FDPS - farnesyl diphosphate synthase Gene

Homo sapiens

Also known as FPS; FPPS; POROK9

Gene ID: 2224 | Gene type: protein coding

About FDPS

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,308,866-155,320,665 (from NCBI)

This gene has 21 transcripts (splice variants), 229 orthologues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 72.6), duodenum (RPKM 62.1) and 25 other tissues.

Summary

This gene encodes an Enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in Cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this Enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

FDPS Products(7)

mRNA	Protein	Name
NM_001135821.2	NP_001129293.1	farnesyl pyrophosphate synthase isoform a
NM_001135822.2	NP_001129294.1	farnesyl pyrophosphate synthase isoform b
NM_001242824.2	NP_001229753.1	farnesyl pyrophosphate synthase isoform b
NM_001242825.2	NP_001229754.1	farnesyl pyrophosphate synthase isoform c
NM_001378424.1	NP_001365353.1	farnesyl pyrophosphate synthase isoform b
NM_001378425.1	NP_001365354.1	farnesyl pyrophosphate synthase isoform b
NM_002004.4	NP_001995.1	farnesyl pyrophosphate synthase isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17198737	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	17198737	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	17198737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FDPS Protein Structure

polyprenyl_synt

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

farnesyl pyrophosphate synthase

(2E,6E)-farnesyl diphosphate synthase

FDPS Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FDPS	P14324	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	FDPS	P14324	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	FDPS	P14324	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	FDPS	P14324	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	FDPS	P14324	RNF19B	Homo sapiens	Q6ZMZ0	Validated Y2H	32296183
Intra	FDPS	P14324	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	FDPS	P14324	ABHD16A	Homo sapiens	O95870	Y2H Prey Pooling	32296183
Intra	FDPS	P14324	ABHD16A	Homo sapiens	O95870	Y2H Array	32296183
Intra	FDPS	P14324	SLC30A2	Homo sapiens	Q9BRI3	Validated Y2H	32296183
Intra	FDPS	P14324	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	FDPS	P14324	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	FDPS	P14324	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	FDPS	P14324	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FDPS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75197	FDPS Protein, Human (His)	P14324-2/NP_001129294.1 (M1-K353)	≥95%

Related Diseases

Diseases

Alias

Porokeratosis 9, Multiple Types

POROK9

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Punctate Porokeratosis

Porokeratosis, Punctate

Keratoderma, Palmoplantar, Punctate Type Ii

Osteonecrosis

Bone Necrosis	Avascular Necrosis Of Bone
Aseptic Necrosis	Necrosis Of Bone Nos
Aseptic Osteonecrosis	Aseptic Necrosis Of Bone, Site Unspecified
Aseptic Or Avascular Bone Necrosis	Aseptic Necrosis Of Bone
Necrotic Bone	Necrotizing Bone
Spontaneous Osteonecrosis	Osteoradionecrosis

Linear Porokeratosis

Congenital Facial Linear Porokeratosis

Porokeratosis, Linear

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Myasthenic Syndrome, Congenital, 2c, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 2c	CMS2C
Congenital Myasthenic Syndrome 2c Associated With Acetylcholine Receptor Deficiency	Myasthenic Syndrome, Congenital, Type 2c, Associated With Acetylcholine Receptor Deficiency

Mammary Paget'S Disease

Paget'S Disease	Mammary Paget Disease
Paget'S Disease Of The Breast	Paget Disease Of The Breast
Paget'S Disease Of The Nipple	Paget'S Disease, Mammary
Paget Cell Neoplasm	Paget Disease Of The Nipple
Pagets Disease Mammary	Osteitis Deformans

Ischemic Bone Disease

Bone Disease

Bone Diseases	Skeletal Disease
Skeletal Disorder	Disorder Of Skeletal System

Glucocorticoid-Induced Osteoporosis

Steroid-Induced Osteoporosis

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Paget'S Disease Of Bone

Osteitis Deformans	Paget Disease Of Bone
Osseous Paget'S Disease	Paget Disease Of Bone, Familial
Bone Paget Disease	Familial Paget'S Disease Of Bone
Paget'S Bone Disease	Familial Paget Disease Of Bone
Paget Disease, Bone	Pdb
Pagets Bone Disease

Bone Resorption Disease

Bone Resorption

Bone Remodeling Disease

Trypanosomiasis

Brittle Bone Disorder

Osteogenesis Imperfecta	Brittle Bone Disease
Fragilitas Ossium	Osteopsathyrosis
Lobstein Disease	Oi
Vrolik Disease	Lobstein'S Disease
Lobstein'S Syndrome	Vrolik'S Disease
Porak And Durante Disease	Glass Bone Disease
Osteogenesis Imperfecta, Dominant Perinatal Lethal	Osteogenesis Imperfecta, Recessive Perinatal Lethal
Brittle Bone Syndrome	Oi - [Osteogenesis Imperfecta]
Ossium Fragility	Osteitis Fragilitans
Bony Fragility	Blue Sclera With Fragility Of Bone And Deafness
White Blue Sclera - Fragility Of Bone - Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0631	Alendronic acid	Inhibitor	≥98.0%	Yes

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-106950A	Fosfructose trisodium		≥99.0%	Unkown
HY-148077	Phosphoglycolohydroxamic acid	Inhibitor	≥98.0%	Unkown
HY-B0631S	Alendronic acid-d6		≥98.0%	Unkown
HY-106950	Fosfructose		/	Unkown
HY-RS04853	FDPS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FDPS	RGD	RGD:68953
Mus musculus	FDPS	MGD	MGI:104888
Macaca mulatta	FDPS	VGNC	VGNC:106366
Canis familiaris	FDPS	VGNC	VGNC:40812
Others	FDPS	NCBI

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