2. Gene
  3. PSMD3 - proteasome 26S subunit, non-ATPase 3 Gene

PSMD3 - proteasome 26S subunit, non-ATPase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as S3; P58; RPN3; TSTA2

Gene ID: 5709 | Gene type: protein coding

About PSMD3

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:39,980,807-39,997,959 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 31.7), brain (RPKM 31.3) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the Proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]

PSMD3 Products(1)

mRNA Protein Name
NM_002809.4 NP_002800.2 26S proteasome non-ATPase regulatory subunit 3
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15147878 GOA
Cellular Component GO Annotation Evidence Reference Source
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD3 Protein Structure

PCI

PCI: PCI domain (359 - 461)

Rpn3_C

Rpn3_C: Proteasome regulatory subunit C-terminal (465 - 531)

  • 0
  • 100
  • 200
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  • 500
  • 534 a.a.
Protein Preferred Names Protein Names

26S proteasome non-ATPase regulatory subunit 3

26S proteasome regulatory subunit RPN3

PSMD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PSMD3 O43242 NFKBIA Homo sapiens P25963
Y2H Prey Pooling
32296183
Intra PSMD3 O43242 NFKBIA Homo sapiens P25963
Validated Y2H
32296183
Intra PSMD3 O43242 NFKBIA Homo sapiens P25963
Y2H Array
32296183
Intra PSMD3 O43242 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
35271311
Intra PSMD3 O43242 PSMA6 Homo sapiens P60900
Validated Y2H
32296183
Intra PSMD3 O43242 PSMD4 Homo sapiens P55036
Anti Tag CoIP
35271311
Intra PSMD3 O43242 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra PSMD3 O43242 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra PSMD3 O43242 HTT Homo sapiens P42858
Y2H Array
32814053
Intra PSMD3 O43242 ZBTB43 Homo sapiens O43298
Y2H Array
31515488
Intra PSMD3 O43242 ZBTB43 Homo sapiens O43298
Validated Y2H
32296183
Intra PSMD3 O43242 ZBTB43 Homo sapiens O43298
Y2H Prey Pooling
32296183
Intra PSMD3 O43242 ZBTB43 Homo sapiens O43298
Y2H Prey Pooling
25416956
Intra PSMD3 O43242 ZBTB43 Homo sapiens O43298
Y2H Array
32296183
Intra PSMD3 O43242 CEP44 Homo sapiens Q9C0F1
Validated Y2H
25416956
Intra PSMD3 O43242 CEP44 Homo sapiens Q9C0F1
Y2H Array
25416956
Intra PSMD3 O43242 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra PSMD3 O43242 SEM1 Homo sapiens P60896
Y2H Prey Pooling
25416956
Intra PSMD3 O43242 SEM1 Homo sapiens P60896
Validated Y2H
25416956
Intra PSMD3 O43242 SEM1 Homo sapiens P60896
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypothyroidism, Congenital, Nongoitrous, 2

Thyroid Dysgenesis

CHNG2

Thyroid Hypoplasia

Thyroid Hemiagenesis

Thyroid Agenesis

Athyreotic Hypothyroidism

Rtsh

Thyrotropin Resistance

Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Or Hypoplasia

Congenital Nongoitrous Hypothyroidism 2

Thyroid, Ectopic

Hypothyroidism, Congenital, Due To Thyroid Dysgenesis

Hypothyroidism, Athyreotic

Thyrotropin

Resistance To Thyrotropin

Congenital Hypothyroidism Due To Thyroid Dysgenesis Or Hypoplasia

Hypothyroidism, Congenital, Non-Goitrous, 2

Congenital Hypothyroidism Due To Thyroid Dysgenesis

Thyroid-Stimulating Hormone Resistance

Thyroid Ectopic

Ectopic Thyroid

Hypothyroidism, Congenital, Nongoitrous, 3

Thyroid Hormone Resistance Syndrome

Hypothyroidism, Congenital, Nongoitrous, 1
Glioblastoma Proneural Subtype
Inflammatory Bowel Disease 22

IBD22
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11324 PSMD3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PSMD3 RGD RGD:1311470
Macaca mulatta PSMD3 VGNC VGNC:76452
Mus musculus PSMD3 MGD MGI:98858
Felis catus PSMD3 VGNC VGNC:69124
Bos taurus PSMD3 VGNC VGNC:33467
Canis familiaris PSMD3 VGNC VGNC:45112