2. Gene
  3. ETS2 - ETS proto-oncogene 2, transcription factor Gene

ETS2 - ETS proto-oncogene 2, transcription factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ETS2IT1

Gene ID: 2114 | Gene type: protein coding

About ETS2

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:38,805,183-38,824,955 (from NCBI)

This gene has 9 transcripts (splice variants), 155 orthologues and 28 paralogues. Ubiquitous expression in spleen (RPKM 50.4), small intestine (RPKM 39.5) and 22 other tissues.

Summary

This gene encodes a transcription factor which regulates genes involved in development and Apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of Telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

ETS2 Products(2)

mRNA Protein Name
NM_001256295.2 NP_001243224.1 protein C-ets-2 isoform 2
NM_005239.6 NP_005230.1 protein C-ets-2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12637547 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12637547 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
IDA: Inferred from direct assay
11909962 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11909962 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18242510 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11583620 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12637547 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11909962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETS2 Protein Structure

SAM_PNT

SAM_PNT: Sterile alpha motif (SAM)/Pointed domain (88 - 169)

Ets

Ets: Ets-domain (363 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

protein C-ets-2

oncogene ETS-2

ETS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ETS2 P15036 COP1 Homo sapiens Q8NHY2
Anti Tag CoIP
25117710
Intra
ETS2 P15036 COP1 Homo sapiens Q8NHY2
Anti Tag CoIP
26496610
Intra
ETS2 P15036 CDK10 Homo sapiens Q15131
Anti Bait CoIP
18242510
Intra
ETS2 P15036 CDK10 Homo sapiens Q15131
Anti Tag CoIP
18242510
Intra
ETS2 P15036 TWIST1 Homo sapiens Q15672
Anti Bait CoIP
18598946
Intra
ETS2 P15036 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra
ETS2 P15036 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra
ETS2 P15036 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra
ETS2 P15036 SERPINH1 Homo sapiens P50454
Y2H Pooling
32814053
Intra
ETS2 P15036 SERPINH1 Homo sapiens P50454
Validated Y2H
32814053
Intra
ETS2 P15036 SERPINH1 Homo sapiens P50454
Y2H Array
32814053
Intra
ETS2 P15036 TP53 Homo sapiens P04637
Anti Bait CoIP
26331536
Intra
ETS2 P15036 TP53 Homo sapiens P04637
Pull Down
26331536
Intra
ETS2 P15036 TP53 Homo sapiens P04637
Anti Tag CoIP
26331536
Intra
ETS2 P15036 PRKACA Homo sapiens P17612
Validated Y2H
32814053
Intra
ETS2 P15036 PRKACA Homo sapiens P17612
Y2H Array
32814053
Intra
ETS2 P15036 PRKACA Homo sapiens P17612
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Choriocarcinoma

Chorioepithelioma
Acute Megakaryocytic Leukemia

Acute Megakaryoblastic Leukemia

Acute Megakaryoblastic Leukaemia

Megakaryocytic Myelosis

Thrombocytic Leukaemia

Amkl

Aml M7

Acute Myeloblastic Leukemia Type 7

Acute Myeloid Leukemia M7

Megakaryoblastic Leukemia Acute

Leukemia, Megakaryoblastic, Acute

Acute Myeloid Leukaemia, M7

Acute Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Fab M7

Fab M7

Malignant Megakaryocytosis

M7 - Acute Megakaryoblastic Leukaemia

Megakaryoblastic Leukaemia

Megakaryocytic Leukaemia

Acute Megakaryoblastic Leukaemia, Nos

Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
Endometrium Carcinoma In Situ

Carcinoma In Situ Of Endometrium

Endometrial Carcinoma In Situ
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Hyperhidrosis, Gustatory

Frey Syndrome

Gustatory Sweating

Auriculotemporal Nerve Syndrome

Gustatory Hyperhidrosis

Frey'S Syndrome

Sweating, Gustatory

HYPRG

Baillarger Syndrome

Hyperhidrosis Gustatory

Auriculotemporal Syndrome
Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis

Transient Myeloproliferative Syndrome

Transient Myeloproliferative Disease

Mst

Tam

Leukemia, Transient, Of Down Syndrome

Tmd

Leukemia, Transient

Transient Leukemia

Transient Leukemia Of Down Syndrome
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Chromosomal Duplication Syndrome
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Chromosomal Disease

Chromosomal Disorders

Congenital Chromosomal Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04563 ETS2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ETS2 MGD MGI:95456
Felis catus ETS2 VGNC VGNC:61981
Canis familiaris ETS2 VGNC VGNC:40495
Rattus norvegicus ETS2 RGD RGD:1584977
Macaca mulatta ETS2 VGNC VGNC:72440
Bos taurus ETS2 VGNC VGNC:28627