Cgas - cyclic GMP-AMP synthase Gene

Mus musculus

Also known as Mb21d1; E330016A19Rik

Gene ID: 214763 | Gene type: protein coding

About Cgas

Chromosome 9: 78,337,808-78,350,519 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 185 orthologues, 9 paralogues and is associated with 23 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 1.2), liver E18 (RPKM .8) and 27 other tissues.

Summary

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Cgas Products(1)

mRNA	Protein	Name
NM_173386.5	NP_775562.2	cyclic GMP-AMP synthase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2',3'-cyclic GMP-AMP synthase activity	IDA IDA: Inferred from direct assay	24077100	MGI
enables 2',3'-cyclic GMP-AMP synthase activity	IMP IMP: Inferred from mutant phenotype	23258413	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	26829768	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	28759028	MGI
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	24077100	MGI
enables nucleosome binding	IDA IDA: Inferred from direct assay	32911480	MGI
enables poly-ADP-D-ribose modification-dependent protein binding	IDA IDA: Inferred from direct assay	35210392	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26829768	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	29426904	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	23929945	MGI
involved in activation of innate immune response	IMP IMP: Inferred from mutant phenotype	23258413	MGI
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	24077100	MGI
involved in cAMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	23258413	MGI
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	24077100	MGI
involved in cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	23258413	MGI
involved in cellular response to exogenous dsRNA	IDA IDA: Inferred from direct assay	24077100	MGI
involved in cellular response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	23258413	MGI
involved in defense response to virus	IDA IDA: Inferred from direct assay	23929945	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	26371324	MGI
involved in negative regulation of DNA repair	IDA IDA: Inferred from direct assay	35210392	MGI
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	31544964	MGI
involved in negative regulation of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	30356214	MGI
involved in paracrine signaling	IDA IDA: Inferred from direct assay	24077100	MGI
involved in positive regulation of cellular senescence	IDA IDA: Inferred from direct assay	28759028	MGI
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	23929945	MGI
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	23258413	MGI
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	24077100	MGI
acts upstream of or within regulation of T cell activation	IGI IGI: Inferred from genetic interaction	26371324	MGI
acts upstream of or within regulation of immune response	IGI IGI: Inferred from genetic interaction	26371324	MGI
acts upstream of or within regulation of immunoglobulin production	IGI IGI: Inferred from genetic interaction	26371324	MGI
acts upstream of or within regulation of type I interferon production	IGI IGI: Inferred from genetic interaction	26371324	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	23258413	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	35210392	MGI
located in nucleus	IDA IDA: Inferred from direct assay	31544964	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	30827685	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cgas Protein Structure

PHA03247

Mab-21

0
100
200
300
400
507 a.a.

Protein Preferred Names

Protein Names

cyclic GMP-AMP synthase

2'3'-cGAMP synthase	Mab-21 domain containing 1
cGAMP synthase	mab-21 domain-containing protein 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-160406	SNX281	Agonist	99.08%	Phase 1

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114180	RU.521	Inhibitor	99.95%	Unkown
HY-131454	SR-717	Agonist	99.89%	Unkown
HY-133916	G140	Inhibitor	98.11%	Unkown
HY-128583	G150	Inhibitor	99.12%	Unkown
HY-150751	ODN TTAGGG	Antagonist	99.87%	Unkown
HY-114182	PF-06928215	Inhibitor	99.69%	Unkown
HY-139056	SU0268	Inhibitor	99.96%	Unkown
HY-W021040	Fludioxonil		99.94%	Unkown
HY-123230	Trifloxystrobin	Inhibitor	99.49%	Unkown
HY-114181	IRAK4-IN-4	Inhibitor	99.85%	Unkown
HY-150751C	ODN TTAGGG sodium	Antagonist	99.87%	Unkown
HY-149526	cGAS-IN-1	Inhibitor	98.29%	Unkown
HY-160546	cGAS-IN-2	Inhibitor	99.67%	Unkown
HY-B1331	Cyromazine		99.79%	Unkown
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium	Activator	/	Unkown
HY-158045	PROTAC PARP1 degrader-1	Inhibitor	99.86%	Unkown
HY-164288	TDI-6570	Inhibitor	99.64%	Unkown
HY-131454A	SR-717 free acid	Agonist	/	Unkown
HY-118578	Furalaxyl	Inhibitor	/	Unkown
HY-123230R	Trifloxystrobin (Standard)	Inhibitor	/	Unkown
HY-123230S	Trifloxystrobin-d6	Inhibitor	/	Unkown
HY-13735H	Quinacrine acetate		/	Unkown
HY-144328	STING agonist-10	Activator	/	Unkown
HY-144329	STING agonist-11	Activator	/	Unkown
HY-150751A	Biotin-labeled ODN TTAGGG sodium		/	Unkown
HY-150751B	FITC-labeled ODN TTAGGG sodium	Antagonist	/	Unkown
HY-158126	G-quadruplex ligand 2	Inhibitor	/	Unkown
HY-162133	MSA-2-Pt	Agonist	/	Unkown
HY-162459	cGAS-IN-3	Inhibitor	/	Unkown
HY-162944	NA-Ir		/	Unkown
HY-162966	MS7829	Degrader	/	Unkown
HY-162967	MS8588		/	Unkown
HY-163461	4F-DDC	Inhibitor	/	Unkown
HY-N12507	Eupenicisirenin C	Inhibitor	/	Unkown
HY-P3041	Chromostatin (bovine)	Inhibitor	/	Unkown
HY-RS02575	CGA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02576	CGAS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02577	Cgas Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02578	Cgas Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-114730	CGA-JK3	Inhibitor	/	Unkown
HY-12464	Butafenacil	Inhibitor	/	Unkown
HY-132221	CU-32	Inhibitor	/	Unkown
HY-79648S	Fmoc-Methylalanine-d3		/	Unkown
HY-W020788	Benoxacor	Agonist	99.39%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cgas	NCBI	NCBI:115004

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