FOSL2 - FOS like 2, AP-1 transcription factor subunit Gene

Homo sapiens

Also known as FRA2

Gene ID: 2355 | Gene type: protein coding

About FOSL2

Cytogenetic location: 2p23.2 Genomic coordinates (GRCh38): 2:28,392,858-28,417,317 (from NCBI)

This gene has 4 transcripts (splice variants), 225 orthologues and 8 paralogues. Ubiquitous expression in adrenal (RPKM 58.8), bone marrow (RPKM 50.0) and 23 other tissues.

Summary

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

FOSL2 Products(1)

mRNA	Protein	Name
NM_005253.4	NP_005244.1	fos-related antigen 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	13679379	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	13679379	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19321746	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	13679379	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOSL2 Protein Structure

bZIP_1

0
100
200
300
326 a.a.

Protein Preferred Names

Protein Names

fos-related antigen 2

FOS like 2, AP-1 trancription factor subunit

FOSL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOSL2	P15408	FLJ13057	Homo sapiens	Q53SE7	Y2H Array	25416956
Intra	FOSL2	P15408	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	FOSL2	P15408	DDIT3	Homo sapiens	P35638-2	Validated Y2H	25416956
Intra	FOSL2	P15408	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32296183
Intra	FOSL2	P15408	CREB5	Homo sapiens	Q02930-3	Validated Y2H	25416956
Intra	FOSL2	P15408	CREB5	Homo sapiens	Q02930-3	Y2H Array	32296183
Intra	FOSL2	P15408	CREB5	Homo sapiens	Q02930-3	Y2H Prey Pooling	25416956
Intra	FOSL2	P15408	CREB5	Homo sapiens	Q02930-3	Y2H Array	25416956
Intra	FOSL2	P15408	CREB5	Homo sapiens	Q02930-3	Y2H Prey Pooling	32296183
Intra	FOSL2	P15408	CREB5	Homo sapiens	Q02930-3	Validated Y2H	27107012
Intra	FOSL2	P15408	CREB5	Homo sapiens	Q02930-3	BFG-2H	27107012
Intra	FOSL2	P15408	LUZP4	Homo sapiens	Q9P127	Y2H Prey Pooling	25416956
Intra	FOSL2	P15408	ATF2	Homo sapiens	P15336	Anti Tag CoIP	33961781
Intra	FOSL2	P15408	ATF2	Homo sapiens	P15336	Anti Tag CoIP	28514442
Intra	FOSL2	P15408	ATF2	Homo sapiens	P15336	Peptide Array	20102225
Intra	FOSL2	P15408	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	FOSL2	P15408	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
Intra	FOSL2	P15408	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	28514442
Intra	FOSL2	P15408	BACH2	Homo sapiens	Q9BYV9	Validated Y2H	32296183
Intra	FOSL2	P15408	BACH2	Homo sapiens	Q9BYV9	Anti Tag CoIP	33961781
Intra	FOSL2	P15408	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	FOSL2	P15408	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	FOSL2	P15408	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	FOSL2	P15408	JUND	Homo sapiens	P17535	Anti Tag CoIP	33961781
Intra	FOSL2	P15408	JUND	Homo sapiens	P17535	Anti Tag CoIP	26496610
Intra	FOSL2	P15408	JUND	Homo sapiens	P17535	Anti Tag CoIP	28514442
Intra	FOSL2	P15408	JUND	Homo sapiens	P17535	Peptide Array	20102225
Intra	FOSL2	P15408	POLR2G	Homo sapiens	P62487	Y2H Prey Pooling	32296183
Intra	FOSL2	P15408	POLR2G	Homo sapiens	P62487	Validated Y2H	32296183
Intra	FOSL2	P15408	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
Intra	FOSL2	P15408	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	FOSL2	P15408	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	FOSL2	P15408	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	FOSL2	P15408	GOPC	Homo sapiens	Q9HD26	Y2H Array	31515488
