2. Gene
  3. FOXM1 - forkhead box M1 Gene

FOXM1 - forkhead box M1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MPP2; HFH11; HNF-3; INS-1; MPP-2; PIG29; FKHL16; FOXM1A; FOXM1B; FOXM1C; HFH-11; TRIDENT; MPHOSPH2

Gene ID: 2305 | Gene type: protein coding

About FOXM1

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:2,857,680-2,877,174 (from NCBI)

This gene has 10 transcripts (splice variants), 211 orthologues and 42 paralogues. Broad expression in testis (RPKM 16.1), bone marrow (RPKM 11.2) and 16 other tissues.

Summary

The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

FOXM1 Products(24)

mRNA Protein Name
NM_001243088.2 NP_001230017.1 forkhead box protein M1 isoform 4
NM_001243089.2 NP_001230018.1 forkhead box protein M1 isoform 5
NM_001413925.1 NP_001400854.1 forkhead box protein M1 isoform 6
NM_001413926.1 NP_001400855.1 forkhead box protein M1 isoform 7
NM_001413927.1 NP_001400856.1 forkhead box protein M1 isoform 8
NM_001413928.1 NP_001400857.1 forkhead box protein M1 isoform 9
NM_001413929.1 NP_001400858.1 forkhead box protein M1 isoform 10
NM_001413930.1 NP_001400859.1 forkhead box protein M1 isoform 11
NM_001413931.1 NP_001400860.1 forkhead box protein M1 isoform 12
NM_001413932.1 NP_001400861.1 forkhead box protein M1 isoform 13
NM_001413933.1 NP_001400862.1 forkhead box protein M1 isoform 14
NM_001413934.1 NP_001400863.1 forkhead box protein M1 isoform 15
NM_001413935.1 NP_001400864.1 forkhead box protein M1 isoform 16
NM_001413936.1 NP_001400865.1 forkhead box protein M1 isoform 17
NM_001413937.1 NP_001400866.1 forkhead box protein M1 isoform 18
NM_001413938.1 NP_001400867.1 forkhead box protein M1 isoform 19
NM_001413939.1 NP_001400868.1 forkhead box protein M1 isoform 20
NM_001413940.1 NP_001400869.1 forkhead box protein M1 isoform 21
NM_001413941.1 NP_001400870.1 forkhead box protein M1 isoform 22
NM_001413942.1 NP_001400871.1 forkhead box protein M1 isoform 23
NM_001413943.1 NP_001400872.1 forkhead box protein M1 isoform 24
NM_021953.4 NP_068772.2 forkhead box protein M1 isoform 2
NM_202002.3 NP_973731.1 forkhead box protein M1 isoform 1
NM_202003.3 NP_973732.1 forkhead box protein M1 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
9032290 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
9032290 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21860419 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10523841 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19160488 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
IMP: Inferred from mutant phenotype
17101782 GOA
involved in G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
19160488 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20531406 GOA
involved in negative regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
19696738 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20531406 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9032290 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17101782 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19696738 GOA
involved in positive regulation of double-strand break repair IMP
IMP: Inferred from mutant phenotype
17101782 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19160488 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20531406 GOA
involved in regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
19696738 GOA
acts upstream of regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
19696738 GOA
involved in regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
19696738 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXM1 Protein Structure

Forkhead

Forkhead: Forkhead domain (236 - 319)

  • 0
  • 200
  • 400
  • 600
  • 763 a.a.
Protein Preferred Names Protein Names

forkhead box protein M1

Forkhead, drosophila, homolog-like 16

Recombinant FOXM1 Proteins

Cat. No. Product Name Accession Purity
HY-P72197 FOXM1 Protein, Human (His, SUMO-Myc) Q08050-1 (E235-L327) ≥95%

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency

Proc Deficiency

Congenital Thrombotic Disease, Due To Protein C Deficiency
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Anaplastic Astrocytoma

Grade Iii Astrocytoma

Astrocytoma, Anaplastic

Grade Iii Astrocytic Tumor
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Uterine Adnexa Cancer
Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma
Pancreatic Cystadenoma

Cystadenoma Of Pancreas
Joubert Syndrome 8

JBTS8

Joubert Syndrome, Type 8
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Sarcomatoid Transitional Cell Carcinoma

Transitional Cell Carcinoma, Sarcomatoid

Transitional Spindle Cell Carcinoma

Transitional Cell Carcinoma, Spindle Cell
Diabetes Mellitus

Diabetes
Rhabdomyosarcoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8

Iddm8

Insulin-Dependent Diabetes Mellitus 8

T1D8

Insulin-Dependent Diabetes Mellitus-8
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0990 Thiostrepton Inhibitor 99.80% Unkown
HY-112721 FDI-6 Inhibitor 99.65% Unkown
HY-19979 RCM-1 Inhibitor 99.58% Unkown
HY-148530 YX-2-107 Degrader 99.79% Unkown
HY-117522 Sepin-1 Inhibitor 97.89% Unkown
HY-151986 FOXM1-IN-1 Inhibitor 99.54% Unkown
HY-158420 STL001 Inducer / Unkown
HY-P1687 Siomycin A / Unkown
HY-112509 STL427944 Inhibitor / Unkown
HY-156609 FOXM1-IN-2 Inhibitor / Unkown
HY-161617 LASSBio-2052 Inhibitor / Unkown
HY-P10553 ARF(26–44), cell-permeable / Unkown
HY-RS05064 FOXM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FOXM1 RGD RGD:61807
Canis familiaris FOXM1 VGNC VGNC:40959
Mus musculus FOXM1 MGD MGI:1347487
Felis catus FOXM1 VGNC VGNC:62339
Bos taurus FOXM1 VGNC VGNC:29094
Macaca mulatta FOXM1 VGNC VGNC:72702
Others FOXM1 NCBI