe Campanacci Syndrome
Type 1 Neurofibromatosis	Neurofibromatosis 1
Peripheral Neurofibromatosis	Recklinghausen Disease, Nerve
Jaffe-Campanacci Syndrome

Neurofibromatosis, Type I

Von Recklinghausen Disease	Neurofibromatosis 1
Neurofibromatosis, Type 1	NF1
Neurofibromatosis, Peripheral Type	Neurofibromatosis Type I
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion	Familial Spinal Neurofibromatosis
Fsnf	Peripheral Neurofibromatosis
Von Recklinghausen'S Neurofibromatosis	Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion
Neurofibromatosis Peripheral Type	Von Recklinghausen Syndrome
Neurofibromatosis Type 1	Von Recklinghausen Neuropathy
Nf1 - [Neurofibromatosis Type 1]	Recklinghausen Disease

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W193545A	ERG240		≥98.0%	Unkown
HY-122234	VPC-18005	Inhibitor	99.32%	Unkown
HY-112158	NSC139021	Inhibitor	99.86%	Unkown
HY-16915	RPR-260243	Activator	99.91%	Unkown
HY-139893	ERGi-USU-6 mesylate	Inhibitor	≥95.0%	Unkown
HY-121964	cis-Piperidine-2,3-dicarboxylic acid	Agonist	≥98.0%	Unkown
HY-116445	UNC9975		/	Unkown
HY-144694	HDAC/HSP90-IN-3	Inhibitor	/	Unkown
HY-145814	HSP90-IN-9	Inhibitor	/	Unkown
HY-159585	CYP51-IN-20	Inhibitor	/	Unkown
HY-159730	ERG245	Inhibitor	/	Unkown
HY-N7848	Linoleamide		99.4%	Unkown
HY-RS04491	ERG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04492	ERG28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04493	ERGIC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04494	ERGIC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-117523	(Z)-RG-13022	Inhibitor	/	Unkown
HY-W749520	Zymosterone		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ERG	VGNC	VGNC:50174
Canis familiaris	ERG	VGNC	VGNC:40448
Felis catus	ERG	VGNC	VGNC:61937
Rattus norvegicus	ERG	RGD	RGD:621108
Mus musculus	ERG	MGD	MGI:95415
Macaca mulatta	ERG	VGNC	VGNC:72427
Canis lupus familiaris	ERG	NCBI
Others	ERG	NCBI

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