Intra	FOSL2	P15408	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	FOSL2	P15408	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	FOSL2	P15408	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	FOSL2	P15408	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	FOSL2	P15408	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	FOSL2	P15408	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	FOSL2	P15408	TRAF1	Homo sapiens	Q13077	BFG-2H	27107012
Intra	FOSL2	P15408	TRAF1	Homo sapiens	Q13077	Validated Y2H	27107012
Intra	FOSL2	P15408	DNAJA3	Homo sapiens	Q96EY1-2	Y2H Prey Pooling	25416956
Intra	FOSL2	P15408	DNAJA3	Homo sapiens	Q96EY1-2	Validated Y2H	25416956
Intra	FOSL2	P15408	LRIF1	Homo sapiens	Q5T3J3	Validated Y2H	32296183
Intra	FOSL2	P15408	LRIF1	Homo sapiens	Q5T3J3	Y2H Array	32296183
Intra	FOSL2	P15408	LRIF1	Homo sapiens	Q5T3J3	Y2H Prey Pooling	32296183
Intra	FOSL2	P15408	FHL3	Homo sapiens	Q13643	Y2H Array	31515488
Intra	FOSL2	P15408	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	25416956
Intra	FOSL2	P15408	UBQLN1	Homo sapiens	Q9UMX0	Y2H Pooling	32814053
Intra	FOSL2	P15408	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32814053
Intra	FOSL2	P15408	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32814053
Intra	FOSL2	P15408	DDIT3	Homo sapiens	P35638	Y2H Prey Pooling	32296183
Intra	FOSL2	P15408	DDIT3	Homo sapiens	P35638	Y2H Array	32296183
Intra	FOSL2	P15408	DDIT3	Homo sapiens	P35638	BFG-2H	27107012
Intra	FOSL2	P15408	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	FOSL2	P15408	DDIT3	Homo sapiens	P35638	Validated Y2H	32296183
Intra	FOSL2	P15408	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	FOSL2	P15408	JUNB	Homo sapiens	P17275	Anti Tag CoIP	26496610
Intra	FOSL2	P15408	JUNB	Homo sapiens	P17275	Anti Tag CoIP	33961781
Intra	FOSL2	P15408	JUNB	Homo sapiens	P17275	Peptide Array	20102225
Intra	FOSL2	P15408	JUNB	Homo sapiens	P17275	Anti Bait CoIP	19321746
Intra	FOSL2	P15408	JUNB	Homo sapiens	P17275	Validated Y2H	32296183
Intra	FOSL2	P15408	ATF7	Homo sapiens	P17544	Peptide Array	20102225
Intra	FOSL2	P15408	ATF7	Homo sapiens	P17544	Anti Tag CoIP	33961781
Intra	FOSL2	P15408	LHX8	Homo sapiens	Q68G74	Y2H Prey Pooling	32296183
Intra	FOSL2	P15408	LHX8	Homo sapiens	Q68G74	Y2H Array	32296183
Intra	FOSL2	P15408	LHX8	Homo sapiens	Q68G74	Validated Y2H	32296183
Intra	FOSL2	P15408	JUN	Homo sapiens	P05412	Anti Tag CoIP	26496610
Intra	FOSL2	P15408	JUN	Homo sapiens	P05412	Peptide Array	20102225
Intra	FOSL2	P15408	JUN	Homo sapiens	P05412	Anti Tag CoIP	33961781
Intra	FOSL2	P15408	JUN	Homo sapiens	P05412	Y2H Array	32296183
Intra	FOSL2	P15408	JUN	Homo sapiens	P05412	Anti Tag CoIP	28514442
Intra	FOSL2	P15408	JUN	Homo sapiens	P05412	Y2H Prey Pooling	32296183
Intra	FOSL2	P15408	CYTH1	Homo sapiens	Q15438	Y2H Prey Pooling	32296183
Intra	FOSL2	P15408	CYTH1	Homo sapiens	Q15438	Validated Y2H	32296183
Intra	FOSL2	P15408	CYTH1	Homo sapiens	Q15438	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

FOSL2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82973	FRA2 Antibody (YA2718)	WB, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05035	FOSL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FOSL2	MGD	MGI:102858
Bos taurus	FOSL2	VGNC	VGNC:29076
Rattus norvegicus	FOSL2	RGD	RGD:2628
Canis familiaris	FOSL2	VGNC	VGNC:40943
Macaca mulatta	FOSL2	VGNC	VGNC:72691
Felis catus	FOSL2	VGNC	VGNC:80101

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